Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 7, 2025
Mitochondrial
dysfunction
is
a
pivotal
instigator
of
neuroinflammation,
with
mitochondrial
DNA
(mtDNA)
leakage
as
critical
intermediary.
This
review
delineates
the
intricate
pathways
leading
to
mtDNA
release,
which
include
membrane
permeabilization,
vesicular
trafficking,
disruption
homeostatic
regulation,
and
abnormalities
in
dynamics.
The
escaped
activates
cytosolic
sensors,
especially
cyclic
gmp-amp
synthase
(cGAS)
signalling
inflammasome,
initiating
neuroinflammatory
cascades
via
pathways,
exacerbating
spectrum
neurological
pathologies.
therapeutic
promise
targeting
discussed
detail,
underscoring
necessity
for
multifaceted
strategy
that
encompasses
preservation
homeostasis,
prevention
leakage,
reestablishment
dynamics,
inhibition
activation
sensors.
Advancing
our
understanding
complex
interplay
between
neuroinflammation
imperative
developing
precision
interventions
disorders.
Язык: Английский
Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 6, 2025
Traumatic
brain
injury
(TBI)
represents
a
significant
global
public
health
issue,
with
effective
management
posing
numerous
challenges.
The
pathophysiology
of
TBI
is
typically
categorized
into
two
phases:
primary
and
secondary
injuries.
Secondary
involves
pathophysiological
mechanisms
such
as
blood-brain
barrier
(BBB)
disruption,
mitochondrial
dysfunction,
oxidative
stress,
inflammatory
responses.
Current
pharmacological
strategies
often
encounter
obstacles
in
treating
effectively,
primarily
due
to
challenges
BBB
penetration,
inadequate
target
site
accumulation,
off-target
toxicity.
Versatile
hydrogels
nanoparticles
offer
potential
solutions
these
limitations.
This
review
discusses
recent
progress
utilizing
for
treatment
over
the
past
5
years,
highlighting
their
relevance
underlying
pathophysiology.
Hydrogels
demonstrate
substantial
promise
addressing
injury,
providing
broad
spectrum
future
therapeutic
opportunities.
Язык: Английский
Role of inflammasomes and neuroinflammation in epilepsy
Immunological Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 10, 2024
Epilepsy
is
a
brain
disorder
characterized
by
recurrent
seizures,
which
are
brief
episodes
of
abnormal
electrical
activity
in
the
and
involuntary
movement
that
can
lead
to
physical
injury
loss
consciousness.
Seizures
canonically
accompanied
increased
inflammatory
cytokine
production
promotes
neuroinflammation,
pathology,
seizure
propagation.
Understanding
source
pro-inflammatory
cytokines
promote
pathogenesis
could
be
gateway
precision
epilepsy
drug
design.
This
review
discusses
inflammasome
including
its
role
propagation
negative
impacts
on
health.
The
multiprotein
complex
coordinates
IL-1β
IL-18
response
tissue
damage,
cellular
stress,
infection.
Clinical
evidence
for
signaling
epileptogenesis
reviewed
followed
discussion
emerging
strategies
modulate
epilepsy.
Язык: Английский