MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration DOI

Kunyu Zhan,

Keying Zhu,

Bingyan Gu

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 134, С. 112202 - 112202

Опубликована: Май 8, 2024

Язык: Английский

Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway DOI
X Gu, Yong Chen,

Kunyu Cao

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 133, С. 112114 - 112114

Опубликована: Апрель 22, 2024

Язык: Английский

Процитировано

2
Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases DOI Creative Commons
Hong Luo, Yue Lai,

Weili Tang

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 15, 2024

The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction a critical factor in etiology progression these disorders. Therapeutic interventions that incorporate mitochondrial transplantation exhibit considerable promise by increasing numbers improving their functionality. Existing evidence suggests exogenous therapy improves clinical outcomes patients with diseases. This review elucidates abnormalities associated diseases examines mechanisms intercellular transfer artificial transplantation. Furthermore, therapeutic strategies are synthesized, concept engineered proposed.

Язык: Английский

Процитировано

2
Inflammasome-independent pyroptosis DOI
Xing Liu,

Judy Lieberman

Current Opinion in Immunology, Год журнала: 2024, Номер 88, С. 102432 - 102432

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

2
Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis DOI Creative Commons
Xueyan Zhang,

Na Sun,

Yu Huang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 265, С. 115506 - 115506

Опубликована: Сен. 23, 2023

Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder of the nasal mucosa, and impact ozone on AR gaining increasing attention. Although NOD-like receptor thermal protein domain associated 3 (NLRP3) plays a crucial role in pathogenesis AR, its regulatory mechanisms ozone-induced exacerbation remain unclear. Therefore, we explored inhalation inflammation investigated involving NLRP3.Fifty female Sprague-Dawley rats were selected divided into five groups: normal control (NC), with exposure (NE), model, (ARE), ARE treated NLRP3 inhibitor MCC950 (ARE+MCC950). Behavioral changes observed rats, expression NLRP3, active-caspase 1, GSDMD-N was detected by western blotting. The levels interleukin (IL)- 4, IL-5, IL-13, IL-1β, ovalbumin-specific IgE (OVA-sIgE) lavage fluid as well IL-6 serum measured ELISA. distribution IL-1β mucosal tissue immunohistochemistry, pathological eosinophilic infiltration hematoxylin eosin (HE) staining. effects relationship between analyzed.Upregulation rat further aggravated tissue. Compared to NC, NE groups, inflammasomes activated group, related indexes 1 significantly increased; Th2 factors IL-4, OVA-sIgE increased, such also increased. HE staining revealed that damage AR. downregulated, sneezing scratching symptoms reduced, indicators decreased, alleviated ARE+MCC950 group.Ozone increased response animal model can selectively inhibit activity inflammasomes, reduce regulating NLRP3-caspase-1-IL-1β pathway.

Язык: Английский

Процитировано

6
MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration DOI

Kunyu Zhan,

Keying Zhu,

Bingyan Gu

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 134, С. 112202 - 112202

Опубликована: Май 8, 2024

Язык: Английский

Процитировано

1