Cell Biology International,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 30, 2025
ABSTRACT
Pediatric
respiratory
diseases,
ranging
from
acute
infections
to
chronic
lung
conditions,
pose
significant
morbidity
and
mortality
risks.
Current
treatment
approaches
focus
on
symptomatic
relief
rather
than
regenerative
solutions.
Stem
cell
therapy
has
emerged
as
a
promising
alternative
due
its
potential
for
immunomodulation,
inflammation
reduction,
tissue
repair.
Mesenchymal
stem
cells
(MSCs)
induced
pluripotent
(iPSCs)
have
been
extensively
studied
their
properties,
with
MSC‐derived
extracellular
vesicles
showing
cell‐free
therapeutic
approach.
Despite
preclinical
early
clinical
findings,
challenges
such
immune
rejection,
ethical
concerns,
the
need
standardized
protocols
hinder
translation.
This
review
examines
recent
advancements
in
pediatric
outlining
potential,
limitations,
future
research
directions.
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Янв. 4, 2025
Colorectal
cancer
(CRC)
continues
to
be
a
major
worldwide
health
issue,
with
elevated
death
rates
linked
late
stages
of
the
illness.
Immunotherapy
has
made
significant
progress
in
developing
effective
techniques
improve
immune
system's
capacity
identify
and
eradicate
cancerous
cells.
This
study
examines
most
recent
advancements
CAR-T
cell
treatment
exosome-based
immunotherapy
for
CRC.
therapy,
although
treating
blood
cancers,
encounters
obstacles
when
used
against
solid
tumors
such
as
These
include
presence
an
immunosuppressive
tumor
microenvironment
scarcity
tumor-specific
antigens.
Nevertheless,
novel
strategies
like
dual-receptor
cells
combination
therapy
involving
cytokines
have
demonstrated
promise
surmounting
these
obstacles.
Exosome-based
is
promising
approach
targeted
delivery
therapeutic
drugs
cells,
high
specificity
minimal
off-target
effects.
However,
there
are
still
overcome
field,
resistance
treatment,
adverse
effects
associated
system,
necessity
more
individualized
methods.
The
current
research
focused
on
enhancing
therapies,
results
patients,
ultimately
incorporating
innovative
immunotherapeutic
approaches
into
standard
protocols
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 10, 2025
Esophageal
cancer
(EC)
is
among
the
most
common
illnesses
globally,
and
its
prognosis
unfavorable.
Surgery,
radiotherapy,
chemotherapy
are
primary
therapy
options
for
EC.
Despite
occasional
efficacy
of
these
traditional
treatment
modalities,
individuals
with
EC
remain
at
a
significant
risk
local
recurrence
metastasis.
Consequently,
innovative
efficacious
medicines
required.
In
recent
decades,
clinical
practice
has
effectively
implemented
cell
therapy,
which
includes
both
stem
non-stem
cell-based
approaches,
as
an
tumor
treatment,
offering
renewed
hope
to
patients
esophageal
squamous
carcinoma
(ESCC).
This
paper
examines
theoretical
framework
contemporary
advancements
in
We
further
described
current
studies
summarized
essential
data
related
survival
safety
assessments.
Abstract
Exosomes,
small
extracellular
vesicles
with
lipid
bilayer
membranes,
play
a
crucial
role
in
cellular
communication
and
can
transfer
diverse
biological
cargo,
including
proteins,
lipids,
nucleic
acids,
from
donor
to
recipient
cells.
Exosomes
possess
immunological
properties,
such
as
antigen
delivery
immune
activation,
along
excellent
drug
capabilities,
making
them
promising
candidates
for
vaccine
development.
For
different
diseases,
exosome‐based
vaccines
be
designed
therapeutic
or
prophylactic
by
leveraging
immunity
humoral
immunity.
With
the
emergence
of
precision
medicine,
personalized
demonstrate
exceptional
potential.
This
review
systematically
introduces
sources,
biogenesis
mechanisms,
components
exosomes
describes
their
regulatory
roles
system.
Subsequently,
preparation,
administration,
therapy
are
discussed.
Finally,
applications
clinical
trials
fields
anti‐infection
anti‐tumor
therapies
particularly
highlighted,
an
analysis
potential
challenges
future
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2025,
Номер
44(1)
Опубликована: Май 2, 2025
Abstract
Extracellular
vesicles
(EVs),
particularly
engineered
variants,
have
emerged
as
promising
tools
in
cancer
immunotherapy
due
to
their
inherent
ability
modulate
immune
responses
and
deliver
therapeutic
agents
with
high
specificity
minimal
toxicity.
These
nanometer-sized
vesicles,
which
include
exosomes
(Exos)
other
subtypes,
naturally
participate
intercellular
communication
are
capable
of
carrying
a
diverse
range
bioactive
molecules,
including
proteins,
lipids,
RNAs,
metabolites.
Recent
advancements
the
biogenesis
EVs,
such
strategies
modify
surface
characteristics
cargo,
significantly
expanded
potential
effective
vehicles
for
targeted
therapies.
Tailoring
contents
incorporating
immunomodulatory
molecules
or
gene-editing
(GETs),
has
shown
outcomes
enhancing
anti-tumor
immunity
overcoming
immunosuppressive
tumor
microenvironment
(TME).
Moreover,
optimizing
delivery
mechanisms,
through
both
passive
active
targeting
strategies,
is
crucial
improving
clinical
efficacy
EV-based
This
review
provides
an
overview
recent
developments
engineering
EVs
immunotherapy,
focusing
on
biogenesis,
methods
content
customization,
innovations
cargo
delivery.
Additionally,
addresses
challenges
associated
translation
therapies,
issues
related
scalability,
safety,
By
offering
insights
into
current
state
field
identifying
key
areas
future
research,
this
aims
advance
application
treatment.
Journal of the Egyptian National Cancer Institute,
Год журнала:
2025,
Номер
37(1)
Опубликована: Май 1, 2025
Extracellular
vesicles
(EVs)
have
emerged
as
key
cell-to-cell
communication
mediators
and
play
significant
roles
in
both
physiological
pathological
processes.
In
EVs,
exosomes
represent
a
distinct
subpopulation
of
EVs
that
been
found
to
be
involved
cancer
initiation
therapeutic
resistance.
Exosomes
transfer
diverse
spectrum
molecular
cargos
effects
on
the
tumor
microenvironment
(TME),
thereby
enabling
initiation,
metastasis,
recently
interest
therapy
due
their
role
important
treatment
The
exosomal
content-proteins,
miRNAs,
lncRNAs-allows
perform
functions
including
drug
efflux
detoxification,
cell
death
pathway
modulation,
induction
epithelial-to-mesenchymal
transition
(EMT),
suppression
immune
system.
addition
facilitating
stromal
interactions,
cause
extracellular
matrix
remodeling
induce
heterogeneity,
making
it
more
difficult
respond
therapy.
This
review
covers
intricate
resistance
with
regard
biogenesis,
content,
functional
impact
TME.
Along
this,
we
also
discuss
new
strategies
overcome
exosome-mediated
utilizing
exosome
inhibitors,
designed
therapy,
combination
conventional
therapies.
While
hold
promise
prediction
diagnosis
through
biomarker
function,
heterogeneous
origins
cryptic
make
target
interventions.
emphasizes
research
pathways
is
urgently
required
develop
can
improve
outcomes.
Advanced technology in neuroscience .,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Currently,
treatments
such
as
stem
cell
transplantation,
gene
therapy,
and
anti-inflammatory
approaches
have
shown
some
promise
in
addressing
spinal
cord
injury.
However,
there
is
still
a
lack
of
more
effective
treatment
options.
Thus,
improved
strategies
are
needed
to
enhance
efficacy
promote
functional
recovery.
Exosome-based
therapy
has
emerged
promising
strategy
because
exosomes
can
deliver
bioactive
molecules,
modulate
inflammation,
tissue
regeneration.
This
review
highlights
recent
advancements
the
use
derived
from
various
types,
including
mesenchymal
cells
macrophages,
for
Exosomes
nanoscale
vesicles
secreted
by
that
involved
transporting
biomolecules,
regulating
intercellular
communication,
reducing
inflammatory
responses,
promoting
angiogenesis,
providing
neuroprotection.
The
article
discusses
diagnostic,
therapeutic,
prognostic
roles
exosomes,
along
with
administration
methods.
It
mechanisms
which
different
types
facilitate
injury
repair,
nerve
regeneration,
inhibiting
apoptosis,
an
antioxidant
stress
response.
Additionally,
emerging
techniques
engineered
targeted
delivery
systems
explored
therapeutic
specificity.
Although
exosome
faces
challenges,
need
standardized
preparation,
precise
delivery,
dose
optimization,
bioengineered
show
potential.
Overall,
exosome-based
technology
neuroscience
offers
new
perspectives
methods
treating
injury,
potential
improve
recovery
patients,
thereby
warranting
future
clinical
translation.
