Molecular Neurobiology,
Год журнала:
2024,
Номер
61(9), С. 7092 - 7108
Опубликована: Фев. 17, 2024
Abstract
Parkinson’s
disease
(PD)
is
a
progressive
neurodegenerative
of
the
brain
due
to
degeneration
dopaminergic
neurons
in
substantia
nigra
(SN).
Glycogen
synthase
kinase
3
beta
(GSK-3β)
implicated
pathogenesis
PD.
Therefore,
purpose
present
review
was
revise
mechanistic
role
GSK-3β
PD
neuropathology,
and
how
inhibitors
affect
neuropathology.
GSK-3
conserved
threonine/serine
protein
that
intricate
regulation
cellular
anabolic
catabolic
pathways
by
modulating
glycogen
synthase.
Over-expression
also
interconnected
with
development
different
diseases.
However,
underlying
mechanism
neuropathology
not
fully
clarified.
induces
triggering
mitochondrial
dysfunction
oxidative
stress
SN.
NF-κB
NLRP3
inflammasome
are
activated
response
dysregulated
leading
neuronal
injury.
Higher
expression
early
stages
might
contribute
reduction
neuroprotective
brain-derived
neurotrophic
factor
(BDNF).
Thus,
may
be
effective
reducing
inflammatory
disorders
which
associated
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 1869 - 1869
Опубликована: Янв. 18, 2023
Aging
is
the
most
prominent
risk
factor
for
late-onset
Alzheimer’s
disease.
associates
with
a
chronic
inflammatory
state
both
in
periphery
and
central
nervous
system,
evidence
thereof
mechanisms
leading
to
neuroinflammation
being
discussed.
Nonetheless,
significantly
enhanced
by
accumulation
of
amyloid
beta
accelerates
progression
disease
through
various
pathways
discussed
present
review.
Decades
clinical
trials
targeting
2
abnormal
proteins
disease,
tau,
led
many
failures.
As
such,
via
different
strategies
could
prove
valuable
therapeutic
strategy,
although
much
research
still
needed
identify
appropriate
time
window.
Active
focusing
on
identifying
early
biomarkers
help
translating
these
novel
from
bench
bedside.
Nature Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Alzheimer's
disease
(AD)
is
the
leading
cause
of
dementia
in
older
adults.
Although
AD
progression
characterized
by
stereotyped
accumulation
proteinopathies,
affected
cellular
populations
remain
understudied.
Here
we
use
multiomics,
spatial
genomics
and
reference
atlases
from
BRAIN
Initiative
to
study
middle
temporal
gyrus
cell
types
84
donors
with
varying
pathologies.
This
cohort
includes
33
male
51
female
donors,
an
average
age
at
time
death
88
years.
We
used
quantitative
neuropathology
place
along
a
pseudoprogression
score.
Pseudoprogression
analysis
revealed
two
phases:
early
phase
slow
increase
pathology,
presence
inflammatory
microglia,
reactive
astrocytes,
loss
somatostatin
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 12, 2024
Abstract
Developing
diagnostics
and
treatments
for
neurodegenerative
diseases
(NDs)
is
challenging
due
to
multifactorial
pathogenesis
that
progresses
gradually.
Advanced
in
vitro
systems
recapitulate
patient-like
pathophysiology
are
emerging
as
alternatives
conventional
animal-based
models.
In
this
review,
we
explore
the
interconnected
pathogenic
features
of
different
types
ND,
discuss
general
strategy
modelling
NDs
using
a
microfluidic
chip,
introduce
organoid-on-a-chip
next
advanced
relevant
model.
Lastly,
overview
how
these
models
being
applied
academic
industrial
drug
development.
The
integration
chips,
stem
cells,
biotechnological
devices
promises
provide
valuable
insights
biomedical
research
developing
diagnostic
therapeutic
solutions
NDs.
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Фев. 2, 2024
Abstract
Neuroinflammation
is
a
pathological
hallmark
of
Alzheimer’s
disease
(AD),
characterized
by
the
stimulation
resident
immune
cells
brain
and
penetration
peripheral
cells.
These
inflammatory
processes
facilitate
deposition
amyloid-beta
(Aβ)
plaques
abnormal
hyperphosphorylation
tau
protein.
Managing
neuroinflammation
to
restore
homeostasis
decrease
neuronal
damage
therapeutic
approach
for
AD.
One
way
achieve
this
through
exercise,
which
can
improve
function
protect
against
neuroinflammation,
oxidative
stress,
synaptic
dysfunction
in
AD
models.
The
neuroprotective
impact
exercise
regulated
various
molecular
factors
that
be
activated
same
as
administration
their
mimetics.
Recent
evidence
has
proven
some
mimetics
effective
alleviating
AD,
and,
additionally,
they
are
helpful
alternative
option
patients
who
unable
perform
regular
physical
manage
neurodegenerative
disorders.
This
review
focuses
on
current
state
knowledge
mimetics,
including
efficacy,
regulatory
mechanisms,
progress,
challenges,
limitations,
future
guidance
application
therapy.
Nutrition & Metabolism,
Год журнала:
2024,
Номер
21(1)
Опубликована: Март 19, 2024
Abstract
Context
Resveratrol
(RV),
a
natural
compound
found
in
grapes,
berries,
and
peanuts,
has
been
extensively
studied
for
its
potential
treating
Alzheimer’s
disease
(AD).
RV
shown
promise
inhibiting
the
formation
of
beta-amyloid
plaques
(Aβ)
neurofibrillary
tangles
(NFTs),
protecting
against
neuronal
damage
oxidative
stress,
reducing
inflammation,
promoting
neuroprotection,
improving
function
blood–brain
barrier
(BBB).
However,
conflicting
results
have
reported,
necessitating
comprehensive
umbrella
review
systematic
reviews
to
provide
an
unbiased
conclusion
on
therapeutic
effectiveness
AD.
Objective
The
objective
this
study
was
systematically
synthesize
evaluate
meta-analysis
investigating
role
AD
using
data
from
both
human
animal
studies.
Data
sources
extraction
Of
34
examining
association
between
that
were
collected,
six
included
based
specific
selection
criteria.
To
identify
pertinent
studies,
search
conducted
English-language
peer-reviewed
journals
without
any
restrictions
publication
date
until
October
15,
2023.
carried
out
across
multiple
databases,
including
Embase,
MEDLINE
(PubMed),
Cochrane
Library,
Web
Science,
Google
Scholar,
utilizing
appropriate
terms
relevant
research
field.
AMSTAR-2
ROBIS
tools
also
used
quality
risk
bias
reviews,
respectively.
Two
researchers
independently
extracted
analyzed
data,
resolving
discrepancies
through
consensus.
note,
adhered
PRIOR
checklist.
analysis
This
presented
robust
evidence
supporting
positive
impacts
AD,
irrespective
mechanisms
involved.
It
indeed
indicated
all
unanimously
concluded
consumption
can
be
effective
treatment
Conclusion
exhibits
promising
benefiting
individuals
with
various
mechanisms.
observed
enhance
cognitive
function,
reduce
Aβ
accumulation,
protect
BBB,
support
mitochondrial
facilitate
synaptic
plasticity,
stabilize
tau
proteins,
mitigate
neuroinflammation
commonly
associated
Graphical
abstract
