Chemico-Biological Interactions, Год журнала: 2024, Номер 406, С. 111358 - 111358
Опубликована: Дек. 21, 2024
Язык: Английский
Medicinal Research Reviews, Год журнала: 2024, Номер 44(6), С. 2825 - 2848
Опубликована: Авг. 9, 2024
Oxidative DNA damage-related diseases, such as incurable inflammation, malignant tumors, and age-related disorders, present significant challenges in modern medicine due to their complex molecular mechanisms limitations identifying effective treatment targets. Recently, 8-oxoguanine glycosylase 1 (OGG1) has emerged a promising multifunctional therapeutic target for the of these challenging diseases. In this review, we systematically summarize multiple functions OGG1, including pro-inflammatory, tumorigenic, aging regulatory mechanisms. We also highlight potential OGG1 inhibitors activators potent agents aforementioned life-limiting conclude that serves hub; inhibition may provide novel approach preventing treating inflammation cancer, activation could be strategy disorders. Furthermore, an extensive overview successful applications regulation inflammatory, cancerous, aging-related Finally, discuss current future directions emerging marker The aim review is robust reference scientific researchers clinical drug developers development targeted drugs especially
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5580 - 5580
Опубликована: Май 21, 2024
Gut-dysbiosis-induced lipopolysaccharides (LPS) translocation into systemic circulation has been suggested to be implicated in nonalcoholic fatty liver disease (NAFLD) pathogenesis. This study aimed assess if oleuropein (OLE), a component of extra virgin olive oil, lowers high-fat-diet (HFD)-induced endotoxemia and, eventually, steatosis. An immunohistochemistry analysis the intestine and was performed (i) control mice (CTR; n = 15), (ii) fed (HFD) (HFD; 16), (iii) HFD treated with 6 µg/day OLE for 30 days (HFD + OLE, 13). The developed significant steatosis compared controls, an effect that significantly reduced OLE-treated mice. amount hepatocyte LPS localization number TLR4+ macrophages were higher than controls lowered CD42b+ platelets increased sinusoids decreased Compared HFD-treated showed high percentage PAS+ goblet cells, length intestinal crypts, expression, occludin downregulation, counteracted HFD-fed animals displayed levels zonulin, but they animals. It can seen administration improves inflammation association circulation, TLR4 downregulation HFD-induced mouse model NAFLD.
Язык: Английский
Процитировано
5
Journal of Cardiovascular Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Ischemeia-reperfusion (I/R) injury is a severe complication after restoring blood perfusion in acute myocardial infarction treatment, which vascular endothelial cell dysfunction considered as the key event to exacerbate injury. We have previously verified protective function of ZNF580 cells, however, impact on I/R and its underlying mechanisms not been explored depth. The purpose present study investigate regulatory role confirm that potential therapeutic candidate for treatment. mechanism was determined via bioinformatics. A model human umbilical vein cells (HUVECs) subsequently established whether protects against this effect exerted through regulation autophagic flow. Our identified 459 differentially expressed genes (DEGs) increased viability gradually restored morphology, cytoplasm full, intracellular structure clear, space significantly reduced HUVECs exposed Both Western blotting reverse transcription-polymerase chain reaction (RT-qPCR) were used detect levels different apoptosis-related proteins, it shown lysosome-associated membrane protein 2 (LAMP2) light 3 (LC3) expressions, markedly decreased 62 (P62) expression. Moreover, lactate dehydrogenase (LDH) supernatant rate apoptosis. promoted autophagosome lysosome fusion flux, thereby protecting from Its possibly related activation adenosine 5'-monophosphate (AMP)-activated kinase (AMPK) signaling pathway.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2667 - 2667
Опубликована: Март 16, 2025
Cardiovascular disease (CVD) is a serious global health issue with high mortality rates worldwide. Despite the numerous advancements in study of CVD pathogenesis recent years, further summarization and elaboration specific molecular pathways are required. An extensive body research has been conducted to elucidate association between MAPK signaling pathway, which present all eukaryotic organisms, cardiovascular disease. This review aims provide comprehensive summary on over past five years. The primary focus four diseases: heart failure, atherosclerosis, myocardial ischemia–reperfusion injury, cardiac hypertrophy. will also address pathophysiological mechanisms diseases, objective proposing novel clinical treatment strategies for CVD.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156783 - 156783
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Open Life Sciences, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 1, 2024
Diabetic cardiomyopathy (DCM) is identified as a progressive disease that may lead to irreparable heart failure. Toll-like receptor (TLR) signaling believed be implicated in the pathogenesis of DCM. This study intended explore potential impact 4 (TLR4) on DCM
Язык: Английский
Процитировано
1
Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(12), С. 106014 - 106014
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
1
Food Science and Biotechnology, Год журнала: 2024, Номер 33(15), С. 3629 - 3637
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
0
Chemico-Biological Interactions, Год журнала: 2024, Номер 406, С. 111358 - 111358
Опубликована: Дек. 21, 2024
Язык: Английский
Процитировано
0