Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)
Published: May 15, 2025
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 13, 2025
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.
Language: Английский
Citations
22
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23
Published: Jan. 4, 2025
Colorectal cancer (CRC) continues to be a major worldwide health issue, with elevated death rates linked late stages of the illness. Immunotherapy has made significant progress in developing effective techniques improve immune system's capacity identify and eradicate cancerous cells. This study examines most recent advancements CAR-T cell treatment exosome-based immunotherapy for CRC. therapy, although treating blood cancers, encounters obstacles when used against solid tumors such as These include presence an immunosuppressive tumor microenvironment scarcity tumor-specific antigens. Nevertheless, novel strategies like dual-receptor cells combination therapy involving cytokines have demonstrated promise surmounting these obstacles. Exosome-based is promising approach targeted delivery therapeutic drugs cells, high specificity minimal off-target effects. However, there are still overcome field, resistance treatment, adverse effects associated system, necessity more individualized methods. The current research focused on enhancing therapies, results patients, ultimately incorporating innovative immunotherapeutic approaches into standard protocols
Language: Английский
Citations
1
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19
Published: March 10, 2025
Esophageal cancer (EC) is among the most common illnesses globally, and its prognosis unfavorable. Surgery, radiotherapy, chemotherapy are primary therapy options for EC. Despite occasional efficacy of these traditional treatment modalities, individuals with EC remain at a significant risk local recurrence metastasis. Consequently, innovative efficacious medicines required. In recent decades, clinical practice has effectively implemented cell therapy, which includes both stem non-stem cell-based approaches, as an tumor treatment, offering renewed hope to patients esophageal squamous carcinoma (ESCC). This paper examines theoretical framework contemporary advancements in We further described current studies summarized essential data related survival safety assessments.
Language: Английский
Citations
1
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 52(1)
Published: Dec. 26, 2024
Language: Английский
Citations
4
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract Exosomes, small extracellular vesicles with lipid bilayer membranes, play a crucial role in cellular communication and can transfer diverse biological cargo, including proteins, lipids, nucleic acids, from donor to recipient cells. Exosomes possess immunological properties, such as antigen delivery immune activation, along excellent drug capabilities, making them promising candidates for vaccine development. For different diseases, exosome‐based vaccines be designed therapeutic or prophylactic by leveraging immunity humoral immunity. With the emergence of precision medicine, personalized demonstrate exceptional potential. This review systematically introduces sources, biogenesis mechanisms, components exosomes describes their regulatory roles system. Subsequently, preparation, administration, therapy are discussed. Finally, applications clinical trials fields anti‐infection anti‐tumor therapies particularly highlighted, an analysis potential challenges future
Language: Английский
Citations
0
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: April 19, 2025
Language: Английский
Citations
0
Journal of the Egyptian National Cancer Institute, Journal Year: 2025, Volume and Issue: 37(1)
Published: May 1, 2025
Extracellular vesicles (EVs) have emerged as key cell-to-cell communication mediators and play significant roles in both physiological pathological processes. In EVs, exosomes represent a distinct subpopulation of EVs that been found to be involved cancer initiation therapeutic resistance. Exosomes transfer diverse spectrum molecular cargos effects on the tumor microenvironment (TME), thereby enabling initiation, metastasis, recently interest therapy due their role important treatment The exosomal content-proteins, miRNAs, lncRNAs-allows perform functions including drug efflux detoxification, cell death pathway modulation, induction epithelial-to-mesenchymal transition (EMT), suppression immune system. addition facilitating stromal interactions, cause extracellular matrix remodeling induce heterogeneity, making it more difficult respond therapy. This review covers intricate resistance with regard biogenesis, content, functional impact TME. Along this, we also discuss new strategies overcome exosome-mediated utilizing exosome inhibitors, designed therapy, combination conventional therapies. While hold promise prediction diagnosis through biomarker function, heterogeneous origins cryptic make target interventions. emphasizes research pathways is urgently required develop can improve outcomes.
Language: Английский
Citations
0
Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)
Published: May 2, 2025
Abstract Extracellular vesicles (EVs), particularly engineered variants, have emerged as promising tools in cancer immunotherapy due to their inherent ability modulate immune responses and deliver therapeutic agents with high specificity minimal toxicity. These nanometer-sized vesicles, which include exosomes (Exos) other subtypes, naturally participate intercellular communication are capable of carrying a diverse range bioactive molecules, including proteins, lipids, RNAs, metabolites. Recent advancements the biogenesis EVs, such strategies modify surface characteristics cargo, significantly expanded potential effective vehicles for targeted therapies. Tailoring contents incorporating immunomodulatory molecules or gene-editing (GETs), has shown outcomes enhancing anti-tumor immunity overcoming immunosuppressive tumor microenvironment (TME). Moreover, optimizing delivery mechanisms, through both passive active targeting strategies, is crucial improving clinical efficacy EV-based This review provides an overview recent developments engineering EVs immunotherapy, focusing on biogenesis, methods content customization, innovations cargo delivery. Additionally, addresses challenges associated translation therapies, issues related scalability, safety, By offering insights into current state field identifying key areas future research, this aims advance application treatment.
Language: Английский
Citations
0
Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: unknown
Published: May 12, 2025
Currently, treatments such as stem cell transplantation, gene therapy, and anti-inflammatory approaches have shown some promise in addressing spinal cord injury. However, there is still a lack of more effective treatment options. Thus, improved strategies are needed to enhance efficacy promote functional recovery. Exosome-based therapy has emerged promising strategy because exosomes can deliver bioactive molecules, modulate inflammation, tissue regeneration. This review highlights recent advancements the use derived from various types, including mesenchymal cells macrophages, for Exosomes nanoscale vesicles secreted by that involved transporting biomolecules, regulating intercellular communication, reducing inflammatory responses, promoting angiogenesis, providing neuroprotection. The article discusses diagnostic, therapeutic, prognostic roles exosomes, along with administration methods. It mechanisms which different types facilitate injury repair, nerve regeneration, inhibiting apoptosis, an antioxidant stress response. Additionally, emerging techniques engineered targeted delivery systems explored therapeutic specificity. Although exosome faces challenges, need standardized preparation, precise delivery, dose optimization, bioengineered show potential. Overall, exosome-based technology neuroscience offers new perspectives methods treating injury, potential improve recovery patients, thereby warranting future clinical translation.
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Extracellular vesicles are nanoscale released by a diversity of cells that mediate intercellular communication transporting an array biomolecules. They gaining increasing attention in cancer research due to their ability carry specific biomarkers. This characteristic makes them potentially useful for highly sensitive, noninvasive diagnostic procedures and more precise prognostic assessments. Consequently, EVs emerging as transformative tool treatment, facilitating early detection personalized medicine. Despite significant progress, clinical implementation is hindered challenges EV isolation, purification, characterization. However, developing advanced biosensor technologies offers promising solutions these obstacles. review highlights recent progress biosensors analysis, focusing on various sensing modalities including optical, electrochemical, microfluidic, nanomechanical, biological sensors. We also explore techniques characterization, such electron microscopy, atomic force nanoparticle tracking single-particle analysis. Furthermore, the critically assesses associated with put forward future directions, aiming usher cutting-edge era precision medicine through advanced, sensor-based, diagnosis detecting EV-carried
Language: Английский
Citations
0