Genetically modified extracellular vesicles loaded with activated gasdermin D potentially inhibit prostate-specific membrane antigen-positive prostate carcinoma growth and enhance immunotherapy DOI Creative Commons
Ke Gao,

Wenjin Xi,

Jianxin Ni

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: unknown, P. 122894 - 122894

Published: Oct. 1, 2024

Language: Английский

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment DOI Creative Commons

Haihong Lin,

Jun Zhou, Tao Ding

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: June 28, 2024

Abstract Cancer, a prevalent and complex disease, presents significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion of nearby tissues, spread distant organs. Its progression involves interplay several elements processes. Extracellular vesicles (EVs) serve as critical intermediaries in intercellular communication, transporting molecules such lipids, RNA, membrane, cytoplasmic proteins between cells. They significantly contribute progression, development, dissemination primary tumors facilitating exchange information transmitting signals that regulate tumor growth metastasis. However, EVs do not have singular impact on cancer; instead, they play multifaceted dual role. Under specific circumstances, can impede influence cancer delivering oncogenic factors or triggering an immune response. Furthermore, from different sources demonstrate distinct advantages inhibiting cancer. This research examines biological characteristics their involvement development establish theoretical foundation for better understanding connection Here, we discuss potential various therapy, well current status future prospects engineered developing more effective treatments.

Language: Английский

Citations

7
Direct profiling of breast cancer-derived extracellular vesicles using Pd-perovskite electrochemical biosensing platform DOI Creative Commons
Ehsan Dezhakam, Balal Khalilzadeh, Abdolhossein Naseri

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 13, 2024

Abstract Extracellular vesicles (EVs) harbor several signaling molecules to maintain intercellular communication. Based on the exosomal cargo type, metabolic, genomic, and proteomic status of parent cells can be investigated. Due existence trivial levels target inside EVs, application accurate sensitive detection methods is mandatory. Here, we used an electrochemical immunosensor using a biotinylated monoclonal CD63 antibody as capturing element for EVs isolated from MDA-MB-231 cancer patients. Simultaneously, breast biomarker CA-15-3 was detected in sandwich method increase specificity. Data indicated linear dynamic range 2000–10000 EVs/µL lower limit quantification 2000 EVs/µL. data real sample analysis, differ according severity systemic content this factor. Pd-perovskite-based provides platform quick in-depth analysis cells.

Language: Английский

Citations

4
Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer DOI
Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu, Muhammad Afzal

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

0
Fucoxanthin Attenuates Angiogenesis by Blocking the VEGFR2-Mediated Signaling Pathway through Binding the Vascular Endothelial Growth Factor DOI

Guo-Xia Guo,

Yu-Huan Qiu,

Yang Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Fucoxanthin, a dietary carotenoid, is predominantly found in edible brown algae and commonly consumed worldwide. Fucoxanthin has been shown to possess beneficial health activities such as antidiabetic, anti-inflammatory, antimutagenic, antiobesity; however, the effects of fucoxanthin on VEGF-mediated angiogenesis its possible binding with VEGF are unknown. Here, different lines evidence supported suppressive roles angiogenesis. In human umbilical vein endothelial cells, remarkedly suppressed cell proliferative, migration, invasive abilities, well tube formation, without cytotoxicity. addition, inhibited subintestinal vessel formation zebrafish

Language: Английский

Citations

1
Exosomes and breast cancer angiogenesis; Highlights in intercellular communication DOI Creative Commons

Parisa Khanicheragh,

Zahra Abbasi‐Malati,

Solmaz Saghebasl

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Breast cancer (BC) is a prevalent and highly lethal in females. Like other types, the intricate cellular molecular heterogeneity leads to variation of therapeutic outcomes. The development progression blood vessels increase tumor cell expansion metastasis remote sites. Based on several pieces scientific data, different mediators cells are involved promotion angiogenesis into parenchyma. Recent data have indicated critical role extracellular vesicles, especially exosomes (Exos), transfer molecules between BC cells. Due unique physicochemical properties, certain signaling molecules, Exos at center attention terms biomarkers bullets patients. Along with these statements, understanding modulatory seems clinical setting. Here, mechanisms by which can orchestrate phenomenon via discussed detail. present study help us understand pro-/anti-angiogenesis design better oncostatic strategies.

Language: Английский

Citations

1
Antibacterial composite protein microneedle loaded with hypoxia-treated exosomes for oral ulcer healing DOI
Yiyu Zeng, Xiaoyan Xie, Yijun Gao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105952 - 105952

Published: July 9, 2024

Language: Английский

Citations

0
The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome DOI

Naoufal Akla,

C Veilleux,

Borhane Annabi

et al.

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Sept. 19, 2024

Cancer cells-derived extracellular vesicles can trigger the transformation of adipose-derived mesenchymal stem cells (ADMSC) into a pro-inflammatory, cancer-associated adipocyte (CAA) phenotype. Such secretome-mediated crosstalk between adipose tissue and tumor microenvironment (TME) therefore impacts progression metastatic processes. In addition, emerging roles diet-derived phytochemicals, especially epigallocatechin-3-gallate (EGCG) among other polyphenols, in modulating exosome-mediated metabolic inflammatory signaling pathways have been highlighted. Here, we discuss how selected phytochemicals could alter secretome signature as well dynamics TME, with focus on breast cancer. Their broader implication chemoprevention obesity-related cancers is also discussed.

Language: Английский

Citations

0
Genetically modified extracellular vesicles loaded with activated gasdermin D potentially inhibit prostate-specific membrane antigen-positive prostate carcinoma growth and enhance immunotherapy DOI Creative Commons
Ke Gao,

Wenjin Xi,

Jianxin Ni

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: unknown, P. 122894 - 122894

Published: Oct. 1, 2024

Language: Английский

Citations

0