Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases

International Immunopharmacology, Год журнала: 2022, Номер 106, С. 108634 - 108634

Опубликована: Фев. 19, 2022

Язык: Английский

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The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 24, 2024

Interleukin-6 (IL-6) is a versatile cytokine crucial for immune response modulation, inflammation regulation, and various physiological processes in the body. Its wide-ranging functions underscore its importance maintaining health. Dysregulated IL-6 closely associated with many diseases, making it key research therapeutic target. Elevated levels central nervous system worsen neuroinflammation neurodegenerative diseases by activating microglia astrocytes releasing pro-inflammatory cytokines neurotoxic molecules. Moreover, dysregulated weakens blood-brain barrier, exacerbating neuronal damage allowing peripheral cells inflammatory mediators to enter brain. Mesenchymal stem (MSCs) show promise modulating regulating levels. They effectively suppress cytokines, including IL-6, while promoting anti-inflammatory factors. This approach highlights of targeting other alleviate adverse effects on neurological disorders. review provides comprehensive overview IL-6’s involvement disorders, examining endogenous derived from MSCs. We explore mechanisms affecting function, survival, modulation system. Additionally, we discuss potential MSC-derived neuroregeneration neuroprotection. By elucidating interplay pathologies, this offers insights into novel strategies signaling pathways

Язык: Английский

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Human umbilical cord derived mesenchymal stem cells overexpressing HO‐1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice

CNS Neuroscience & Therapeutics, Год журнала: 2023, Номер 30(2)

Опубликована: Авг. 17, 2023

Abstract Aims The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following overexpression heme oxygenase‐1 (HO‐1) impact excessive inflammatory activation a mouse stroke model. This study investigated this aspect and provided further insights. Methods middle cerebral artery occlusion (MCAO) model was established, subsequent injections MSC, HO‐1 , or PBS solutions equal volume were administered via mice's tail vein. Histopathological analysis conducted on Days 3 28 post‐MCAO to observe morphological brain slices. mRNA expression levels various factors, including IL‐1β, IL‐6, IL‐17, TNF‐α, IL‐1Ra, IL‐4, IL‐10, TGF‐β, quantified. effects treatment neurons, microglia, astrocytes observed using immunofluorescence after transplantation. polarization direction macrophages/microglia also detected flow cytometry. Results results showed anti‐inflammatory factors group increased while pro‐inflammatory decreased. Small animal fluorescence studies assays homing function MSCs unaffected, leading substantial accumulation region within 24 h. Neurons less damaged, proliferation microglia reduced, M2 type Furthermore, transplantation mortality mice decreased, motor improved significantly. Conclusion findings indicate overexpressing exhibited significant against hyper‐inflammatory injury mice, ultimately promoting recovery

Язык: Английский

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Re-establishing immune tolerance in multiple sclerosis: focusing on novel mechanisms of mesenchymal stem cell regulation of Th17/Treg balance

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 15, 2024

The T-helper 17 (Th17) cell and regulatory T (Treg) axis plays a crucial role in the development of multiple sclerosis (MS), which is regarded as an immune imbalance between pro-inflammatory cytokines maintenance tolerance. Mesenchymal stem (MSC)-mediated therapies have received increasing attention MS research. In its animal model experimental autoimmune encephalomyelitis, MSC injection was shown to alter differentiation CD4

Язык: Английский

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Hematopoiesis during Ontogenesis, Adult Life, and Aging

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(17), С. 9231 - 9231

Опубликована: Авг. 26, 2021

In the bone marrow of vertebrates, two types stem cells coexist—hematopoietic (HSCs) and mesenchymal (MSCs). Hematopoiesis only occurs when these cell their descendants interact. The HSCs supply body with all mature blood cells, while MSCs give rise to stromal that form a niche for regulate process hematopoiesis. studies hematopoiesis were initially based on morphological observations, later extended by use physiological methods, subsequently augmented massive application sophisticated molecular techniques. combination methods produced wealth new data organization functional features in ontogenesis mammals humans. This review summarizes current views mice humans, discusses development elements embryo, describes how hematopoietic system works adult organism it changes during aging.

Язык: Английский

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Concurrently bioprinted scaffolds with autologous bone and allogeneic BMSCs promote bone regeneration through native BMSC recruitment

Bio-Design and Manufacturing, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Язык: Английский

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Idiopathic pulmonary fibrosis microenvironment: Novel mechanisms and research directions

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114653 - 114653

Опубликована: Апрель 14, 2025

Язык: Английский

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Cell therapy with placenta-derived mesenchymal stem cells for secondary progressive multiple sclerosis patients in a phase 1 clinical trial

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 8, 2025

Язык: Английский

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Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection

Digital Health, Год журнала: 2025, Номер 11

Опубликована: Май 1, 2025

Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive motor impairments. Early diagnosis remains a challenge due the slow progression of symptoms limitations current diagnostic methods. Nanobiosensors, leveraging high sensitivity specificity nanotechnology, offer promising, noninvasive, cost-effective approach for detecting disease biomarkers at ultra-low concentrations. This review highlights recent advancements in nanobiosensor technology, integration gold nanoparticles, quantum dots, carbon nanotubes, which have significantly enhanced biomarker detection precision. Furthermore, it examines advantages nanobiosensors over traditional techniques, such as improved sensitivity, rapid detection, minimal invasiveness. The potential these innovative sensors revolutionize early improve patient outcomes is discussed, along with existing challenges clinical translation, stability, reproducibility, regulatory considerations. Addressing will be crucial integrating into routine practice advancing personalized medicine neurodegenerative disorders.

Язык: Английский

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Universal or Personalized Mesenchymal Stem Cell Therapies: Impact of Age, Sex, and Biological Source

Cells, Год журнала: 2022, Номер 11(13), С. 2077 - 2077

Опубликована: Июнь 30, 2022

Mesenchymal stem/stromal cells (MSCs) hold great promise for the treatment of autoimmune conditions given their immunomodulatory properties. Based on low immunogenicity MSCs, it is tempting to consider expansion MSCs from a “universal donor” in culture prior allogeneic applications immediate care. This raises critical question criteria we should use select best donor”. It also imperative compare “universal” approach with “personalized” one clinical value. In addition call MHC-matching, recent studies suggest that factors including age, sex, and biological sources can have significant impact therapy outcome. Here, will review findings these studies, which shed light variables guide important choice or MSC diseases.

Язык: Английский

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