mosGILT controls innate immunity and germ cell development in Anopheles gambiae
BMC Genomics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Янв. 9, 2024
Gene-edited
mosquitoes
lacking
a
gamma-interferon-inducible
lysosomal
thiol
reductase-like
protein,
namely
(mosGILT
Язык: Английский
Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
379(1901)
Опубликована: Март 18, 2024
Interactions
between
animals
and
microbes
are
ubiquitous
in
nature
strongly
impact
animal
physiology.
These
interactions
shaped
by
the
host
immune
system,
which
responds
to
infections
contributes
tailor
associations
with
beneficial
microorganisms.
In
many
insects,
symbiotic
not
only
include
gut
commensals,
but
also
intracellular
bacteria,
or
endosymbionts.
Endosymbionts
housed
within
specialized
cells,
bacteriocytes,
transmitted
vertically
across
generations.
Host–endosymbiont
co-evolution
shapes
endosymbiont
genome
fights
against
microbial
intruders,
ensures
preservation
of
endosymbionts
control
their
load
location.
The
cereal
weevil
Sitophilus
spp.
is
a
remarkable
model
study
evolutionary
adaptation
system
endosymbiosis
owing
its
binary
association
unique,
relatively
recently
acquired
nutritional
endosymbiont,
Sodalis
pierantonius
.
This
Gram-negative
bacterium
has
experienced
size
shrinkage
observed
long-term
endosymbioses
retained
immunogenicity.
We
focus
here
on
sixteen
antimicrobial
peptides
(AMPs)
identified
oryzae
expression
patterns
different
tissues,
along
development
upon
challenges,
address
potential
functions
defensive
response
homeostasis
insect
life
cycle.
article
part
theme
issue
‘Sculpting
microbiome:
how
factors
determine
respond
colonization’.
Язык: Английский
Untangling the gordian knot: The intertwining interactions between developmental hormone signaling and epigenetic mechanisms in insects
Molecular and Cellular Endocrinology,
Год журнала:
2024,
Номер
585, С. 112178 - 112178
Опубликована: Фев. 9, 2024
Язык: Английский
Expression of Toll-like receptors in the cerebellum during pathogenesis of prion disease
Frontiers in Behavioral Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Апрель 18, 2024
Prion
diseases,
such
as
scrapie,
entail
the
accumulation
of
disease-specific
prion
protein
(PrPSc)
within
brain.
Toll-like
receptors
(TLRs)
are
crucial
components
pattern
recognition
system.
They
recognize
pathogen-associated
molecular
patterns
(PAMPs)
and
play
a
central
role
in
orchestrating
host
innate
immune
responses.
The
expression
levels
nervous
system
(CNS)
were
not
well-defined.
To
establish
model
diseases
BALB/C
mice,
22L
strain
was
employed.
features
analyzed,
cerebellum
exhibited
severe
pathological
changes.
TLR1-13
measured
using
quantitative
polymerase
chain
reaction
(qPCR)
at
time
points
60,
90,
120,
final
end
point
(145
days
post-infection).
During
pathogenesis,
1,
2,
7,
8,
9
increased
time-dependent
manner.
This
trend
mirrored
PrPSc
(the
isoform
protein)
glial
fibrillary
acidic
protein.
Notably,
point,
significantly
elevated.
Protein
level
TLR7
TLR9
showed
increasing
22L-infected
mice.
A
deeper
understanding
could
shed
light
on
their
initiating
responses
various
stages
during
pathogenesis.
insight
is
particularly
relevant
when
considering
TLRs
potential
therapeutic
targets
for
diseases.
Язык: Английский
Ecdysone promotes gene- and pathogen-specific immune responses to Micrococcus luteus and Bacillus subtilis in Drosophila S2 cells
Journal of Insect Physiology,
Год журнала:
2024,
Номер
159, С. 104710 - 104710
Опубликована: Сен. 15, 2024
Язык: Английский
Pathogen-Mediated Alterations of Insect Chemical Communication: From Pheromones to Behavior
Pathogens,
Год журнала:
2023,
Номер
12(11), С. 1350 - 1350
Опубликована: Ноя. 14, 2023
Pathogens
can
influence
the
physiology
and
behavior
of
both
animal
plant
hosts
in
a
manner
that
promotes
their
own
transmission
dispersal.
Recent
research
focusing
on
insects
has
revealed
these
manipulations
extend
to
production
pheromones,
which
are
pivotal
chemical
communication.
This
review
provides
an
overview
current
state
available
data
concerning
impacts
bacterial,
viral,
fungal,
eukaryotic
pathogens
communication
across
different
insect
orders.
While
our
understanding
pathogenic
bacteria
host
profiles
is
still
limited,
viral
infections
have
been
shown
induce
behavioral
changes
host,
such
as
altered
pheromone
production,
olfaction,
locomotion.
Entomopathogenic
fungi
affect
by
manipulating
cuticular
hydrocarbons
while
various
parasites
observed
affecting
pheromones
other
cues.
The
effects
induced
explored
context
evolutionary
advantages
they
confer
pathogen.
molecular
mechanisms
governing
pathogen-mediated
changes,
well
dynamic
mutually
influential
relationships
between
pathogen
its
poorly
understood.
A
deeper
comprehension
will
prove
invaluable
identifying
novel
targets
perspective
practical
applications
aimed
at
controlling
detrimental
species.
Язык: Английский
Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin
iScience,
Год журнала:
2024,
Номер
27(9), С. 110662 - 110662
Опубликована: Авг. 3, 2024
Airway
epithelial
cells
represent
the
first
line
of
defense
against
respiratory
pathogens.
Flagellin
drives
motility
many
mucosal
pathogens
and
has
been
suggested
as
an
immune
enhancing
adjunctive
therapeutic
in
infections
airways.
This
study
leveraged
single-cell
RNA
sequencing
to
determine
cell-specific
effects
flagellin
primary
human
bronchial
growing
air-liquid
interface.
Seven
cell
clusters
were
identified,
including
ciliated
cells,
ionocytes,
several
states
basal
secretory
which
only
inflammatory
demonstrated
a
proportional
increase
response
flagellin.
Inflammatory
showed
evidence
metabolic
reprogramming
toward
aerobic
glycolysis,
while
transcriptome
profiles
indicated
enhanced
oxidative
phosphorylation.
Inhibition
mTOR
prevented
shift
glycolysis
reduced
gene
transcription
specifically
cells.
These
data
demonstrate
functional
heterogeneity
airway
epithelium
upon
exposure
Язык: Английский
Yorkie Negatively Regulates the Antimicrobial Peptide Expression During Molting Process in Chinese Mitten Crab, Eriocheir Sinensis
Опубликована: Янв. 1, 2024
Язык: Английский
Yorkie negatively regulates the Crustin expression during molting in Chinese mitten crab, Eriocheir sinensis
Developmental & Comparative Immunology,
Год журнала:
2024,
Номер
161, С. 105242 - 105242
Опубликована: Авг. 14, 2024
Язык: Английский
Cereal Weevil’s Antimicrobial Peptides: At the Crosstalk between Development, Endosymbiosis and Immune Response
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 29, 2023
Summary
Interactions
between
animals
and
microbes
are
ubiquitous
in
nature
strongly
impact
animal
physiology.
These
interactions
shaped
by
the
host
immune
system,
which
responds
to
infections
contributes
tailor
associations
with
beneficial
microorganisms.
In
many
insects,
symbiotic
not
only
include
gut
commensals,
but
also
intracellular
bacteria,
or
endosymbionts.
Endosymbionts
housed
within
specialised
cells,
bacteriocytes,
transmitted
vertically
across
generations.
Host-endosymbiont
co-evolution
shapes
endosymbiont
genome
fights
against
microbial
intruders,
ensures
preservation
of
endosymbionts
control
their
load
location.
The
cereal
weevil
Sitophilus
spp.
is
a
remarkable
model
study
evolutionary
adaptation
system
endosymbiosis
since
its
binary
association
unique,
relatively
recently
acquired
nutritional
endosymbiont,
Sodalis
pierantonius
.
This
Gram-negative
bacterium
has
experienced
size
shrinkage
observed
long-term
endosymbioses
retained
immunogenicity.
We
focus
here
on
16
antimicrobial
peptides
(AMPs)
identified
oryzae
expression
patterns
different
tissues,
along
development
upon
challenges,
address
potential
functions
defensive
response
homeostasis
insect
life
cycle.
Язык: Английский