Informative OCT radiomic features towards improved melanoma detection DOI
Brandon Lukas, Maria M. Tsoukas, Kamran Avanaki

et al.

Published: Jan. 21, 2022

Survival from melanoma, the deadliest form of skin cancer, depends heavily on early detection. Several non-invasive medical imaging modalities have been developed to detect which optical coherence tomography (OCT) is gaining popularity. Although OCT generally does not yet provide sufficient performance in detecting radiomic studies involving quantitative image analysis demonstrate promising results. We propose extracting a large set features images skin, exploring how differ between melanoma and non-melanoma, performing feature selection identify most informative that characterize for improved

Language: Английский

Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo DOI Creative Commons
Rayyan Manwar,

Karl Kratkiewicz,

Sadreddin Mahmoodkalayeh

et al.

Photoacoustics, Journal Year: 2023, Volume and Issue: 32, P. 100538 - 100538

Published: July 27, 2023

We have developed and optimized an imaging system to study improve the detection of brain hemorrhage quantify oxygenation. Since this is intended be used for in neonates through skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The terms optical acoustic designs, thermal safety, mechanical stability. lower limit quantification TFPAI detect location its size evaluated using in-vitro ex-vivo experiments. capability measuring tissue oxygenation vasogenic edema due blood barrier disruption are demonstrated. results obtained from our experimental evaluations strongly suggest potential utility TFPAI, as a portable modality neonatal intensive care unit. Confirmation these findings in-vivo could facilitate translation promising technology clinic.

Language: Английский

Citations

18
Spiral laser scanning photoacoustic microscopy for functional brain imaging in rats DOI Creative Commons
Mohsin Zafar, Laura Stone McGuire, Seyed Mohsen Ranjbaran

et al.

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(01)

Published: Feb. 9, 2024

SignificanceThere are many neuroscience questions that can be answered by a high-resolution functional brain imaging system. Such system would require the capability to visualize vasculature and measure neural activity entire continually in rapid succession order capture hemodynamic changes. Utilizing optical excitation acoustic detection, photoacoustic technology enables label-free quantification of changes endogenous chromophores, such as oxyhemoglobin, deoxyhemoglobin, total hemoglobin.AimOur aim was develop sufficiently high-resolution, fast frame-rate, wide field-of-view (FOV) microscopy (PAM) for purpose hemodynamics rat brain.ApproachAlthough most PA systems use raster scanning (or less commonly Lissajous scanning), we have developed simple-to-implement laser resolution PAM with spiral (which named "spiral microscopy" or sLS-PAM) acquire an 18 mm diameter image at frame rate (more than 1 fps). is designed permit continuous without introduction photobleaching artifacts.ConclusionWe demonstrated sLS-PAM cerebral response whisker electrical stimulation used it vascular modeled injury. We believe development system, which could become affordable neuroimaging tool researchers.

Language: Английский

Citations

7
Cost-Effective Photoacoustic Imaging Using High-Power Light-Emitting Diodes Driven by an Avalanche Oscillator DOI Creative Commons
Alberto Prud’homme, Frédéric Nabki

Sensors, Journal Year: 2025, Volume and Issue: 25(6), P. 1643 - 1643

Published: March 7, 2025

Photoacoustic imaging (PAI) is an emerging modality that merges optical and ultrasound to provide high-resolution functional insights into biological tissues. This technique leverages the photoacoustic effect, where tissue absorbs pulsed laser light, generating acoustic waves are captured reconstruct images. While lasers have traditionally been light source for PAI, their high cost complexity drive interest towards alternative sources like light-emitting diodes (LEDs). study evaluates feasibility of using avalanche oscillator high-power LEDs in a basic system. An oscillator, utilizing semiconductor breakdown produce high-voltage pulses, powers generate short, high-intensity pulses. The system incorporates LED array, ultrasonic transducer, amplifier signal detection. Key findings include successful generation short pulses with sufficient intensity excite materials system’s capability detectable signals both air water environments. demonstrate cost-effectiveness portability advantages, challenges such as lower power broader spectral bandwidth compared noted. results affirm LED-based systems, though currently less advanced than laser-based present promising direction affordable portable technologies.

Language: Английский

Citations

1
Transfontanelle photoacoustic imaging for in-vivo cerebral oxygenation measurement DOI Creative Commons
Rayyan Manwar, Laura Stone McGuire, Md Tarikul Islam

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Sept. 13, 2022

Abstract The capability of photoacoustic (PA) imaging to measure oxygen saturation through a fontanelle has been demonstrated in large animals in-vivo . We called this method, transfontanelle (TFPAI). A surgically induced 2.5 cm diameter cranial window was created an adult sheep skull model the human anterior fontanelle. performance TFPAI evaluated by comparing PA-based predicted results against gold standard blood gas analyzer measurements.

Language: Английский

Citations

26
Couplants in Acoustic Biosensing Systems DOI Creative Commons
Rayyan Manwar, Loïc Saint‐Martin, Kamran Avanaki

et al.

Chemosensors, Journal Year: 2022, Volume and Issue: 10(5), P. 181 - 181

Published: May 9, 2022

Acoustic biosensors are widely used in physical, chemical, and biosensing applications. One of the major concerns acoustic is delicacy medium through which waves propagate reach sensors. Even a small airgap diminishes signal strengths due to high impedance mismatch. Therefore, presence coupling create pathway for an efficient propagation essential. Here, we have reviewed characteristics various material (liquid, gel-based, semi-dry, dry) present guide determine suitable application-specific medium.

Language: Английский

Citations

21
Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain DOI Creative Commons
Rayyan Manwar, Juliana Benavides, Ravi Prakash

et al.

Journal of Biophotonics, Journal Year: 2022, Volume and Issue: 15(6)

Published: March 14, 2022

One of the key challenges in linear array transducer-based photoacoustic computed tomography is to image structures embedded deep within biological tissue with limited optical energy. Here, we utilized a manually controlled multi-angle illumination technique allow incident photons interact imaging targets for longer periods time and diffuse further all directions. We have developed optimized compact probe that enables manual changes angle while acquiring signals. The performance has been demonstrated evaluated by complex blood vessel mimicking phantoms in-vitro sheep brain samples ex-vivo. For effective reconstruction from data acquired method, method based on extraction maximum intensity. In both cases, out-performed conventional fixed improve overall quality. Specifically, located at greater axial depths was possible using this technique.

Language: Английский

Citations

20
Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep DOI Creative Commons
Juliana Benavides, Rayyan Manwar, Laura Stone McGuire

et al.

Photoacoustics, Journal Year: 2023, Volume and Issue: 33, P. 100549 - 100549

Published: Aug. 24, 2023

Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are common because the blood vessels still developing up to 36 weeks fragile. Currently, transfontanelle ultrasound (US) imaging is utilized for screening IVH PVH, largely through anterior fontanelle. However mild hemorrhages, inconclusive diagnoses common, leading failure detect IVH/PVH or, when other clinical symptoms present, use of second stage neuroimaging modalities requiring transport vulnerable patients. Yet even increases risk moderate-severe neurodevelopmental impairment. Here, we demonstrate capability photoacoustic (TFPAI) PVH in-vivo a large animal model. TFPAI was able as small 0.3 mL volume brain (p < 0.05). By contrast, US 0.5 mL. These preliminary results suggest could be translated into portable bedside probe improved diagnosis clinically relevant neonates.

Language: Английский

Citations

12
Evaluation of 10 current image reconstruction algorithms for linear array photoacoustic imaging DOI Creative Commons

Ravi Prakash,

Rayyan Manwar, Kamran Avanaki

et al.

Journal of Biophotonics, Journal Year: 2023, Volume and Issue: 17(3)

Published: Nov. 28, 2023

Abstract Various reconstruction algorithms have been implemented for linear array photoacoustic imaging systems with the goal of accurately reconstructing strength absorbers within tissue being imaged. Since existing introduced by different research groups and context performance evaluation was not consistent, it is difficult to make a fair comparison between them. In this study, we systematically compared 10 published image (DAS, UBP, pDAS, DMAS, MV, EIGMV, SLSC, GSC, TR, FD) using in‐vitro phantom data. Evaluations were conducted based on lateral resolution reconstructed images, computational time, target detectability, noise sensitivity. We anticipate outcome study will assist researchers in selecting appropriate their PA applications.

Language: Английский

Citations

9
Assessment of a Single‐Element Scanning System for Enhanced Photoacoustic Imaging of Brain Hemorrhage DOI Creative Commons
Juliana Benavides,

Ravi Prakash,

Kamran Avanaki

et al.

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The use of photoacoustic brain imaging for hemorrhage detection holds significant clinical importance. This study focuses on the performance sensitivity and capabilities a single-element scanning system, considering remarkable signal-to-noise ratio signals generated by transducer. By employing blood vessel-like phantoms ex vivo phantoms, we demonstrated superior efficacy method over transducer array system in context detection. research highlights potential enhancing through careful design optimization proposed method, thereby increasing its viability application.

Language: Английский

Citations

0
Utility of Low-Cost Multichannel Data Acquisition System for Photoacoustic Computed Tomography DOI Creative Commons
Mohsin Zafar, Rayyan Manwar, Seyed Mohsen Ranjbaran

et al.

Photonics, Journal Year: 2025, Volume and Issue: 12(4), P. 385 - 385

Published: April 16, 2025

Typically, multi-single-element photoacoustic computed tomography (PACT) systems utilize numerous ultrasound transducers arranged in cylindrical or hemispherical configurations for detection, combined with a single diffuse light source multiple sparse sources to illuminate the imaging target. While these produce high-quality 3D PA images, they require complex, multi-channel data acquisition (DAQ) acquire from all transducers. These DAQ are often bulky and expensive, significantly limiting clinical translation of PACT patient care. In this study, we evaluated feasibility using compact cost-effective Texas Instruments analog front-end module systems. By simple phantom, demonstrated capability affordable board, reconstructed images showing promise practical economical solutions This advancement paves way broader applications both research settings.

Language: Английский

Citations

0