Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 6, 2023
Abstract
In
order
to
realize
the
effective
utilization
of
overproduced
Fructus
Mori
.
this
study,
different
fermentation
strains
(
Yeast,
Lactobacillus
bulgaricus
and
Monascus
)
were
used
as
starters
ferment
The
results
showed
that
maximum
polysaccharides
yield
could
reach
6.32%
under
optimal
conditions
(liquid-solid
ratio
28.58
mL/g,
inoculum
volume
4.93,
temperature
302.99
K
time
83.78
h).
antioxidant
studies,
had
good
scavenging
ability
on
four
free
radicals
(DPPH
radicals,
·OH
ABTS
superoxide
anions).
Moreover,
polysaccharide
strong
antibacterial
activity
against
6
tested
pathogens,
effect
was
Staphylococcus
aureus
(36.5±1.26
mm)>
Bacillus
subtilis
(33.5±1.12
Listeria
monocytogenes
(29.5±1.03
Escherichia
coli
(25.9±1.35
Salmonella
(21.5±1.06
Vibrio
parahaemolyticus
(15.8±1.16
mm)
with
concentration
40
mg/mL.
research
can
provide
a
certain
application
value
for
functional
development
polysaccharides.
Journal of Translational Internal Medicine,
Год журнала:
2024,
Номер
12(1), С. 22 - 34
Опубликована: Фев. 1, 2024
Abstract
Fibrosis
occurs
in
many
organs,
and
its
sustained
progress
can
lead
to
organ
destruction
malfunction.
Although
numerous
studies
on
fibrosis
have
been
carried
out,
underlying
mechanism
is
largely
unknown,
no
ideal
treatment
currently
available.
Ferroptosis
an
iron-dependent
process
of
programmed
cell
death
that
characterized
by
lipid
peroxidation.
In
the
past
decade,
a
growing
body
evidence
demonstrated
association
between
ferroptosis
fibrotic
diseases,
while
targeting
may
serve
as
potential
therapeutic
strategy.
This
review
highlights
recent
advances
crosstalk
fibrosis,
discusses
ferroptosis-targeted
approaches
against
are
being
explored.
Phytochemical Analysis,
Год журнала:
2024,
Номер
35(4), С. 860 - 872
Опубликована: Фев. 15, 2024
Abstract
Introduction
Liuweizhiji
Gegen‐Sangshen
(LGS)
oral
liquid
is
a
Chinese
patent
medicine
that
widely
used
for
the
prevention
and
treatment
of
alcoholic
liver
disease
in
clinical
practice.
However,
chemical
complexity
LGS
has
not
yet
been
investigated.
Objective
The
aim
this
study
was
to
rapidly
identify
constituents
establish
quality
control
method
based
on
fingerprint
quantitative
analysis.
Methodology
A
comprehensive
strategy
by
combining
qualitative
analysis
ultra‐performance
chromatography
tandem
quadrupole
time‐of‐flight
mass
spectrometry
(UPLC‐Q‐TOF‐MS)
high‐performance
with
diode
array
detection
(HPLC‐DAD).
Results
total
162
components
LGS,
including
91
flavonoids,
31
organic
acids,
20
phenolic
compounds,
were
identified
or
preliminarily
characterized
both
positive
negative
ion
modes
UPLC‐Q‐TOF‐MS
results.
Of
these,
37
confirmed
reference
standards.
In
analysis,
23
peaks
chosen
as
common
evaluate
similarity
different
batches
LGS.
Subsequently,
rapid
quantification
optimized
validated
simultaneous
determination
multiple
markers
successfully
analyze
samples.
Conclusion
proposed
HPLC‐DAD
fingerprinting
multi‐component
demonstrated
satisfactory
results
high
efficiency,
accuracy,
reliability.
This
can
be
overall
consistency
evaluation
medicines.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
Natural Product Communications,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Modern
dietary
habits
and
other
factors
have
led
to
a
global
rise
in
chronic
diseases,
posing
significant
threats
daily
life.
Among
the
most
valuable
fruits
worldwide,
mulberry
has
been
extensively
studied
for
its
diverse
health
benefits
economic
potential.
Mulberries
are
not
only
rich
nutrients
active
compounds
but
also
demonstrate
antioxidant,
hypolipidemic,
hypoglycemic,
hepatoprotective,
antibacterial,
anticancer
pharmacological
effects.
Despite
these
promising
attributes,
there
is
lack
of
systematic
evaluations
mulberry's
bioactive
substances
their
impacts.
Additionally,
increasing
focus
on
developing
derivatives
crucial
enhancing
value.
This
review,
complemented
by
bibliometric
analysis,
aggregates
relevant
information
from
databases
such
as
PubMed
Web
Science
explore
research
trends
hotspots.
Through
comprehensive
this
review
elucidates
nutritional
value
mulberry,
unique
mechanisms
preventing
treating
potential
applications
functional
foods
biomaterials.
The
latest
findings
summarized
provide
robust
scientific
foundation
future
research,
development,
utilization
derivatives,
thereby
expanding
deepening
promotion
disease
prevention.
Acta Biochimica et Biophysica Sinica,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 28, 2023
Acute
liver
failure
(ALF)
is
a
significant
global
issue
with
elevated
morbidity
and
mortality
rates.
There
an
urgent
pressing
need
for
secure
effective
treatments.
Ferroptosis,
novel
iron-dependent
regulation
of
cell
death,
plays
role
in
multiple
pathological
processes
associated
diseases,
including
ALF.
Several
studies
have
demonstrated
that
mesenchymal
stem
cells
(MSCs)
promising
therapeutic
potential
the
treatment
This
study
aims
to
investigate
positive
effects
MSCs
against
ferroptosis
ALF
model
explore
underlying
molecular
mechanisms
their
function.
Our
results
show
intravenously
injected
protect
mouse
models.
decrease
iron
deposition
mice
by
downregulating
hepcidin
level
upregulating
FPN1
level.
labelled
Dil
are
mainly
observed
hepatic
sinusoid
exhibit
colocalization
macrophage
marker
CD11b
fluorescence.
ELISA
demonstrates
high
IGF1
CCL
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
267, С. 115625 - 115625
Опубликована: Окт. 27, 2023
We
investigated
the
toxicological
mechanism
by
which
perfluorooctane
sulfonate
(PFOS)
induces
liver
injury
via
ferroptosis.
Primary
mouse
hepatocytes
were
treated
with
LD50
=
55
M
PFOS.
Their
cytotoxicity
was
detected
CCK-8
and
LDH
assays,
while
JC-1
staining
used
to
identify
their
mitochondrial
membrane
potential.
GSH-Px,
MDA,
SOD
levels
determined
using
kits,
Fe2
+
FerroOrange
probe
iron
ion
assay
kit.
The
DCFH-DA
examine
ROS
levels,
Western
blot
protein
expressions.
After
treatment
ferroptosis
inhibitor
YL939
BABTA,
ability
of
PFOS
induce
observed.
In
animal
experiments,
we
examined
function
degree
hepatic
mice
as
well
histopathological
changes.
could
hepatocyte
ferroptosis,
BABTA
inhibit
PFOS-induced
increase
in
tissue,
injury.
can
cause
mice,
is
its
mechanism.
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
41(13-15), С. 976 - 991
Опубликована: Июль 13, 2024
Numerous
disorders
are
linked
to
ferroptosis,
a
form
of
programmed
cell
death
triggered
by
lipid
peroxidation
accumulation
rather
than
apoptosis.
Inflammation
is
the
body's
defensive
response
stimuli
and
also
caused
inflammatory
chemicals
that
can
harm
body.
The
treatment
diseases
focusing
on
signaling
pathways
mechanisms
ferroptosis
has
emerged
as
new
area
worthy
extensive
research.
