PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0318237 - e0318237
Опубликована: Фев. 28, 2025
Background
Perinatal
maternal
stress,
which
includes
both
psychological
and
physiological
stress
experienced
by
healthy
women
during
pregnancy
the
postpartum
period,
is
becoming
increasingly
prevalent.
Infant
early
exposure
to
adverse
environments
such
as
perinatal
has
been
shown
increase
long-term
risk
metabolic,
immunologic
neurobehavioral
disorders.
Evidence
suggests
that
human
microbiome
facilitates
transmission
of
factors
infants
via
vaginal,
gut,
milk
microbiomes.
The
colonization
aberrant
microorganisms
in
mother’s
microbiome,
influenced
microbiome-brain-gut
axis,
may
be
transferred
a
critical
developmental
period.
This
transfer
predispose
more
inflammatory-prone
associated
with
dysregulated
metabolic
process
leading
health
outcomes.
Given
prevalence
potential
impact
on
infant
health,
no
systematic
mapping
or
review
data
date,
aim
this
scoping
gather
evidence
relationship
between
milk,
maternal,
gut
Methods
an
exploratory
review,
guided
Joanna
Briggs
Institute’s
methodology
along
use
Prisma
Scr
reporting
guideline.
A
comprehensive
search
was
conducted
using
following
databases,
CINAHL
Complete;
MEDLINE;
PsycINFO,
Web
Science
Scopus
protocol
registered
Open
Framework
DOI
10.17605/OSF.IO/5SRMV.
Results
After
screening
1145
papers
there
were
7
paper
met
inclusion
criteria.
Statistically
significant
associations
found
five
studies
identify
higher
abundance
potentially
pathogenic
bacteria
Erwinia,
Serratia,
T
mayombie,
Bacteroides
lower
levels
linked
beneficial
Lactococcus,
Lactobacillus,
Akkermansia.
However,
one
study
presents
conflicting
results
where
it
reported
bacteria.
Conclusion
does
have
alteration
diversity
influential
however,
can
affect
colonisation
different
ways.
These
bacterial
changes
capacity
influence
long
term
disease.
analyses
collection
tools
methods,
offers
reasons
for
these
findings
well
suggestions
future
research.
Science,
Год журнала:
2022,
Номер
377(6612), С. 1328 - 1332
Опубликована: Сен. 15, 2022
The
gut
microbiomes
of
human
populations
worldwide
have
many
core
microbial
species
in
common.
However,
within
a
species,
some
strains
can
show
remarkable
population
specificity.
question
is
whether
such
specificity
arises
from
shared
evolutionary
history
(codiversification)
between
humans
and
their
microbes.
To
test
for
codiversification
host
microbiota,
we
analyzed
paired
metagenomes
genomes
1225
individuals
Europe,
Asia,
Africa,
including
mothers
children.
Between
countries,
parallel
was
evident
Moreover,
displaying
the
strongest
independently
evolved
traits
characteristic
dependency,
reduced
oxygen
temperature
sensitivity.
These
findings
all
point
to
importance
understanding
potential
role
population-specific
microbiome-mediated
disease
phenotypes.
Cell,
Год журнала:
2023,
Номер
186(14), С. 3111 - 3124.e13
Опубликована: Июнь 21, 2023
The
gut
microbiome
modulates
immune
and
metabolic
health.
Human
data
are
biased
toward
industrialized
populations,
limiting
our
understanding
of
non-industrialized
microbiomes.
Here,
we
performed
ultra-deep
metagenomic
sequencing
on
351
fecal
samples
from
the
Hadza
hunter-gatherers
Tanzania
comparative
populations
in
Nepal
California.
We
recovered
91,662
genomes
bacteria,
archaea,
bacteriophages,
eukaryotes,
44%
which
absent
existing
unified
datasets.
identified
124
gut-resident
species
vanishing
highlighted
distinct
aspects
related
to
situ
replication
rates,
signatures
selection,
strain
sharing.
Industrialized
microbes
were
found
be
enriched
genes
associated
with
oxidative
stress,
possibly
a
result
adaptation
inflammatory
processes.
This
unparalleled
view
provides
valuable
resource,
expands
capable
colonizing
human
gut,
clarifies
extensive
perturbation
induced
by
lifestyle.
Experimental & Molecular Medicine,
Год журнала:
2024,
Номер
56(7), С. 1501 - 1512
Опубликована: Июль 1, 2024
Abstract
Recent
substantial
evidence
implicating
commensal
bacteria
in
human
diseases
has
given
rise
to
a
new
domain
biomedical
research:
microbiome
medicine.
This
emerging
field
aims
understand
and
leverage
the
microbiota
derivative
molecules
for
disease
prevention
treatment.
Despite
complex
hierarchical
organization
of
this
ecosystem,
most
research
over
years
relied
on
16S
amplicon
sequencing,
legacy
bacterial
phylogeny
taxonomy.
Although
advanced
sequencing
technologies
have
enabled
cost-effective
analysis
entire
microbiota,
translating
relatively
short
nucleotide
information
into
functional
taxonomic
posed
challenges
until
recently.
In
last
decade,
genome-resolved
metagenomics,
which
reconstruct
microbial
genomes
directly
from
whole-metagenome
data,
made
significant
strides
continues
unveil
mysteries
various
human-associated
communities.
There
been
rapid
increase
volume
whole
metagenome
data
compilation
novel
metagenome-assembled
protein
sequences
public
depositories.
review
provides
an
overview
capabilities
methods
metagenomics
studying
microbiome,
with
focus
investigating
prokaryotic
gut.
Just
as
decoding
genome
its
variations
marked
beginning
genomic
medicine
era,
unraveling
microbes
their
sequence
is
ushering
us
era
Genome-resolved
stands
pivotal
tool
transition
can
accelerate
our
journey
toward
achieving
these
scientific
medical
milestones.
The
factors
shaping
human
microbiome
variation
are
a
major
focus
of
biomedical
research.
While
other
fields
have
used
large
sequencing
compendia
to
extract
insights
requiring
otherwise
impractical
sample
sizes,
the
field
has
lacked
comparably
sized
resource
for
16S
rRNA
gene
amplicon
commonly
quantify
composition.
To
address
this
gap,
we
processed
168,464
publicly
available
gut
samples
with
uniform
pipeline.
We
use
compendium
evaluate
geographic
and
technical
effects
on
variation.
find
that
regions
such
as
Central
Southern
Asia
differ
significantly
from
more
thoroughly
characterized
microbiomes
Europe
Northern
America
composition
alone
can
be
predict
sample's
region
origin.
also
strong
associations
between
primers
DNA
extraction.
anticipate
growing
work,
Human
Microbiome
Compendium,
will
enable
advanced
applied
methodological
The
development
of
the
gut
microbiome
is
crucial
to
human
health,
particularly
during
first
three
years
life.
Given
its
role
in
immune
development,
disturbances
establishment
process
may
have
long
term
consequences.
This
review
summarizes
evidence
for
these
claims,
highlighting
compositional
changes
this
critical
period
life
as
well
factors
that
affect
development.
Based
on
and
animal
data,
we
conclude
early-life
a
determinant
long-term
impacting
physiological,
metabolic,
processes.
field
faces
challenges.
Some
challenges
are
technical,
such
lack
standardized
stool
collection
protocols,
inconsistent
DNA
extraction
methods,
outdated
sequencing
technologies.
Other
methodological:
small
sample
sizes,
longitudinal
studies,
poor
control
confounding
variables.
To
address
limitations,
advocate
more
robust
research
methodologies
better
understand
microbiome's
health
disease.
Improved
methods
will
lead
reliable
studies
deeper
understanding
impact
outcomes.
