Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Июнь 27, 2024
Abstract
Background
Traumatic
brain
injury
(TBI)
is
a
significant
risk
factor
for
Alzheimer’s
disease
(AD),
and
accumulating
evidence
supports
role
adaptive
immune
B
T
cells
in
both
TBI
AD
pathogenesis.
We
previously
identified
cell
major
histocompatibility
complex
class
II
(MHCII)-associated
invariant
chain
peptide
(CLIP)-positive
expansion
after
TBI.
also
showed
that
antagonizing
CLIP
binding
to
the
antigen
presenting
groove
of
MHCII
acutely
reduced
+
splenic
was
neuroprotective.
The
current
study
investigated
chronic
effects
5xFAD
mouse
model,
with
without
Methods
12-week-old
male
wild
type
(WT)
mice
were
administered
either
antagonist
(CAP)
or
vehicle,
once
at
30
min
sham
lateral
fluid
percussion
(FPI).
Analyses
included
flow
cytometric
analysis
dural
meninges
spleen,
histopathological
brain,
magnetic
resonance
diffusion
tensor
imaging,
cerebrovascular
analysis,
assessment
motor
neurobehavioral
function
over
ensuing
6
months.
Results
9-month-old
had
significantly
more
compared
age-matched
WT
mice.
A
one-time
treatment
CAP
this
population
Importantly,
improved
some
immune,
histopathological,
impairments
six
Although
FPI
did
not
further
elevate
meningeal
cells,
it
negate
ability
reduce
3
months
age
exacerbated
aspects
pathology
mice,
including
reducing
hippocampal
neurogenesis,
increasing
plaque
deposition
CA3,
altering
microgliosis,
disrupting
structure.
ameliorated
but
all
these
effects.
Язык: Английский
Intruders or protectors – the multifaceted role of B cells in CNS disorders
James W. Aspden,
Matthew A. Murphy,
Rommi D. Kashlan
и другие.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 10, 2024
B
lymphocytes
are
immune
cells
studied
predominantly
in
the
context
of
peripheral
humoral
responses
against
pathogens.
Evidence
has
been
accumulating
recent
years
on
diversity
immunomodulatory
functions
that
undertake,
with
particular
relevance
for
pathologies
central
nervous
system
(CNS).
This
review
summarizes
current
knowledge
cell
populations,
localization,
infiltration
mechanisms,
and
function
CNS
associated
tissues.
Acute
chronic
neurodegenerative
examined
order
to
explore
complex,
sometimes
conflicting,
effects
can
have
each
context,
implications
disease
progression
treatment
outcomes.
Additional
factors
such
as
aging
modulate
proportions
subpopulations
over
time
also
discussed
neuroinflammatory
response
susceptibility.
A
better
understanding
multifactorial
role
populations
may
ultimately
lead
innovative
therapeutic
strategies
a
variety
neurological
conditions.
Язык: Английский
The cross-talk between B cells and macrophages
International Immunopharmacology,
Год журнала:
2024,
Номер
143, С. 113463 - 113463
Опубликована: Окт. 30, 2024
Язык: Английский
B cells in non-lymphoid tissues
Nature reviews. Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Язык: Английский
SIV-specific antibodies protect against inflammasome-driven encephalitis in untreated macaques
Cell Reports,
Год журнала:
2024,
Номер
43(10), С. 114833 - 114833
Опубликована: Окт. 1, 2024
Язык: Английский
Elucidating the neuroimmunology of traumatic brain injury: methodological approaches to unravel intercellular communication and function
Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Дек. 13, 2023
The
neuroimmunology
of
traumatic
brain
injury
(TBI)
has
recently
gained
recognition
as
a
crucial
element
in
the
secondary
pathophysiological
consequences
that
occur
following
neurotrauma.
Both
immune
cells
residing
within
central
nervous
system
(CNS)
and
those
migrating
from
periphery
play
significant
roles
development
injury.
However,
precise
mechanisms
governing
communication
between
innate
adaptive
remain
incompletely
understood,
partly
due
to
limited
utilization
relevant
experimental
models
techniques.
Therefore,
this
discussion,
we
outline
current
methodologies
can
aid
exploration
TBI
neuroimmunology,
with
particular
emphasis
on
interactions
resident
neuroglial
recruited
lymphocytes.
These
techniques
encompass
adoptive
cell
transfer,
intra-CNS
injection(s),
selective
cellular
depletion,
genetic
manipulation,
molecular
neuroimaging,
well
vitro
co-culture
systems
organoid
models.
By
incorporating
key
elements
both
immunity,
these
methods
facilitate
examination
clinically
interactions.
In
addition
preclinical
approaches,
also
detail
an
emerging
avenue
research
seeks
leverage
human
biofluids.
This
approach
enables
investigation
how
infiltrating
modulate
responses
after
TBI.
Considering
growing
significance
neuroinflammation
TBI,
introduction
application
advanced
will
be
pivotal
advancing
translational
field.
Язык: Английский
Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts
The Anatomical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 8, 2024
Abstract
The
meninges
and
associated
vasculature
(MAV)
play
a
crucial
role
in
maintaining
cerebral
integrity
homeostasis.
Recent
advances
transcriptomic
analysis
have
illuminated
the
significance
of
MAV
understanding
complex
physiological
interactions
at
interface
between
skull
brain
after
exposure
to
mechanical
stress.
To
investigate
how
responses
may
confer
resilience
against
repetitive
stress,
we
performed
first
avian
tissues
using
Downy
Woodpecker
(
Dryobates
pubescens
)
Tufted
Titmouse
Baeolophus
bicolor
as
comparison
species.
Our
findings
reveal
divergences
gene
expression
profiles
related
immune
response,
cellular
stress
management,
protein
translation
machinery.
male
woodpeckers
exhibit
tailored
modulation
strategy
that
potentially
dampens
neuroinflammation
while
preserving
protective
immunity.
Overrepresented
genes
involved
suggest
enhanced
mechanisms
for
mitigating
damage
promoting
repair.
Additionally,
enrichment
translation‐associated
pathways
hints
increased
capacity
turnover
remodeling
vital
recovery.
study
not
only
fills
critical
gap
neurobiology
but
also
lays
groundwork
research
comparative
neuroprotection.
Язык: Английский
Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 19, 2024
Abstract
Natural
Killer
(NK)
cells
lose
their
effector
functions
towards
dangerous
in
chronic
inflammatory
diseases
through
still
elusive
mechanisms.
Here,
we
demonstrate
that
Interleukin
35
(IL-35),
an
immunosuppressive
member
of
the
IL-12
family,
inhibits
human
NK
cell
proliferation,
pro-inflammatory,
and
cytotoxic
functions,
while
promoting
secretion
TGF-β
proangiogenic
factors.
Furthermore,
prolonged
exposure
to
IL-35
converts
into
ILC1-like
with
tissue
residency
features
(CD9
+
CD103
CD49a
)
low
was
dependent
on
autocrine
TGF-β.
Single
RNAseq
analysis
also
revealed
heterogeneity
associated
initial
subpopulation,
conventional
or
adaptive,
undergoing
conversion.
Overall,
our
findings
identify
a
new
role
as
key
driver
plasticity
leading
acquisition
weakened
might
play
physiopathological
contexts
represent
attractive
target
for
future
immunotherapies
improve
clinical
activity.
Язык: Английский
Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis
The FASEB Journal,
Год журнала:
2024,
Номер
38(13)
Опубликована: Июль 5, 2024
Abstract
Amyotrophic
lateral
sclerosis
(ALS)
is
an
orphan
neurodegenerative
disease.
Immune
system
dysregulation
plays
essential
role
in
ALS
onset
and
progression.
Our
preclinical
studies
have
shown
that
the
administration
of
exogenous
allogeneic
B
cells
improves
outcomes
murine
models
skin
brain
injury
through
a
process
termed
pligodraxis,
which
adopt
immunoregulatory
neuroprotective
phenotype
injured
environment.
Here,
we
investigated
effects
B‐cell
therapy
SOD1
G93A
mouse
model
person
living
with
ALS.
Purified
splenic
mature
naïve
from
haploidentical
donor
mice
were
administered
intravenously
for
total
10
weekly
doses.
For
clinical
study
advanced
ALS,
IgA
gammopathy
unclear
significance,
lymphopenia,
CD19
+
positively
selected
healthy
infused
twice,
at
60‐day
interval.
Repeated
intravenous
was
safe
significantly
delayed
disease
onset,
extended
survival,
reduced
cellular
apoptosis,
decreased
astrogliosis
mice.
infusion
did
not
appear
to
generate
clinically
evident
inflammatory
response.
An
improvement
5
points
on
ALSFRS‐R
scale
observed
after
first
infusion.
Levels
markers
showed
persistent
reduction
post‐infusion.
This
represents
demonstration
efficacy
safety
feasibility
using
purified
lymphocytes
as
cell‐based
therapeutic
strategy
Язык: Английский