Two decades of ceria nanoparticle research: structure, properties and emerging applications

Materials Horizons, Год журнала: 2024, Номер 11(14), С. 3213 - 3266

Опубликована: Янв. 1, 2024

Cerium oxide nanoparticles (CeNPs) are versatile materials with unique and unusual properties that vary depending on their surface chemistry, size, shape, coating, oxidation states, crystallinity, dopant, structural defects. This review encompasses advances made over the past twenty years in development of CeNPs ceria-based nanostructures, determinants affecting activity, translation these distinct features into applications. The two states nanosized (Ce

Язык: Английский

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Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 15, 2024

With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.

Язык: Английский

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Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 5, 2024

Abstract Background Osteoporosis is characterized by an imbalance in bone homeostasis, resulting the excessive dissolution of minerals due to acidified microenvironment mediated overactive osteoclasts. Oroxylin A (ORO), a natural flavonoid, has shown potential reversing osteoporosis inhibiting osteoclast-mediated resorption. The limited water solubility and lack targeting specificity hinder effective accumulation within pathological environment osteoporosis. Results Osteoclasts’ microenvironment-responsive nanoparticles are prepared incorporating with amorphous calcium carbonate (ACC) coated glutamic acid hexapeptide-modified phospholipids, aiming at reinforcing drug delivery efficiency as well therapeutic effect. obtained smart nanoparticles, coined OAPLG, could instantly neutralize release extracellular combination ACC synergistically inhibits osteoclast formation activity, leading significant reversal systemic loss ovariectomized mice model. Conclusion work highlights intelligent nanoplatform based on for spatiotemporally controlled lipophilic drugs, illustrates prominent promise against

Язык: Английский

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Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair

Bone, Год журнала: 2024, Номер 188, С. 117220 - 117220

Опубликована: Авг. 5, 2024

Язык: Английский

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Immunomodulatory nanomedicine for osteoporosis: Current practices and emerging prospects

Acta Biomaterialia, Год журнала: 2024, Номер 179, С. 13 - 35

Опубликована: Март 16, 2024

Язык: Английский

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Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Journal of Biological Engineering, Год журнала: 2024, Номер 18(1)

Опубликована: Апрель 22, 2024

Abstract There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of regeneration involves the transformation mesenchymal stromal cells into osteoblasts subsequent mineralization extracellular matrix, making up complex mechanism osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known its ability to stimulate formation, has been found encourage improve mineralization. Several studies demonstrated effects icariin, which can be attributed hormone-like function. It induce expression BMP-2 BMP-4 mRNAs significantly upregulate Osx at low doses. Additionally, icariin promotes formation by stimulating pre-osteoblastic genes like Osx, RUNX2, collagen type I. However, needs delivered perform promising functions. Encapsulating within nanoplatforms holds significant promise promoting through a range intricate biological effects. When encapsulated nanofibers or nanoparticles, exerts directly cellular level. Recalling inflammation factor influencing regeneration, icariin's anti-inflammatory harnessed amplified when nanoplatforms. Also, while cell adhesion migration are pivotal stages tissue icariin-loaded contribute these processes providing supportive matrix attachment movement. This review comprehensively discusses used osteogenesis, further presenting where field go before clinically.

Язык: Английский

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Exploring the link between nephrolithiasis and osteoporosis: implications for clinical management and treatment advancements

International Urology and Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

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Evolution of Metals and Alloys in Orthopedics with Their Relevance in Osteoporosis

Indian Journal of Orthopaedics, Год журнала: 2025, Номер 59(3), С. 271 - 279

Опубликована: Март 1, 2025

Язык: Английский

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Study on the Pathological Mechanisms and Impact of Osteoporotic Fractures under the Influence of Aging

Aging Research, Год журнала: 2025, Номер 12(03), С. 217 - 222

Опубликована: Янв. 1, 2025

Язык: Английский

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An update on the pharmacotherapy of osteoporosis

Expert Opinion on Pharmacotherapy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Osteoporosis is a chronic metabolic bone disease characterized by progressive loss and structural deterioration, increasing fracture risk morbidity. As the global population ages, its incidence rising, underscoring urgent need for more effective prevention treatment strategies. This review synthesizes latest evidence guidelines from leading international societies, establishing contemporary framework osteoporosis pharmacotherapy. It emphasizes best practices explores future directions in optimization prevention. To optimize outcomes, enhancing early detection, refining strategies, prioritizing patient-centered care are essential. Improving diagnosis through increased use of mineral density (BMD) assessments identifying secondary causes critical steps to addressing underdiagnosis, particularly men. Pharmacotherapies play vital role management; while bisphosphonates serve as cost-effective first-line treatment, Denosumab anabolic agents like Teriparatide Romosozumab essential alternatives high-risk patients. Future management emphasize advancing strategies novel drug targets innovative delivery systems, alongside personalized medicine approaches considering individual genetic comorbidity profiles. Enhanced adherence further research into combination therapies monitoring tools crucial improving ultimately reducing fragility burden worldwide.

Язык: Английский

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