Drug Resistance Updates,
Год журнала:
2023,
Номер
72, С. 101018 - 101018
Опубликована: Ноя. 11, 2023
Cuproptosis
is
a
newly
identified
form
of
cell
death
driven
by
copper.
Recently,
the
role
copper
and
triggered
in
pathogenesis
cancers
have
attracted
attentions.
has
garnered
enormous
interest
cancer
research
communities
because
its
great
potential
for
therapy.
Copper-based
treatment
exerts
an
inhibiting
tumor
growth
may
open
door
chemotherapy-insensitive
tumors.
In
this
review,
we
provide
critical
analysis
on
homeostasis
dysregulation
development
progression
cancers.
Then
core
molecular
mechanisms
cuproptosis
discussed,
followed
summarizing
current
understanding
copper-based
agents
(copper
chelators,
ionophores,
complexes-based
dynamic
therapy)
treatment.
Additionally,
summarize
emerging
data
ionophores
to
subdue
chemotherapy
resistance
different
types
We
also
review
small-molecule
compounds
nanoparticles
(NPs)
that
kill
cells
inducing
cuproptosis,
which
will
shed
new
light
anticancer
drugs
through
future.
Finally,
important
concepts
pressing
questions
future
should
be
focused
were
discussed.
This
article
suggests
targeting
could
novel
antitumor
therapy
strategy
overcome
drug
resistance.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 16, 2023
Abstract
Regulated
cell
death
(RCD)
is
a
regulable
that
involves
well-organized
signaling
cascades
and
molecular
mechanisms.
RCD
implicated
in
fundamental
processes
such
as
organ
production
tissue
remodeling,
removing
superfluous
structures
or
cells,
regulating
numbers.
Previous
studies
have
not
been
able
to
reveal
the
complete
mechanisms,
novel
methods
of
are
constantly
being
proposed.
Two
metal
ions,
iron
(Fe)
copper
(Cu)
essential
factors
leading
RCDs
only
induce
ferroptosis
cuproptosis,
respectively
but
also
lead
impairment
eventually
diverse
death.
This
review
summarizes
direct
indirect
mechanisms
by
which
Fe
Cu
impede
growth
various
forms
mediated
these
two
metals.
Moreover,
we
aimed
delineate
interrelationships
between
with
distinct
pathways
shedding
light
on
complex
intricate
govern
cellular
survival
Finally,
prospects
outlined
this
suggest
approach
for
investigating
death,
may
involve
integrating
current
therapeutic
strategies
offer
promising
solution
overcome
drug
resistance
certain
diseases.
Immunological Reviews,
Год журнала:
2023,
Номер
321(1), С. 211 - 227
Опубликована: Сен. 16, 2023
Summary
Copper
is
an
essential
nutrient
for
maintaining
enzyme
activity
and
transcription
factor
function.
Excess
copper
results
in
the
aggregation
of
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
which
correlates
to
mitochondrial
tricarboxylic
acid
(TCA)
cycle,
resulting
proteotoxic
stress
eliciting
a
novel
cell
death
modality:
cuproptosis.
Cuproptosis
exerts
indispensable
role
cancer
progression,
considered
promising
strategy
therapy.
Cancer
immunotherapy
has
gained
extensive
attention
owing
breakthroughs
immune
checkpoint
blockade;
furthermore,
cuproptosis
strongly
connected
modulation
antitumor
immunity.
Thus,
thorough
recognition
concerning
mechanisms
involved
metabolism
may
facilitate
improvement
management.
This
review
outlines
cellular
molecular
characteristics
links
regulated
modality
with
human
cancers.
We
also
current
knowledge
on
complex
effects
immunity
response.
Furthermore,
potential
agents
that
elicit
pathways
are
summarized.
Lastly,
we
discuss
influence
induction
tumor
microenvironment
as
well
challenges
adding
regulators
therapeutic
strategies
beyond
traditional
Abstract
The
recent
discovery
of
copper‐mediated
and
mitochondrion‐dependent
cuproptosis
has
aroused
strong
interest
in
harnessing
this
novel
mechanism
cell
death
for
cancer
therapy.
Here
the
design
a
core‐shell
nanoparticle,
CuP/Er,
co‐delivery
copper
(Cu)
erastin
(Er)
to
cells
synergistic
ferroptosis
is
reported.
anti‐Warburg
effect
Er
sensitizes
tumor
Cu‐mediated
cuproptosis,
leading
irreparable
mitochondrial
damage
by
depleting
glutathione
enhancing
lipid
peroxidation.
CuP/Er
induces
immunogenic
death,
enhances
antigen
presentation,
upregulates
programmed
death‐ligand
1
expression.
Consequently,
promotes
proliferation
infiltration
T
cells,
when
combined
with
immune
checkpoint
blockade,
effectively
reinvigorates
mediate
regression
murine
colon
adenocarcinoma
triple‐negative
breast
prevent
metastasis.
This
study
suggests
unique
opportunity
synergize
combination
therapy
nanoparticles
elicit
antitumor
effects
potentiate
current
immunotherapies.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
171, С. 116115 - 116115
Опубликована: Янв. 5, 2024
Ferroptosis
and
cuproptosis,
regulated
forms
of
cell
death
resulting
from
metal
ion
accumulation,
are
closely
related
in
terms
occurrence,
metabolism,
signaling
pathways,
drug
resistance.
Notably,
it
is
now
understood
that
these
processes
play
crucial
roles
regulating
physiological
pathological
processes,
especially
tumor
development.
Consequently,
ferroptosis
cuproptosis
have
gained
increasing
significance
as
potential
targets
for
anti-cancer
This
article
systematically
outlines
the
molecular
mechanisms
cross-talk
components
both
elucidating
their
impacts
on
cancer.
Furthermore,
investigates
clinical
perspective
targeted
cancer
chemotherapy,
immunotherapy,
radiotherapy.
Our
discussion
extends
to
a
comparative
analysis
nanoparticles
developed
based
cancer,
contrasting
them
with
current
conventional
therapies.
Opportunities
challenges
treatment
explored,
emphasizing
therapeutic
direction
co-targeting
cuproptosis.
The
also
attempts
analyze
applications
this
approach
while
summarizing
existing
barriers
require
overcoming.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июнь 6, 2024
Abstract
Ferroptosis,
an
iron-dependent
form
of
cell
death
characterized
by
uncontrolled
lipid
peroxidation,
is
governed
molecular
networks
involving
diverse
molecules
and
organelles.
Since
its
recognition
as
a
non-apoptotic
pathway
in
2012,
ferroptosis
has
emerged
crucial
mechanism
numerous
physiological
pathological
contexts,
leading
to
significant
therapeutic
advancements
across
wide
range
diseases.
This
review
summarizes
the
fundamental
mechanisms
regulatory
pathways
underlying
ferroptosis,
including
both
GPX4-dependent
-independent
antioxidant
mechanisms.
Additionally,
we
examine
involvement
various
conditions,
cancer,
neurodegenerative
diseases,
sepsis,
ischemia–reperfusion
injury,
autoimmune
disorders,
metabolic
disorders.
Specifically,
explore
role
response
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy,
targeted
therapy.
Furthermore,
discuss
pharmacological
strategies
for
modulating
potential
biomarkers
monitoring
this
process.
Lastly,
elucidate
interplay
between
other
forms
regulated
death.
Such
insights
hold
promise
advancing
our
understanding
context
human
health
disease.
Disruptions
in
metal
balance
can
trigger
a
synergistic
interplay
of
cuproptosis
and
ferroptosis,
offering
promising
solutions
to
enduring
challenges
oncology.
Here,
we
have
engineered
Cellular
Trojan
Horse,
named
MetaCell,
which
uses
live
neutrophils
stably
internalize
thermosensitive
liposomal
bimetallic
Fe-Cu
MOFs
(Lip@Fe-Cu-MOFs).
MetaCell
instigate
thereby
enhancing
treatment
efficacy.
Mirroring
the
characteristics
neutrophils,
evade
immune
system
not
only
infiltrate
tumors
but
also
respond
inflammation
by
releasing
therapeutic
components,
surmounting
traditional
barriers.
Notably,
Lip@Fe-Cu-MOFs
demonstrate
notable
photothermal
effects,
inciting
targeted
release
Fe-Cu-MOFs
within
cancer
cells
amplifying
action
ferroptosis.
has
demonstrated
outcomes
tumor-bearing
mice,
effectively
eliminating
solid
forestalling
recurrence,
leading
extended
survival.
This
research
provides
great
insights
into
complex
between
copper
iron
homeostasis
malignancies,
potentially
paving
way
for
innovative
approaches
treatment.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Апрель 23, 2024
Abstract
Tumor
is
a
local
tissue
hyperplasia
resulted
from
cancerous
transformation
of
normal
cells
under
the
action
various
physical,
chemical
and
biological
factors.
The
exploration
tumorigenesis
mechanism
crucial
for
early
prevention
treatment
tumors.
Epigenetic
modification
common
important
in
cells,
including
DNA
methylation,
histone
modification,
non-coding
RNA
m6A
modification.
mode
cell
death
programmed
by
death-related
genes;
however,
recent
researches
have
revealed
some
new
modes
death,
pyroptosis,
ferroptosis,
cuproptosis
disulfidptosis.
regulation
deaths
mainly
involved
key
proteins
affects
up-regulating
or
down-regulating
expression
levels
proteins.
This
study
aims
to
investigate
epigenetic
modifications
regulating
disulfidptosis
tumor
explore
possible
triggering
factors
development
microscopic
point
view,
provide
potential
targets
therapy
perspective
antitumor
drugs
combination
therapies.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 5, 2024
Abstract
Copper
is
a
crucial
trace
element
that
plays
role
in
various
pathophysiological
processes
the
human
body.
also
acts
as
transition
metal
involved
redox
reactions,
contributing
to
generation
of
reactive
oxygen
species
(ROS).
Under
prolonged
and
increased
ROS
levels,
oxidative
stress
occurs,
which
has
been
implicated
different
types
regulated
cell
death.
The
recent
discovery
cuproptosis,
copper-dependent
death
pathway
distinct
from
other
known
forms,
raised
interest
researchers
field
cancer
therapy.
Herein,
present
work
aims
outline
current
understanding
with
an
emphasis
on
its
anticancer
activities
through
interplay
copper-induced
stress,
thereby
providing
new
ideas
for
therapeutic
approaches
targeting
modes
future.
Cancers,
Год журнала:
2024,
Номер
16(3), С. 512 - 512
Опубликована: Янв. 24, 2024
Iron
(Fe)
and
copper
(Cu),
essential
transition
metals,
play
pivotal
roles
in
various
cellular
processes
critical
to
cancer
biology,
including
cell
proliferation,
mitochondrial
respiration,
distant
metastases,
oxidative
stress.
The
emergence
of
ferroptosis
cuproptosis
as
distinct
forms
non-apoptotic
death
has
heightened
their
significance,
particularly
connection
with
these
metal
ions.
While
initially
studied
separately,
recent
evidence
underscores
the
interdependence
cuproptosis.
Studies
reveal
a
link
between
accumulation
induction.
This
interconnected
relationship
presents
promising
strategy,
especially
for
addressing
refractory
cancers
marked
by
drug
tolerance.
Harnessing
toxicity
iron
clinical
settings
becomes
crucial.
Simultaneous
targeting
cuproptosis,
exemplified
combination
sorafenib
elesclomol-Cu,
represents
an
intriguing
approach.
Strategies
mitochondria
further
enhance
precision
approaches,
providing
hope
improving
treatment
outcomes
drug-resistant
cancers.
Moreover,
chelators
copper-lowering
agents
established
therapeutic
modalities
exhibits
synergy
that
holds
promise
augmentation
anti-tumor
efficacy
malignancies.
review
elaborates
on
complex
interplay
underlying
mechanisms,
explores
potential
druggable
targets
both
research
settings.
