Identification of VDAC1 as a cardioprotective target of Ginkgolide B DOI

Tingbiao Wu,

Deyao Li,

Q. Chen

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 406, P. 111358 - 111358

Published: Dec. 21, 2024

Language: Английский

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage DOI Creative Commons

Yunxiao Zhong,

Xinya Zhang, Ruibing Feng

et al.

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(6), P. 2825 - 2848

Published: Aug. 9, 2024

Oxidative DNA damage-related diseases, such as incurable inflammation, malignant tumors, and age-related disorders, present significant challenges in modern medicine due to their complex molecular mechanisms limitations identifying effective treatment targets. Recently, 8-oxoguanine glycosylase 1 (OGG1) has emerged a promising multifunctional therapeutic target for the of these challenging diseases. In this review, we systematically summarize multiple functions OGG1, including pro-inflammatory, tumorigenic, aging regulatory mechanisms. We also highlight potential OGG1 inhibitors activators potent agents aforementioned life-limiting conclude that serves hub; inhibition may provide novel approach preventing treating inflammation cancer, activation could be strategy disorders. Furthermore, an extensive overview successful applications regulation inflammatory, cancerous, aging-related Finally, discuss current future directions emerging marker The aim review is robust reference scientific researchers clinical drug developers development targeted drugs especially

Language: Английский

Citations

8
Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation DOI Open Access
Leonardo Schirone, Diletta Overi, Guido Carpino

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5580 - 5580

Published: May 21, 2024

Gut-dysbiosis-induced lipopolysaccharides (LPS) translocation into systemic circulation has been suggested to be implicated in nonalcoholic fatty liver disease (NAFLD) pathogenesis. This study aimed assess if oleuropein (OLE), a component of extra virgin olive oil, lowers high-fat-diet (HFD)-induced endotoxemia and, eventually, steatosis. An immunohistochemistry analysis the intestine and was performed (i) control mice (CTR; n = 15), (ii) fed (HFD) (HFD; 16), (iii) HFD treated with 6 µg/day OLE for 30 days (HFD + OLE, 13). The developed significant steatosis compared controls, an effect that significantly reduced OLE-treated mice. amount hepatocyte LPS localization number TLR4+ macrophages were higher than controls lowered CD42b+ platelets increased sinusoids decreased Compared HFD-treated showed high percentage PAS+ goblet cells, length intestinal crypts, expression, occludin downregulation, counteracted HFD-fed animals displayed levels zonulin, but they animals. It can seen administration improves inflammation association circulation, TLR4 downregulation HFD-induced mouse model NAFLD.

Language: Английский

Citations

5
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy DOI
Xiaoting Yang, Hui Wu,

Di Liu

et al.

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

0
Identification and Analysis of the Role of Zinc Finger Protein 580 in Ischemeia–Reperfusion Injury through Bioinformatics and Experimental Verification DOI Creative Commons

Zhongbai Zhang,

Xueting Qin,

Jiyuan Liu

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Ischemeia-reperfusion (I/R) injury is a severe complication after restoring blood perfusion in acute myocardial infarction treatment, which vascular endothelial cell dysfunction considered as the key event to exacerbate injury. We have previously verified protective function of ZNF580 cells, however, impact on I/R and its underlying mechanisms not been explored depth. The purpose present study investigate regulatory role confirm that potential therapeutic candidate for treatment. mechanism was determined via bioinformatics. A model human umbilical vein cells (HUVECs) subsequently established whether protects against this effect exerted through regulation autophagic flow. Our identified 459 differentially expressed genes (DEGs) increased viability gradually restored morphology, cytoplasm full, intracellular structure clear, space significantly reduced HUVECs exposed Both Western blotting reverse transcription-polymerase chain reaction (RT-qPCR) were used detect levels different apoptosis-related proteins, it shown lysosome-associated membrane protein 2 (LAMP2) light 3 (LC3) expressions, markedly decreased 62 (P62) expression. Moreover, lactate dehydrogenase (LDH) supernatant rate apoptosis. promoted autophagosome lysosome fusion flux, thereby protecting from Its possibly related activation adenosine 5'-monophosphate (AMP)-activated kinase (AMPK) signaling pathway.

Language: Английский

Citations

0
The Role of the MAPK Signaling Pathway in Cardiovascular Disease: Pathophysiological Mechanisms and Clinical Therapy DOI Open Access
Xueyang Wang, Ruiqi Liu, Dan Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2667 - 2667

Published: March 16, 2025

Cardiovascular disease (CVD) is a serious global health issue with high mortality rates worldwide. Despite the numerous advancements in study of CVD pathogenesis recent years, further summarization and elaboration specific molecular pathways are required. An extensive body research has been conducted to elucidate association between MAPK signaling pathway, which present all eukaryotic organisms, cardiovascular disease. This review aims provide comprehensive summary on over past five years. The primary focus four diseases: heart failure, atherosclerosis, myocardial ischemia–reperfusion injury, cardiac hypertrophy. will also address pathophysiological mechanisms diseases, objective proposing novel clinical treatment strategies for CVD.

Language: Английский

Citations

0
Natural products and ferroptosis: A novel approach for heart failure management DOI
Zeyu Zhang, Zhihua Yang, Shuai Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156783 - 156783

Published: April 1, 2025

Language: Английский

Citations

0
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway DOI Creative Commons
Xiaolong Zhao, Jing Zhang, Feng Xu

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Diabetic cardiomyopathy (DCM) is identified as a progressive disease that may lead to irreparable heart failure. Toll-like receptor (TLR) signaling believed be implicated in the pathogenesis of DCM. This study intended explore potential impact 4 (TLR4) on DCM

Language: Английский

Citations

1
Biological evaluation of sophoridine by interaction with plasma transport protein and protective effects in cardiomyocytes DOI Creative Commons

Zheng Wu,

Shujuan Cheng,

Shaoping Wang

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106014 - 106014

Published: Oct. 9, 2024

Language: Английский

Citations

1
Sinapine suppresses ROS-induced C2C12 myoblast cell death through MAPK and autophagy pathways DOI
Jeonghyun Kang, Dong Hwan Kim, Jin Cheol Yoo

et al.

Food Science and Biotechnology, Journal Year: 2024, Volume and Issue: 33(15), P. 3629 - 3637

Published: Sept. 30, 2024

Language: Английский

Citations

0
Identification of VDAC1 as a cardioprotective target of Ginkgolide B DOI

Tingbiao Wu,

Deyao Li,

Q. Chen

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 406, P. 111358 - 111358

Published: Dec. 21, 2024

Language: Английский

Citations

0