Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2381 - 2381

Published: April 19, 2024

Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims present the role that elements play central nervous system. Moreover, we reviewed mechanisms involved their neurotoxicity. Low zinc concentrations, well high levels of copper, manganese, iron, activate signalling pathways inflammatory, oxidative nitrosative stress response. Neurodegeneration occurs due association between metals proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In disease, low Zn suppress neurotoxicity induced β-amyloid through selective precipitation aggregation intermediates. High iron manganese cause intracellular α-synuclein, results synaptic dysfunction axonal transport disruption. caused accumulation Fe midbrain dopaminergic nucleus, pathogenesis multiple sclerosis derives from deficiency, leading an imbalance T functions. Aluminium disturbs homeostasis other a rise production oxygen reactive forms, leads cellular Selenium, with plays distinct process ferroptosis. Outlining influence have on oxidoreduction processes crucial recognising pathophysiology diseases may provide possible new methods for both avoidance therapy.

Language: Английский

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Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer’s disease-related pathology

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 12, 2024

Alzheimer's disease (AD), an age-associated neurodegenerative disorder, currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds promising potential in AD treatment, exemplified by Danggui Shaoyao San (DSS), a TCM formulation. The precise therapeutic mechanisms of DSS remain to be fully elucidated. This study aims uncover the efficacy and underlying AD, employing integrative approach encompassing gut microbiota metabolomic analyses.

Language: Английский

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Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” Studies

Glia, Journal Year: 2025, Volume and Issue: 73(3), P. 519 - 538

Published: Jan. 6, 2025

Human genetics studies lent firm evidence that microglia are key to Alzheimer's disease (AD) pathogenesis over a decade ago following the identification of AD-associated genes expressed in microglia-specific manner. However, while alterations microglial morphology and gene expression observed human postmortem brain tissue, mechanisms by which drive contribute AD pathology remain ill-defined. Numerous mouse models have been developed facilitate disambiguation biological underlying AD, incorporating amyloidosis, phosphorylated tau, or both. Over time, use multiple technologies including bulk tissue single cell transcriptomics, epigenomics, spatial proteomics, lipidomics, metabolomics shed light on heterogeneity phenotypes molecular patterns altered models. Each these 'omics provide unique information insight. Here, we review literature approaches findings methods synthesis knowledge generated applying AD.

Language: Английский

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A bibliometric and visual analysis of epigenetic research publications for Alzheimer’s disease (2013–2023)

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Jan. 16, 2024

Background Currently, the prevalence of Alzheimer’s disease (AD) is progressively rising, particularly in developed nations. There an escalating focus on onset and progression AD. A mounting body research indicates that epigenetics significantly contributes to AD holds substantial promise as a novel therapeutic target for its treatment. Objective The objective this article present areas interest, comprehend contextual framework subject research, investigate prospective direction future development. Methods ln Web Science Core Collection (WOSCC), we searched documents by specific terms their corresponding free words. VOSviewer, CiteSpace Scimago Graphica were used perform statistical analysis measurement metrics such number published papers, national cooperative networks, publishing countries, institutions, authors, co-cited journals, keywords, visualize networks related content elements. Results We selected 1,530 articles from WOSCC January 2013 June 2023 about Based visual analysis, could get China United States countries with most field. Bennett DA was contributed prestigious scientist. top 3 cited journals Journal Disease, Neurobiology Aging Molecular Neurobiology. According keywords frequency citations, ncRNAs, transcription factor, genome, histone modification, blood DNA methylation, acetylation, biomarkers hot directions today. Conclusion bibliometric epigenetic promising direction, had potential be targets.

Language: Английский

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Intranasal amyloid model of Alzheimer’s disease - potential opportunities and challenges

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 6, 2025

The goal of this review is to highlight the role second-hand smoke (SHS) or environmental tobacco (ETS) and e-cigarette (EC) vapors on brain integrity function during development adulthood, including how it relates increasing risk for age-related neurodegenerative disorders. A systematic literature effect SHS ETS revealed a total 284 372 publications 312 publications, respectively. After taking into account duplicate focused policy, surveys other organs than brain, there are limited studies effects SHS, EC structure function. In review, we examine major constituents in their health, mechanisms by which alters function, behavioral cognitive performance. We hope that will encourage investigators explore further short-as well long-term vapor exposure developing adult better understand its neurodevelopmental disorders diseases ultimately develop therapeutic modalities reduce even prevent short- detrimental health.

Language: Английский

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Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Language: Английский

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Targeting UAF1 Alleviate Neurotoxicity by Inhibiting APP/NLRP3 Axis-Mediated Pyroptosis and Apoptosis

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: April 1, 2025

Language: Английский

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Unveiling the role of astrogliosis in Alzheimer’s disease Pathology: Insights into mechanisms and therapeutic approaches

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112940 - 112940

Published: Aug. 17, 2024

Language: Английский

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Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4499 - 4519

Published: Oct. 26, 2024

Language: Английский

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