The interplay between diet and the gut microbiome: implications for health and disease

Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 671 - 686

Опубликована: Июль 15, 2024

Язык: Английский

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The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 14, 2024

Abstract Context High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults is uncertain. Objective This study aimed synthesize findings on effects severity depressive symptoms depression. Data Sources PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web Science were systematically searched from database inception March 2023. The Preferred Reporting Items for Systematic Review Meta-Analyses guidelines recommendations followed. We included randomized controlled trials (RCTs) comparing outcomes after control conditions disorders or symptoms. Extraction Two authors extracted data independently. Sidik-Jonkman estimator, I2 metric, prediction interval used estimate between-study heterogeneity. To determine bias certainty evidence RCTs, we Collaboration’s Risk Bias 2 Grades Recommendation, Assessment, Development, Evaluation tools, respectively. Analysis In total, 1507 participants (mean age range: 22.0 years–53.3 years) initially 5 RCTs this review. Compared conditions, significantly young middle-aged major mild moderate (standardized mean difference: –0.53; 95% confidence interval: –0.90 –0.16; = 87.1%). ranged –1.86 0.81. overall was within range “some concerns” “high,” while low. Conclusion appear have substantial potential alleviating people experiencing However, establish robust recommendations, there remains need high-quality, large-scale, long-term RCTs. Registration PROSPERO registration no. CRD42022341895.

Язык: Английский

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

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Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a restoration strategy comprising diet that recapitulated key characteristics of non-industrialized dietary patterns (restore diet) bacterium rarely found in industrialized microbiomes (Limosilactobacillus reuteri) randomized controlled feeding trial healthy Canadian adults. The restore diet, despite reducing diversity, enhanced persistence L. reuteri strain from rural Papua New Guinea (PB-W1) redressed several features altered by industrialization. also beneficially microbiota-derived plasma metabolites implicated etiology Considerable cardiometabolic benefits were observed independently administration, which could be accurately predicted baseline diet-responsive features. findings suggest intervention targeted toward restoring can improve host-microbiome interactions likely underpin pathologies, guide recommendations development therapeutic nutritional strategies.

Язык: Английский

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Inhibitory effect of Dendrobium officinale polysaccharide on oxidative damage of glial cells in aging mice by regulating gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125787 - 125787

Опубликована: Июль 10, 2023

Язык: Английский

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A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Март 6, 2024

Alzheimer's disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using multi-omics approach in transgenic mouse model, the current study demonstrated efficacy of modified Mediterranean-ketogenic diet (MkD) on AD-related neurocognitive pathophysiology and underlying mechanisms related to gut-microbiome-brain axis. The findings revealed that MkD induces profound shifts gut microbiome community microbial metabolites. Most notably, promoted growth Lactobacillus population, resulting increased bacteria-derived lactate production. We discovered elevated levels microbiome- diet-derived metabolites serum as well, signaling their influence brain. Importantly, these changes upregulated specific receptors have neuroprotective effects induced alternations neuroinflammatory-associated pathway profiles hippocampus. Additionally, displayed strong favorable co-regulation relationship gut-brain integrity inflammatory markers, well neurobehavioral outcomes. underscore ameliorative neurological function communication via modulation microbiome-metabolome arrays.

Язык: Английский

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Ultra-Processed Foods: A Narrative Review of the Impact on the Human Gut Microbiome and Variations in Classification Methods

Nutrients, Год журнала: 2024, Номер 16(11), С. 1738 - 1738

Опубликована: Июнь 1, 2024

Ultra-processed foods (UPFs) are that industrially processed and often pre-packaged, convenient, energy-dense, nutrient-poor. UPFs widespread in the current Western diet their proposed contribution to non-communicable diseases such as obesity cardiovascular disease is supported by numerous studies. hypothesized affect body multiple ways, including inducing changes gut microbiome. This review summarizes available research on effect of We also usage NOVA food classification system randomized controlled trials observational studies how its implementation effects UPF research. Despite some differences methodology between studies, results associate consumption with a number negative health consequences. There attempts standardize system; however, reaching implementing consensus difficult. Future focusing mechanisms which body, through microbiome metabolome, will be essential refine our understanding human health.

Язык: Английский

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Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Nutrients, Год журнала: 2024, Номер 16(4), С. 549 - 549

Опубликована: Фев. 16, 2024

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in pathogenesis ASD. Research indicates abnormal composition gut microbiome potential involvement bacterial molecules neuroinflammation brain development disruptions. Concurrently, attention directed towards short-chain fatty acids (SCFAs) intestinal tightness. This comprehensive review emphasizes impact maternal microbiota changes on autism children, especially considering immune activation (MIA). The following paper evaluates birth route colonization child with bacteria first weeks life. Furthermore, it explores pro-inflammatory cytokines, such as IL-6 IL-17a mother’s obesity potentially environmental factors purpose this to advance our understanding ASD pathogenesis, while also searching for positive implications latest therapies, probiotics, prebiotics or fecal transplantation, targeting reducing inflammation. aims provide valuable insights that could instruct future studies treatments individuals affected

Язык: Английский

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Macronutrient balance determines the human gut microbiome eubiosis: insights from in vitro gastrointestinal digestion and fermentation of eight pulse species

Frontiers in Microbiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 30, 2025

The interactions between macronutrients, the human gut microbiome, and their metabolites (short-chain fatty acids) were comprehensively investigated via an in vitro digestion fermentation model subjected to eight pulse species. 16S rRNA sequencing taxonomic analysis of digesta fermented for up 24 h revealed increase relative abundance health-detrimental genera represented by Escherichia-Shigella kidney bean, soybean, cowpea, chickpea, black bean samples. In contrast, health-positive genera, including Bacteroides , Eubacterium Akkermansia was elevated red mung Heunguseul. At same time, proportion pathogenic decreased. Concurrently, these three species exhibited microbial diversity as evidenced calculation α -diversity (Shannon index) β (Bray-Curtis distance). Despite lower nutrient contents pulses, carbohydrates, amino acids, network that possess complex positive or negative correlations with a variety bacteria, well metabolites. These more pronounced Heunguseul than other pulses. It postulated overall potential nourish environments due balance nutritional components. linear regression demonstrated there association carbohydrate acid Shannon indices. Furthermore, ratio carbohydrates acids displayed increase. showed weak correlation. is noteworthy diet comprising foods balanced profile supports growth beneficial microbes, thereby promoting eubiosis. Consistent work on different ingredients essential precise insight into interplay food microbiome dietary patterns.

Язык: Английский

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Dietary index for gut microbiota is associated with stroke among US adults

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The dietary index for gut microbiota was inversely associated with stroke prevalence, particularly in adults aged 30 years and above.

Язык: Английский

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