Photons Plus Ultrasound: Imaging and Sensing 2021,
Год журнала:
2024,
Номер
unknown, С. 96 - 96
Опубликована: Фев. 26, 2024
Thermoacoustic
imaging
(TAI)
is
a
promising
new
technology
for
biomedical
diagnostics.
It
combines
the
high
contrast
of
electromagnetic
absorption
with
resolution
ultrasound
imaging.
Traditional
TAI
systems
use
circular
scanning
modes
single
or
arc
detectors,
which
can
be
slow
and
inefficient
body
scanning.
A
linear-array
detector,
commonly
used
in
medical
systems,
to
scan
biological
tissues
more
efficiently.
In
this
study,
we
developed
novel
system
(LATIS)
detection
hemorrhage
brain
through
fontanelle
neonates.
The
LATIS
uses
transducer
multiple
elements,
enables
rapid
data
acquisition
real-time
custom-designed
trigger
mechanism
synchronizes
microwave
signal
generation
process,
ensuring
accurate
timing
optimal
image
quality.
We
evaluated
performance
by
conducting
several
ex-vivo
sheep
different
amounts
artificially
induced
blood.
was
able
successfully
detect
lower
grades
intraventricular
hemorrhages
experiments.
These
results
demonstrate
potential
clinical
neonates
as
they
are
vulnerable
hemorrhage.
Sensors,
Год журнала:
2025,
Номер
25(6), С. 1643 - 1643
Опубликована: Март 7, 2025
Photoacoustic
imaging
(PAI)
is
an
emerging
modality
that
merges
optical
and
ultrasound
to
provide
high-resolution
functional
insights
into
biological
tissues.
This
technique
leverages
the
photoacoustic
effect,
where
tissue
absorbs
pulsed
laser
light,
generating
acoustic
waves
are
captured
reconstruct
images.
While
lasers
have
traditionally
been
light
source
for
PAI,
their
high
cost
complexity
drive
interest
towards
alternative
sources
like
light-emitting
diodes
(LEDs).
study
evaluates
feasibility
of
using
avalanche
oscillator
high-power
LEDs
in
a
basic
system.
An
oscillator,
utilizing
semiconductor
breakdown
produce
high-voltage
pulses,
powers
generate
short,
high-intensity
pulses.
The
system
incorporates
LED
array,
ultrasonic
transducer,
amplifier
signal
detection.
Key
findings
include
successful
generation
short
pulses
with
sufficient
intensity
excite
materials
system’s
capability
detectable
signals
both
air
water
environments.
demonstrate
cost-effectiveness
portability
advantages,
challenges
such
as
lower
power
broader
spectral
bandwidth
compared
noted.
results
affirm
LED-based
systems,
though
currently
less
advanced
than
laser-based
present
promising
direction
affordable
portable
technologies.
Photoacoustics,
Год журнала:
2023,
Номер
32, С. 100538 - 100538
Опубликована: Июль 27, 2023
We
have
developed
and
optimized
an
imaging
system
to
study
improve
the
detection
of
brain
hemorrhage
quantify
oxygenation.
Since
this
is
intended
be
used
for
in
neonates
through
skull
opening,
i.e.,
fontanelle,
we
called
it,
Transfontanelle
Photoacoustic
Imaging
(TFPAI)
system.
The
terms
optical
acoustic
designs,
thermal
safety,
mechanical
stability.
lower
limit
quantification
TFPAI
detect
location
its
size
evaluated
using
in-vitro
ex-vivo
experiments.
capability
measuring
tissue
oxygenation
vasogenic
edema
due
blood
barrier
disruption
are
demonstrated.
results
obtained
from
our
experimental
evaluations
strongly
suggest
potential
utility
TFPAI,
as
a
portable
modality
neonatal
intensive
care
unit.
Confirmation
these
findings
in-vivo
could
facilitate
translation
promising
technology
clinic.
SignificanceThere
are
many
neuroscience
questions
that
can
be
answered
by
a
high-resolution
functional
brain
imaging
system.
Such
system
would
require
the
capability
to
visualize
vasculature
and
measure
neural
activity
entire
continually
in
rapid
succession
order
capture
hemodynamic
changes.
Utilizing
optical
excitation
acoustic
detection,
photoacoustic
technology
enables
label-free
quantification
of
changes
endogenous
chromophores,
such
as
oxyhemoglobin,
deoxyhemoglobin,
total
hemoglobin.AimOur
aim
was
develop
sufficiently
high-resolution,
fast
frame-rate,
wide
field-of-view
(FOV)
microscopy
(PAM)
for
purpose
hemodynamics
rat
brain.ApproachAlthough
most
PA
systems
use
raster
scanning
(or
less
commonly
Lissajous
scanning),
we
have
developed
simple-to-implement
laser
resolution
PAM
with
spiral
(which
named
"spiral
microscopy"
or
sLS-PAM)
acquire
an
18
mm
diameter
image
at
frame
rate
(more
than
1
fps).
is
designed
permit
continuous
without
introduction
photobleaching
artifacts.ConclusionWe
demonstrated
sLS-PAM
cerebral
response
whisker
electrical
stimulation
used
it
vascular
modeled
injury.
We
believe
development
system,
which
could
become
affordable
neuroimaging
tool
researchers.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Сен. 13, 2022
Abstract
The
capability
of
photoacoustic
(PA)
imaging
to
measure
oxygen
saturation
through
a
fontanelle
has
been
demonstrated
in
large
animals
in-vivo
.
We
called
this
method,
transfontanelle
(TFPAI).
A
surgically
induced
2.5
cm
diameter
cranial
window
was
created
an
adult
sheep
skull
model
the
human
anterior
fontanelle.
performance
TFPAI
evaluated
by
comparing
PA-based
predicted
results
against
gold
standard
blood
gas
analyzer
measurements.
Chemosensors,
Год журнала:
2022,
Номер
10(5), С. 181 - 181
Опубликована: Май 9, 2022
Acoustic
biosensors
are
widely
used
in
physical,
chemical,
and
biosensing
applications.
One
of
the
major
concerns
acoustic
is
delicacy
medium
through
which
waves
propagate
reach
sensors.
Even
a
small
airgap
diminishes
signal
strengths
due
to
high
impedance
mismatch.
Therefore,
presence
coupling
create
pathway
for
an
efficient
propagation
essential.
Here,
we
have
reviewed
characteristics
various
material
(liquid,
gel-based,
semi-dry,
dry)
present
guide
determine
suitable
application-specific
medium.
Journal of Biophotonics,
Год журнала:
2022,
Номер
15(6)
Опубликована: Март 14, 2022
One
of
the
key
challenges
in
linear
array
transducer-based
photoacoustic
computed
tomography
is
to
image
structures
embedded
deep
within
biological
tissue
with
limited
optical
energy.
Here,
we
utilized
a
manually
controlled
multi-angle
illumination
technique
allow
incident
photons
interact
imaging
targets
for
longer
periods
time
and
diffuse
further
all
directions.
We
have
developed
optimized
compact
probe
that
enables
manual
changes
angle
while
acquiring
signals.
The
performance
has
been
demonstrated
evaluated
by
complex
blood
vessel
mimicking
phantoms
in-vitro
sheep
brain
samples
ex-vivo.
For
effective
reconstruction
from
data
acquired
method,
method
based
on
extraction
maximum
intensity.
In
both
cases,
out-performed
conventional
fixed
improve
overall
quality.
Specifically,
located
at
greater
axial
depths
was
possible
using
this
technique.
Photoacoustics,
Год журнала:
2023,
Номер
33, С. 100549 - 100549
Опубликована: Авг. 24, 2023
Intraventricular
(IVH)
and
periventricular
(PVH)
hemorrhages
in
preterm
neonates
are
common
because
the
blood
vessels
still
developing
up
to
36
weeks
fragile.
Currently,
transfontanelle
ultrasound
(US)
imaging
is
utilized
for
screening
IVH
PVH,
largely
through
anterior
fontanelle.
However
mild
hemorrhages,
inconclusive
diagnoses
common,
leading
failure
detect
IVH/PVH
or,
when
other
clinical
symptoms
present,
use
of
second
stage
neuroimaging
modalities
requiring
transport
vulnerable
patients.
Yet
even
increases
risk
moderate-severe
neurodevelopmental
impairment.
Here,
we
demonstrate
capability
photoacoustic
(TFPAI)
PVH
in-vivo
a
large
animal
model.
TFPAI
was
able
as
small
0.3
mL
volume
brain
(p
<
0.05).
By
contrast,
US
0.5
mL.
These
preliminary
results
suggest
could
be
translated
into
portable
bedside
probe
improved
diagnosis
clinically
relevant
neonates.
Journal of Biophotonics,
Год журнала:
2023,
Номер
17(3)
Опубликована: Ноя. 28, 2023
Abstract
Various
reconstruction
algorithms
have
been
implemented
for
linear
array
photoacoustic
imaging
systems
with
the
goal
of
accurately
reconstructing
strength
absorbers
within
tissue
being
imaged.
Since
existing
introduced
by
different
research
groups
and
context
performance
evaluation
was
not
consistent,
it
is
difficult
to
make
a
fair
comparison
between
them.
In
this
study,
we
systematically
compared
10
published
image
(DAS,
UBP,
pDAS,
DMAS,
MV,
EIGMV,
SLSC,
GSC,
TR,
FD)
using
in‐vitro
phantom
data.
Evaluations
were
conducted
based
on
lateral
resolution
reconstructed
images,
computational
time,
target
detectability,
noise
sensitivity.
We
anticipate
outcome
study
will
assist
researchers
in
selecting
appropriate
their
PA
applications.
Journal of Biophotonics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
The
use
of
photoacoustic
brain
imaging
for
hemorrhage
detection
holds
significant
clinical
importance.
This
study
focuses
on
the
performance
sensitivity
and
capabilities
a
single-element
scanning
system,
considering
remarkable
signal-to-noise
ratio
signals
generated
by
transducer.
By
employing
blood
vessel-like
phantoms
ex
vivo
phantoms,
we
demonstrated
superior
efficacy
method
over
transducer
array
system
in
context
detection.
research
highlights
potential
enhancing
through
careful
design
optimization
proposed
method,
thereby
increasing
its
viability
application.
Photonics,
Год журнала:
2025,
Номер
12(4), С. 385 - 385
Опубликована: Апрель 16, 2025
Typically,
multi-single-element
photoacoustic
computed
tomography
(PACT)
systems
utilize
numerous
ultrasound
transducers
arranged
in
cylindrical
or
hemispherical
configurations
for
detection,
combined
with
a
single
diffuse
light
source
multiple
sparse
sources
to
illuminate
the
imaging
target.
While
these
produce
high-quality
3D
PA
images,
they
require
complex,
multi-channel
data
acquisition
(DAQ)
acquire
from
all
transducers.
These
DAQ
are
often
bulky
and
expensive,
significantly
limiting
clinical
translation
of
PACT
patient
care.
In
this
study,
we
evaluated
feasibility
using
compact
cost-effective
Texas
Instruments
analog
front-end
module
systems.
By
simple
phantom,
demonstrated
capability
affordable
board,
reconstructed
images
showing
promise
practical
economical
solutions
This
advancement
paves
way
broader
applications
both
research
settings.