Intelligent reprogramming of wheat for enhancement of fungal and nematode disease resistance using advanced molecular techniques DOI Creative Commons

Muhammad Jabran,

Muhammad Amjad Ali, Adil Zahoor

и другие.

Frontiers in Plant Science, Год журнала: 2023, Номер 14

Опубликована: Май 10, 2023

Wheat ( Triticum aestivum L.) diseases are major factors responsible for substantial yield losses worldwide, which affect global food security. For a long time, plant breeders have been struggling to improve wheat resistance against by selection and conventional breeding techniques. Therefore, this review was conducted shed light on various gaps in the available literature reveal most promising criteria disease wheat. However, novel techniques molecular past few decades very fruitful developing broad-spectrum other important traits Many types of markers such as SCAR, RAPD, SSR, SSLP, RFLP, SNP, DArT, etc., reported pathogens. This article summarizes insightful involved improvement through diverse programs. Moreover, highlights applications marker assisted (MAS), quantitative trait loci (QTL), genome wide association studies (GWAS) CRISPR/Cas-9 system diseases. We also reviewed all mapped QTLs bunts, rusts, smuts, nematode Furthermore, we proposed how GWAS can assist future genetic If these approaches used successfully future, they be significant step toward expanding production crops.

Язык: Английский

Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges DOI Creative Commons
Misganaw Asmamaw Mengstie

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Май 12, 2022

The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its accompanying protein (Cas9) are now the most effective, efficient, precise genome editing techniques. Two essential components of CRISPR/Cas9 system guide RNA (gRNA) CRISPR-associated proteins. Choosing implementing safe effective delivery systems in therapeutic application has proven to be a significant problem. For vivo delivery, viral vectors natural specialists. Due their higher effectiveness than other methods, such as adenoviral (AdVs), adeno-associated viruses (AAVs), lentivirus (LVs) commonly employed methods. This review thoroughly examined recent achievements using variety means well benefits limitations each vector. Future thoughts for overcoming current restrictions adapting technology also discussed.

Язык: Английский

Процитировано

81

Consumer acceptance of new food trends resulting from the fourth industrial revolution technologies: A narrative review of literature and future perspectives DOI Creative Commons
Abdo Hassoun, Janna Cropotova, Monica Trif

и другие.

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Авг. 10, 2022

The growing consumer awareness of climate change and the resulting food sustainability issues have led to an increasing adoption several emerging trends. Some these trends been strengthened by emergence fourth industrial revolution (or Industry 4.0), its innovations technologies that fundamentally reshaped transformed current strategies prospects for production consumption patterns. In this review a general overview revolutions through perspective will be provided. Then, knowledge base regarding acceptance eight traditional animal-proteins alternatives (e.g., plant-based foods insects) more recent cell-cultured meat 3D-printed foods) updated. A special focus given impact digital other 4.0 on shift toward greener, healthier, sustainable diets. Emerging promising potential promote nutritious animal-based products. This literature narrative showed are largest portion alternative proteins but intensive research is being done with sources (notably insects animal products). Recent technological advances likely significant roles in enhancing sensory nutritional properties, improving perception foods. Thus, new predicted continue growing, although effort should made make products convenient, nutritious, affordable, market them consumers positively emphasizing their safety benefits.

Язык: Английский

Процитировано

76

Recent Advances for Drought Stress Tolerance in Maize (Zea mays L.): Present Status and Future Prospects DOI Creative Commons
Seema Sheoran,

Yashmeet Kaur,

Sushil Kumar

и другие.

Frontiers in Plant Science, Год журнала: 2022, Номер 13

Опубликована: Май 30, 2022

Drought stress has severely hampered maize production, affecting the livelihood and economics of millions people worldwide. In future, as a result climate change, unpredictable weather events will become more frequent hence implementation adaptive strategies be inevitable. Through utilizing different genetic breeding approaches, efforts are in progress to develop drought tolerance maize. The recent approaches genomics-assisted breeding, transcriptomics, proteomics, transgenics, genome editing have fast-tracked enhancement for under laboratory field conditions. could considerably improved by combining omics technologies with novel methods high-throughput phenotyping (HTP). This review focuses on responses against drought, well system biology applied better understand mechanisms development drought-tolerant cultivars. Researchers must disentangle molecular physiological bases features order increase yield. Therefore, integrated investments field-based HTP, biology, sophisticated methodologies expected help stabilize production face change.

Язык: Английский

Процитировано

71

Artificial Intelligence in Regenerative Medicine: Applications and Implications DOI Creative Commons
Hamed Nosrati, Masoud Nosrati

Biomimetics, Год журнала: 2023, Номер 8(5), С. 442 - 442

Опубликована: Сен. 20, 2023

The field of regenerative medicine is constantly advancing and aims to repair, regenerate, or substitute impaired unhealthy tissues organs using cutting-edge approaches such as stem cell-based therapies, gene therapy, tissue engineering. Nevertheless, incorporating artificial intelligence (AI) technologies has opened new doors for research in this field. AI refers the ability machines perform tasks that typically require human ways learning patterns data applying without being explicitly programmed. potential improve accelerate various aspects development, particularly, although not exclusively, when complex are involved. This review paper provides an overview context medicine, discusses its applications with a focus on personalized highlights challenges opportunities

Язык: Английский

Процитировано

59

Steering self-organisation through confinement DOI Creative Commons
N. A. M. Araújo, Liesbeth M. C. Janssen, Thomas Barois

и другие.

Soft Matter, Год журнала: 2023, Номер 19(9), С. 1695 - 1704

Опубликована: Янв. 1, 2023

Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns from interaction smaller individual units. Examples are found across many scales in very different systems scientific disciplines, physics, materials science robotics to biology, geophysics astronomy. Recent research has highlighted how self-organisation can be both mediated controlled by confinement. Confinement occurs through interactions with boundaries, function as either a catalyst or inhibitor self-organisation. It then become means actively steer suppression collective phenomena space time. Here, provide common framework for future research, we examine role confinement identify overarching challenges disciplines that need addressed harness its full technological potential. This will not only accelerate generation deeper understanding but also trigger development innovative strategies it confinement, impact, e.g., on design smarter materials, tissue engineering biomedicine crowd management.

Язык: Английский

Процитировано

42

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine DOI Creative Commons
Mohadeseh Khoshandam, Hossein Soltaninejad, Marziyeh Mousazadeh

и другие.

Genes & Diseases, Год журнала: 2023, Номер 11(1), С. 268 - 282

Опубликована: Март 25, 2023

CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced short palindromic repeats) as a bacterial immune system and plays tool. Due to higher specificity efficiency compared other approaches, it has been broadly investigated treat hereditary acquired illnesses, including cancers, hemolytic diseases, immunodeficiency disorders, cardiovascular visual maladies, neurodegenerative conditions, few X-linked disorders. used cancers through variety stable techniques. Here, clinical trials in various illnesses are described. its high precision efficiency, strategies may gene-related by deleting, inserting, modifying, blocking expression specific genes. The most challenging barrier vivo use like off-target effects will be discussed. transfection vehicles CRISPR/Cas9, viral vectors (such Adeno-associated virus (AAV)), development non-viral also considered.

Язык: Английский

Процитировано

42

Gene therapy for CNS disorders: modalities, delivery and translational challenges DOI
Jingjing Gao,

Swetharajan Gunasekar,

Ziting Xia

и другие.

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(8), С. 553 - 572

Опубликована: Июнь 19, 2024

Язык: Английский

Процитировано

19

Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors DOI
Fabian P. Suchy, Daiki Karigane, Yusuke Nakauchi

и другие.

Nature Biotechnology, Год журнала: 2024, Номер unknown

Опубликована: Апрель 8, 2024

Язык: Английский

Процитировано

17

Application of Gene Editing for Climate Change in Agriculture DOI Creative Commons
Nicholas G. Karavolias,

Wilson Horner,

Modesta Abugu

и другие.

Frontiers in Sustainable Food Systems, Год журнала: 2021, Номер 5

Опубликована: Сен. 7, 2021

Climate change imposes a severe threat to agricultural systems, food security, and human nutrition. Meanwhile, efforts in crop livestock gene editing have been undertaken improve performance across range of traits. Many the targeted phenotypes include attributes that could be beneficial for climate adaptation. Here, we present examples emerging applications research initiatives are aimed at improvement crops response change, discuss technical limitations opportunities therein. While only few translated production thus far, numerous studies settings demonstrated potential potent address near future.

Язык: Английский

Процитировано

100

Nucleic acid delivery with extracellular vesicles DOI
Michaela Schulz‐Siegmund, Achim Aigner

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 173, С. 89 - 111

Опубликована: Март 20, 2021

Язык: Английский

Процитировано

76