The LncRNA AK018453 regulates TRAP1/Smad signaling in IL‐17‐activated astrocytes: A potential role in EAE pathogenesis DOI

Qingxiu Zhang,

Ying Yang, Yingyu Chen

и другие.

Glia, Год журнала: 2022, Номер 70(11), С. 2079 - 2092

Опубликована: Июль 2, 2022

Abstract The pro‐inflammatory cytokine interleukin 17 (IL‐17), that is mainly produced by Th17 cells, has been recognized as a key regulator in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Reactive astrocytes stimulated proinflammatory cytokines including IL‐17 are involved blood brain barrier destruction, inflammatory cells infiltration spinal cord injury. However, the role of long non‐coding RNAs (lncRNAs) induced pathogenesis MS EAE remains unknown. Herein, we found an IL‐17‐induced lncRNA AK018453 promoted TGF‐β receptor‐associated protein 1 (TRAP1) expression Smad‐dependent signaling mouse primary astrocytes. Knockdown significantly suppressed astrocytosis, attenuated phosphorylation Smad2/3, reduced NF‐κB p65 CBP/P300 binding to TRAP1 promoter, diminished production IL‐17‐treated knockdown lentiviral vector vivo dramatically inhibited inflammation prevented mice from demyelination during progression EAE. Together, these results suggest regulates IL‐17‐dependent response reactive potentially promotes via TRAP1/Smad pathway. Targeting this pathway may have therapeutic potential for intervening demyelinating diseases.

Язык: Английский

Epigenetics in Health and Disease DOI
Lian Zhang, Qianjin Lu, Christopher Chang

и другие.

Advances in experimental medicine and biology, Год журнала: 2020, Номер unknown, С. 3 - 55

Опубликована: Янв. 1, 2020

Язык: Английский

Процитировано

506
Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications DOI
Ola Elazazy,

Heba M. Midan,

Reem K. Shahin

и другие.

Pathology - Research and Practice, Год журнала: 2023, Номер 246, С. 154512 - 154512

Опубликована: Май 9, 2023

Язык: Английский

Процитировано

49
Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases DOI Creative Commons
Valeria Lodde,

Giampaolo Murgia,

Elena Rita Simula

и другие.

Biomolecules, Год журнала: 2020, Номер 10(7), С. 1044 - 1044

Опубликована: Июль 14, 2020

Immune responses are essential for the clearance of pathogens and repair injured tissues; however, if these not properly controlled, autoimmune diseases can occur. Autoimmune (ADs) a family disorders characterized by body's immune response being directed against its own tissues, with consequent chronic inflammation tissue damage. Despite enormous efforts to identify new drug targets develop therapies prevent ameliorate AD symptoms, no definitive solutions available today. Additionally, while substantial progress has been made in development some ADs, most treatments only symptoms and, general, ADs still incurable. Hundreds genetic loci have identified associated genome-wide association studies. However, whole list molecular factors that contribute pathogenesis is unknown. Noncoding (nc)RNAs, such as microRNAs, circular (circ)RNAs, long noncoding (lnc)RNAs, regulate gene expression at different levels various diseases, including serve potential well biomarkers disease progression therapy. In this review, we will focus on roles regulation ncRNA four diseases-systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes mellitus.

Язык: Английский

Процитировано

102
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases DOI Creative Commons
Yuanhao Yang, Hannah Musco, Steve Simpson

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Сен. 24, 2021

An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, consistent relationships exist MS the two predominant IBD subtypes, ulcerative colitis (UC) Crohn's (CD), remains unclear. Here, we use large-scale genome-wide study summary data to investigate architecture overall UC CD independently. We find significantly greater correlation than CD, identify three SNPs (rs13428812), (rs116555563) (rs13428812, rs9977672) in cross-trait meta-analyses. suggestive evidence for causal effect of on using Mendelian randomization, no or weak inconsistent MS. observe largely patterns tissue-specific heritability enrichment IBDs lung, spleen, whole blood small intestine, cell-type-specific CD4+ T cells lung CD8+ cytotoxic spleen. Our sheds light biological basis comorbidity IBD.

Язык: Английский

Процитировано

81
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders DOI Creative Commons
Ping Sun,

Milton H. Hamblin,

Ke‐Jie Yin

и другие.

Fluids and Barriers of the CNS, Год журнала: 2022, Номер 19(1)

Опубликована: Март 26, 2022

Abstract The blood–brain barrier (BBB) is an essential component of the neurovascular unit that controls exchanges various biological substances between blood and brain. BBB damage a common feature different central nervous systems (CNS) disorders plays vital role in pathogenesis diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), circular (circRNAs), are important regulatory molecules involved almost all cellular processes normal development diseases, including CNS Cumulative evidences have demonstrated ncRNA regulation functions In this review, we summarized miRNAs, lncRNAs, circRNAs can be served diagnostic prognostic biomarkers for injuries, involvement underlying mechanisms ncRNAs modulating structure function ischemic stroke, hemorrhagic traumatic brain injury (TBI), spinal cord (SCI), multiple sclerosis (MS), Alzheimer's disease (AD), vascular cognitive impairment dementia (VCID), tumors, infections, diabetes, sepsis-associated encephalopathy (SAE), others. We also discussed pharmaceutical drugs regulate via ncRNAs-related signaling cascades disorders, along with challenges, perspective, therapeutic potential

Язык: Английский

Процитировано

45
Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways DOI Open Access
Giovanni Luca Cipriano,

Giovanni Schepici,

Emanuela Mazzon

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2255 - 2255

Опубликована: Фев. 13, 2024

Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and demyelination induced autoreactive immune cells that occur in the Central Nervous System (CNS). The interaction between epigenetic changes genetic factors can be widely involved onset, development, progression of disease. Although numerous efforts were made to discover new therapies able prevent improve course MS, definitive curative treatments have not been found yet. However, recent years, it has reported non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), circular (circRNAs), acting as gene expression regulators, could used potential therapeutic targets or biomarkers diagnose fight MS. In this review, we discussed role miRNAs, lncRNAs, circRNAs, well their level signaling pathways are related preclinical human MS studies. Hence, investigation important provide additional information regarding pathogenesis promote discovery strategies biomarkers.

Язык: Английский

Процитировано

14
Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications DOI Creative Commons
Zhongyu Wang, Zeng-Jin Wen,

Hai-Ming Xu

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Ноя. 9, 2022

Central nervous system (CNS) disease is a general term for series of complex and diverse diseases, including Alzheimer’s (AD), Parkinson’s (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, amyotrophic lateral (ALS). Interneuron neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron by transferring contents, such as proteins, lipids, ncRNAs, constituting novel form cell-to-cell interaction communication. Exosomal noncoding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), PIWI-interacting (piRNAs), regulate physiological functions maintain homeostasis. are regarded extracellular messengers that transfer ncRNAs between neurons body fluids due to ability cross blood-brain barrier. This review aims summarize current understanding exosomal prospective diagnostic biomarkers, pathological regulators, therapeutic strategies clinical applications. We also provide an all-sided discussion comparison some similar diseases main limitations challenges

Язык: Английский

Процитировано

36
Ti3C2@Bi2O3 nanoaccordion for electrochemical determination of miRNA-21 DOI
Ruizhuo Ouyang, Lan Jiang,

Xianjin Xie

и другие.

Microchimica Acta, Год журнала: 2023, Номер 190(2)

Опубликована: Янв. 14, 2023

Язык: Английский

Процитировано

19
Glucose metabolism is controlled by non-coding RNAs in autoimmune diseases; a glimpse into immune system dysregulation DOI
Raed Obaid Saleh,

Raed Fanoukh Aboqader Al-Aouadi,

Nujud Almuzaini

и другие.

Human Immunology, Год журнала: 2025, Номер 86(3), С. 111269 - 111269

Опубликована: Фев. 24, 2025

Язык: Английский

Процитировано

0
LncRNA GAS5 and miR-137 Polymorphisms and Expression are Associated with Multiple Sclerosis Risk: Mechanistic Insights and Potential Clinical Impact DOI
Mahmoud A. Senousy, Olfat Shaker, Noha H. Sayed

и другие.

ACS Chemical Neuroscience, Год журнала: 2020, Номер 11(11), С. 1651 - 1660

Опубликована: Апрель 29, 2020

The pathogenesis of multiple sclerosis (MS) is influenced by the interaction genetic and epigenetic mechanisms. long noncoding RNA GAS5 acts as a competing endogenous for microRNA-137 involved in demyelination. We investigated association miR-137 expression their polymorphisms with MS susceptibility. One hundred eight patients 104 healthy controls were included. Expression analysis genotyping GAS5-rs2067079 miR-137-rs1625579 single nucleotide performed qPCR. Serum was upregulated, while serum downregulated compared controls. an excellent discriminator from (AUC = 0.97) negative independent predictor multivariate logistic analysis. positively correlated expanded disability status scale scores relapsing-remitting patients. rs2067079TT minor homozygote genotype associated increased risk, rs1625579G allele protective. rs1625579 showed age-specific effect, rs2067079 affected risk gender- manners. In patients, higher than other genotypes, did not differ between genotypes. Our results suggest biomarkers, marker severity. propose novel markers susceptibility, at least, possibly impacts crosstalk miR-137.

Язык: Английский

Процитировано

33