Опубликована: Дек. 27, 2024
Язык: Английский
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(8), С. 2381 - 2381
Опубликована: Апрель 19, 2024
Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims present the role that elements play central nervous system. Moreover, we reviewed mechanisms involved their neurotoxicity. Low zinc concentrations, well high levels of copper, manganese, iron, activate signalling pathways inflammatory, oxidative nitrosative stress response. Neurodegeneration occurs due association between metals proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In disease, low Zn suppress neurotoxicity induced β-amyloid through selective precipitation aggregation intermediates. High iron manganese cause intracellular α-synuclein, results synaptic dysfunction axonal transport disruption. caused accumulation Fe midbrain dopaminergic nucleus, pathogenesis multiple sclerosis derives from deficiency, leading an imbalance T functions. Aluminium disturbs homeostasis other a rise production oxygen reactive forms, leads cellular Selenium, with plays distinct process ferroptosis. Outlining influence have on oxidoreduction processes crucial recognising pathophysiology diseases may provide possible new methods for both avoidance therapy.
Язык: Английский
Процитировано
18
Frontiers in Pharmacology, Год журнала: 2024, Номер 14
Опубликована: Янв. 12, 2024
Alzheimer's disease (AD), an age-associated neurodegenerative disorder, currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds promising potential in AD treatment, exemplified by Danggui Shaoyao San (DSS), a TCM formulation. The precise therapeutic mechanisms of DSS remain to be fully elucidated. This study aims uncover the efficacy and underlying AD, employing integrative approach encompassing gut microbiota metabolomic analyses.
Язык: Английский
Процитировано
13
Glia, Год журнала: 2025, Номер 73(3), С. 519 - 538
Опубликована: Янв. 6, 2025
Human genetics studies lent firm evidence that microglia are key to Alzheimer's disease (AD) pathogenesis over a decade ago following the identification of AD-associated genes expressed in microglia-specific manner. However, while alterations microglial morphology and gene expression observed human postmortem brain tissue, mechanisms by which drive contribute AD pathology remain ill-defined. Numerous mouse models have been developed facilitate disambiguation biological underlying AD, incorporating amyloidosis, phosphorylated tau, or both. Over time, use multiple technologies including bulk tissue single cell transcriptomics, epigenomics, spatial proteomics, lipidomics, metabolomics shed light on heterogeneity phenotypes molecular patterns altered models. Each these 'omics provide unique information insight. Here, we review literature approaches findings methods synthesis knowledge generated applying AD.
Язык: Английский
Процитировано
1
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Янв. 16, 2024
Background Currently, the prevalence of Alzheimer’s disease (AD) is progressively rising, particularly in developed nations. There an escalating focus on onset and progression AD. A mounting body research indicates that epigenetics significantly contributes to AD holds substantial promise as a novel therapeutic target for its treatment. Objective The objective this article present areas interest, comprehend contextual framework subject research, investigate prospective direction future development. Methods ln Web Science Core Collection (WOSCC), we searched documents by specific terms their corresponding free words. VOSviewer, CiteSpace Scimago Graphica were used perform statistical analysis measurement metrics such number published papers, national cooperative networks, publishing countries, institutions, authors, co-cited journals, keywords, visualize networks related content elements. Results We selected 1,530 articles from WOSCC January 2013 June 2023 about Based visual analysis, could get China United States countries with most field. Bennett DA was contributed prestigious scientist. top 3 cited journals Journal Disease, Neurobiology Aging Molecular Neurobiology. According keywords frequency citations, ncRNAs, transcription factor, genome, histone modification, blood DNA methylation, acetylation, biomarkers hot directions today. Conclusion bibliometric epigenetic promising direction, had potential be targets.
Язык: Английский
Процитировано
5
Pharmacological Reports, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 6, 2025
The goal of this review is to highlight the role second-hand smoke (SHS) or environmental tobacco (ETS) and e-cigarette (EC) vapors on brain integrity function during development adulthood, including how it relates increasing risk for age-related neurodegenerative disorders. A systematic literature effect SHS ETS revealed a total 284 372 publications 312 publications, respectively. After taking into account duplicate focused policy, surveys other organs than brain, there are limited studies effects SHS, EC structure function. In review, we examine major constituents in their health, mechanisms by which alters function, behavioral cognitive performance. We hope that will encourage investigators explore further short-as well long-term vapor exposure developing adult better understand its neurodevelopmental disorders diseases ultimately develop therapeutic modalities reduce even prevent short- detrimental health.
Язык: Английский
Процитировано
0
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 16, 2025
Язык: Английский
Процитировано
0
Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 141, С. 112940 - 112940
Опубликована: Авг. 17, 2024
Язык: Английский
Процитировано
3
Molecular Neurobiology, Год журнала: 2024, Номер 62(4), С. 4499 - 4519
Опубликована: Окт. 26, 2024
Язык: Английский
Процитировано
3