Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 947 - 947
Опубликована: Июль 17, 2024
Acne vulgaris, a prevalent skin condition, arises from an imbalance in flora, fostering bacterial overgrowth. Addressing this issue, clindamycin molecularly imprinted polymeric nanoparticles (Clin-MIP) loaded onto polyurethane nanofiber scaffolds were developed for acne treatment. Clin-MIP was synthesized via precipitation polymerization using methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), and azoisobutyronitrile (AIBN) as functional monomers, crosslinkers, free-radical initiators, respectively. MIP characterization utilized Fourier-transform infrared spectroscopy (FTIR) transmission electron microscopy (TEM) before being incorporated into nanofibers through electrospinning. Further analysis involved FTIR, scanning (SEM), vitro release studies, ex vivo study. showed strong antibacterial activity against S. aureus, with inhibitory concentration (MIC) minimum bactericidal (MBC) values of 0.39 6.25 μg/mL, It significantly dropped the count 1 × 108 to 39 101 CFU/mL has within 180 min incubation vitro. The pharmacodynamic histopathology studies revealed significant decrease infected animal inflammation, epidermal hypertrophy, congestion upon treatment reduced pro-inflammatory cytokines (NLRP3, TNF-α, IL-1β, IL-6) conducive healing. Consequently, recently created nanofibrous scaffold. This innovative approach offers insight creating materials several uses treating infectious wounds caused by acne.
Язык: Английский
Процитировано
6Antibody mimics for precise identification of proteins based on molecularly imprinted polymers: Developments and prospects
Chemical Engineering Journal, Год журнала: 2023, Номер 480, С. 148115 - 148115
Опубликована: Дек. 17, 2023
Язык: Английский
Процитировано
15Biomimetic/Bioderived Nanoengineered Interfaces for Biosensor Applications: A Review
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(17), С. 19854 - 19875
Опубликована: Авг. 23, 2024
Nature inspires technological innovation through unique micronanostructured surfaces, such as fish fins, lotus leaves, butterfly wings, rose petals, a bird's spongy bone, etc. These structures exhibit capabilities beyond conventional engineering, making biomimetics key focus of scientific research. Integrating nanotechnology, biology, and bioengineering has significantly propelled the development nanomaterials with distinct functions properties. This interdisciplinary synergy extensively advanced biomimetic nanomaterials. review highlights nanomaterials, an emphasis on state-of-the-art sensing devices. In addition to this, it furnishes extensive compendium investigations into synthesis fabrication metal–organic frameworks (MOFs), molecularly imprinted polymers (MIPs), carbon-based (graphene, carbon nanotubes), gold nanoparticles (AuNPs), for biosensor development. We have focused their applications in disease diagnostics within healthcare while also addressing role environmental monitoring agriculture. comprehensive aims impart insightful understanding complexities associated these technologies concludes appraisal current challenges future developments.
Язык: Английский
Процитировано
4An intriguing future is approaching: Artificial intelligence meets molecularly imprinted polymers
Journal of Pharmaceutical and Biomedical Analysis Open, Год журнала: 2024, Номер 4, С. 100041 - 100041
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
4Tailoring Design of Microneedles for Drug Delivery and Biosensing
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.
Язык: Английский
Процитировано
0Understanding Adsorption: Theories, Techniques, and Applications
IntechOpen eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
The chapter topic “Understanding Adsorption: Theories, Techniques, and Applications” will provide a comprehensive exploration of the fundamental theories, experimental techniques, practical applications adsorption processes. It begin by discussing foundational theories that explain behaviour, including physisorption chemisorption, their underlying molecular interactions. Key models, such as Langmuir, Freundlich BET isotherms, be reviewed to offer insights into dynamics, capacity surface also cover various techniques used characterise adsorption, gravimetric methods, gas analysis calorimetry, which help determine properties adsorbents adsorbates. Furthermore, examine real-world in diverse fields, environmental engineering for water air purification, separation, catalysis energy storage systems. potential advanced adsorbent materials, porous materials nanostructures, discussed light emerging challenges technological advancements. This aims equip readers with both theoretical knowledge wide-ranging
Язык: Английский
Процитировано
0Beyond Single-Analyte Detection: Advancing Molecularly Imprinted Polymers for Simultaneous Multi-Target Sensing
TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер 185, С. 118177 - 118177
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
0The Importance and Use of Polydopamine in Molecularly Imprinted Polymer-Based Electrochemical Sensor Design
Critical Reviews in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 11, 2025
Due to their natural biocompatibility, cost-effectiveness, and strong interfacial adhesion, biopolymers have highly favorable properties for electrochemical biosensors. this endogenous catecholamine's versatile chemistry, dopamine's oxidation self-polymerization recently attracted considerable interest. Polydopamine (PDA)'s application surface deposition, molecular imprinting, electrochemistry is especially noteworthy. This review aims propose the role of PDA in quantitative applications, evaluate analytical performance, cost, reproducibility, versatility methods developed, standard (bio)analytical platforms. First, parameters that influence polymerization dopamine are discussed. Then, different functionalities its recent applications biosensing purposes reviewed build bioanalytical The discussion concludes with emerging PDA-integrated biosensor Finally, future perspectives improved use
Язык: Английский
Процитировано
0Clinical Impact of Exosome Chemistry in Cancer
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Язык: Английский
Процитировано
0Theranostic Advances and the Role of Molecular Imprinting in Disease Management
iScience, Год журнала: 2025, Номер 28(4), С. 112186 - 112186
Опубликована: Март 10, 2025
Molecular imprinting has become an effective technology in the realm of diagnosing diseases, providing unparalleled specificity and sensitivity. This method is a promising trend current medical research. review examines utilization molecularly imprinted polymers (MIPs) theranostic that integrates diagnostic functionalities for personalized medicine. The present work briefly discusses fundamental concepts molecular how it evolved into versatile platform. Subsequently, MIPs advancement biosensors focused, specifically emphasizing their contribution to detection diagnosis diseases. therapeutic potential MIPs, focusing on targeted drug delivery controlled release systems integration platforms explored through case studies, showcasing technology's ability simultaneously diagnose treat Finally, we address challenges facing discuss future perspectives, this revolutionize next generation.
Язык: Английский
Процитировано
0