Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues

Journal of Controlled Release, Год журнала: 1985, Номер 2, С. 257 - 275

Опубликована: Ноя. 1, 1985

Язык: Английский

---

Biodegradable polymers as biomaterials

Journal of Biomaterials Science Polymer Edition, Год журнала: 1995, Номер 6(9), С. 775 - 795

Опубликована: Янв. 1, 1995

—Biomaterials are used in prostheses and medical devices for different purposes. Polymers the most diverse class of biomaterials. All biomaterials must meet certain criteria regulatory requirements before they can be qualified use applications. Biocompatibility is one important requirements. Both nondegradable polymers designed to degrade vivo a controlled manner over predetermined time. The main mechanism degradation 'hydrolytic degradation', which enzymes may also play role (i.e. 'enzymatic degradation'). natural e.g., collagen, synthetic poly(α-hydroxy) acids, biodegradable biomedical Many current processing techniques need improved order produce with better performance biological media. An trend related research development synthesis novel polymers, would exhibit biocompatibility, bioresponsive.

Язык: Английский

---

Applications of carrier erythrocytes in delivery of biopharmaceuticals

Journal of Controlled Release, Год журнала: 2006, Номер 118(2), С. 145 - 160

Опубликована: Дек. 16, 2006

Язык: Английский

---

Inhibition of serum angiotensin-converting enzyme in rabbits after intravenous administration of enalaprilat-loaded intact erythrocytes

Journal of Pharmacy and Pharmacology, Год журнала: 2001, Номер 53(9), С. 1281 - 1286

Опубликована: Сен. 1, 2001

Encapsulation of drugs in intact erythrocytes, because the profound characteristics these natural microspheres, has gained considerable attention recent years. In this study, inhibition time courses serum angiotensin-converting enzyme (ACE) activity after intravenous administration enalaprilat encapsulated erythrocytes was evaluated and compared with free drug, a rabbit model. Three groups animals each received drug-loaded or sham-encapsulated erythrocytes. Serum ACE determined case using synthetic substrate hippuryl-histidyl-leucine quantitation hippuric acid released by developed validated HPLC method. The profiles three showed that drug inhibited more slowly, efficiently, over considerably longer reproducible manner, than We conclude can serve as efficacious slow-release carriers for circulation.

Язык: Английский

---

Long-Term Controlled Navel Administration of Testosterone

Journal of Pharmaceutical Sciences, Год журнала: 1984, Номер 73(8), С. 1064 - 1067

Опубликована: Авг. 1, 1984

Язык: Английский

---

Magnetically Driven Bio reactors as new Tools in Drug Delivery

Journal of Bioanalysis & Biomedicine, Год журнала: 2012, Номер s5

Опубликована: Янв. 1, 2012

The pharmacological properties of many drugs can be improved by drug delivery systems able to drive therapeutic agents target regions.The use carriers, in fact, may reduce possible cytotoxic effects and increase their bioavailability at the site action, thus improving efficacy safety treatments.Therefore, we have developed an erythrocyte-based system (erythro-magneto-HA virosome), which has potential magnetically guided specific sites fuse with cells.These engineered erythrocytes demonstrated previous work a very high vitro capability release anticancer directly inside cells.Because erythro-magneto-HA virosomes (EMHVs) proved promising decided investigate more details effectiveness this system.We evaluated ability EMHVs specifically localized vivo desired means external magnetic field protect such as 5-Aza-2'-deoxycytidine from degradation.Additionally assessed act bioreactors convert pro-drug into active drug.Finally, studied interaction host immune system.The short half-life when systemically injected needs phosphorylated become drug.We found that it is protected degradation transformed its form becoming readily available for uptake targeted cells.Moreover, observed used didn't cause either cell-mediated or humoral response mice having same haplotype donors.These findings suggest are safe useful offer numerous advantages several clinical applications.

Язык: Английский

---

Diabetes Mellitus and Closed-Loop Insulin Delivery

Biotechnology and Genetic Engineering Reviews, Год журнала: 2000, Номер 17(1), С. 455 - 496

Опубликована: Авг. 1, 2000

(2000). Diabetes Mellitus and Closed-Loop Insulin Delivery. Biotechnology Genetic Engineering Reviews: Vol. 17, No. 1, pp. 455-496.

Язык: Английский

---

None

Asian Journal of Pharmaceutics, Год журнала: 2016, Номер 10(4)

Опубликована: Ноя. 13, 2016

Nowadays conventional dosage forms of drugs are rapidly being replaced by the new and novel drug delivery systems. Among, these controlled release/sustained release have become extremely popular in modern therapeutics. In last few years, sustained injections developed. At targeted site, showed prolong effect drug. Decrease side effects, lesser frequency dose, maximum dose-efficacy relationship, improved patient compliance benefits received drugs. To systemic circulation, parenteral can achieve easy access with rapid absorption. It is always advantageous to levels within therapeutically effective concentration range for obtaining better treatment. With arrival carriers, research technologies has huge boost up. So, many injectable products regulatory approval launched pharmaceutical market. present review, efforts were put forth on rationale most recent progress done development formulation The review focused current long-acting preparations special attention marketed products.

Язык: Английский

---

Resealed Erythrocytes: A Comprehensive Review

Scholars Academic Journal of Pharmacy, Год журнала: 2024, Номер 13(06), С. 261 - 270

Опубликована: Июнь 5, 2024

Among the many carriers that are turned down for administering medications to various body nerves, cellular must meet a number of requirements clinical use, most crucial which is carrier's biocompatibility with its degradation products. Leucocytes, platelets, erythrocytes, Nano hepatocytes, and fibroblasts etc. have been proposed as carrier structures. these, erythrocytes explored found own better potential in drug delivery. Bio-pharmaceuticals, intensely significant peptides proteins, antigens, anticancer well vaccines, among freshly attentive pharmaceuticals being transported using erythrocytes. Vaccines, drugs recently targeted delivery via Red blood cells, or studied great detail because their possible use vehicles. They special helpful biocompatibility, nonpathogenicity, nonimmunogenicity, biodegradability. To prepare draw from target organism separate plasma. Through variety techniques, entrapped within broken resulting resealed referred "resealed erythrocytes"—the result. Many medications, such aspirin, steroids, Resealed reduce side effects cancer drugs, numerous. The current review focuses on isolation, loading evaluation applications sealed

Язык: Английский

---

Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

Advances in medical technologies and clinical practice book series, Год журнала: 2016, Номер unknown, С. 340 - 366

Опубликована: Авг. 24, 2016

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, present scenario about is emphasizing towards targeted Erythrocytes most common type of blood cells travel thousands miles from wide narrow pathways deliver oxygen, drugs and nutrient during their lifetime. Red have strong potential carrier capabilities for varieties drugs. Drug-loaded erythrocytes or resealed promising various passive active targeting. Resealed erythrocyte advantage over several models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping a variety chemicals, protection organism against effects drug, able circulate throughout body, ideal zero-order drug-release kinetics, no undesired immune response encapsulated etc. rapidly taken up by macrophages Reticuloendothelial System (RES) liver, lung, spleen body hence also. method secure effective targeting specially longer period time. This chapter will explain different loading erythrocytes, characterization, applications in therapies associated health benefits.

Язык: Английский

---