Developmental & Comparative Immunology, Год журнала: 2024, Номер 161, С. 105242 - 105242
Опубликована: Авг. 14, 2024
Язык: Английский
Developmental & Comparative Immunology, Год журнала: 2024, Номер 161, С. 105242 - 105242
Опубликована: Авг. 14, 2024
Язык: Английский
BMC Genomics, Год журнала: 2024, Номер 25(1)
Опубликована: Янв. 9, 2024
Gene-edited mosquitoes lacking a gamma-interferon-inducible lysosomal thiol reductase-like protein, namely (mosGILT
Язык: Английский
Процитировано
5Molecular and Cellular Endocrinology, Год журнала: 2024, Номер 585, С. 112178 - 112178
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
5Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1901)
Опубликована: Март 18, 2024
Interactions between animals and microbes are ubiquitous in nature strongly impact animal physiology. These interactions shaped by the host immune system, which responds to infections contributes tailor associations with beneficial microorganisms. In many insects, symbiotic not only include gut commensals, but also intracellular bacteria, or endosymbionts. Endosymbionts housed within specialized cells, bacteriocytes, transmitted vertically across generations. Host–endosymbiont co-evolution shapes endosymbiont genome fights against microbial intruders, ensures preservation of endosymbionts control their load location. The cereal weevil Sitophilus spp. is a remarkable model study evolutionary adaptation system endosymbiosis owing its binary association unique, relatively recently acquired nutritional endosymbiont, Sodalis pierantonius . This Gram-negative bacterium has experienced size shrinkage observed long-term endosymbioses retained immunogenicity. We focus here on sixteen antimicrobial peptides (AMPs) identified oryzae expression patterns different tissues, along development upon challenges, address potential functions defensive response homeostasis insect life cycle. article part theme issue ‘Sculpting microbiome: how factors determine respond colonization’.
Язык: Английский
Процитировано
5Elsevier eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Communications Biology, Год журнала: 2025, Номер 8(1)
Опубликована: Апрель 23, 2025
Cystic fibrosis (CF) is a genetic disease caused by dysfunction in the Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. Patients with CF are hypersusceptible to Mycobacterium abscessus infection, fast-growing mycobacterium and harmful opportunistic pathogen. Although CFTR known as host susceptibility factor for M. functional impact of trimeric Epithelial sodium Channel (ENaC), whose activity negatively regulated CFTR, towards infection has not been explored yet. To address this issue, we took advantage miR-263a deficient Drosophila presenting CF-like phenotype due ENaC hyperactivity (ENaC+ ). We observed that ENaC+ flies were Cftr-deficient flies. The hypersensitivity was fully rescued blocking hyperactivity, both chemically genetically. Furthermore, per se detrimental Drosophila, they unable mount an efficient humoral immune response. Upon failed upregulate 20-hydroxyecdysone production, which subsequently altered production protective antimicrobial peptides against abscessus. Overall, our results show plays key role and, correlatively other pathogens.
Язык: Английский
Процитировано
0Frontiers in Behavioral Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Апрель 18, 2024
Prion diseases, such as scrapie, entail the accumulation of disease-specific prion protein (PrPSc) within brain. Toll-like receptors (TLRs) are crucial components pattern recognition system. They recognize pathogen-associated molecular patterns (PAMPs) and play a central role in orchestrating host innate immune responses. The expression levels nervous system (CNS) were not well-defined. To establish model diseases BALB/C mice, 22L strain was employed. features analyzed, cerebellum exhibited severe pathological changes. TLR1-13 measured using quantitative polymerase chain reaction (qPCR) at time points 60, 90, 120, final end point (145 days post-infection). During pathogenesis, 1, 2, 7, 8, 9 increased time-dependent manner. This trend mirrored PrPSc (the isoform protein) glial fibrillary acidic protein. Notably, point, significantly elevated. Protein level TLR7 TLR9 showed increasing 22L-infected mice. A deeper understanding could shed light on their initiating responses various stages during pathogenesis. insight is particularly relevant when considering TLRs potential therapeutic targets for diseases.
Язык: Английский
Процитировано
2Journal of Insect Physiology, Год журнала: 2024, Номер 159, С. 104710 - 104710
Опубликована: Сен. 15, 2024
Язык: Английский
Процитировано
2Pathogens, Год журнала: 2023, Номер 12(11), С. 1350 - 1350
Опубликована: Ноя. 14, 2023
Pathogens can influence the physiology and behavior of both animal plant hosts in a manner that promotes their own transmission dispersal. Recent research focusing on insects has revealed these manipulations extend to production pheromones, which are pivotal chemical communication. This review provides an overview current state available data concerning impacts bacterial, viral, fungal, eukaryotic pathogens communication across different insect orders. While our understanding pathogenic bacteria host profiles is still limited, viral infections have been shown induce behavioral changes host, such as altered pheromone production, olfaction, locomotion. Entomopathogenic fungi affect by manipulating cuticular hydrocarbons while various parasites observed affecting pheromones other cues. The effects induced explored context evolutionary advantages they confer pathogen. molecular mechanisms governing pathogen-mediated changes, well dynamic mutually influential relationships between pathogen its poorly understood. A deeper comprehension will prove invaluable identifying novel targets perspective practical applications aimed at controlling detrimental species.
Язык: Английский
Процитировано
4iScience, Год журнала: 2024, Номер 27(9), С. 110662 - 110662
Опубликована: Авг. 3, 2024
Airway epithelial cells represent the first line of defense against respiratory pathogens. Flagellin drives motility many mucosal pathogens and has been suggested as an immune enhancing adjunctive therapeutic in infections airways. This study leveraged single-cell RNA sequencing to determine cell-specific effects flagellin primary human bronchial growing air-liquid interface. Seven cell clusters were identified, including ciliated cells, ionocytes, several states basal secretory which only inflammatory demonstrated a proportional increase response flagellin. Inflammatory showed evidence metabolic reprogramming toward aerobic glycolysis, while transcriptome profiles indicated enhanced oxidative phosphorylation. Inhibition mTOR prevented shift glycolysis reduced gene transcription specifically cells. These data demonstrate functional heterogeneity airway epithelium upon exposure
Язык: Английский
Процитировано
1bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Сен. 29, 2023
Summary Interactions between animals and microbes are ubiquitous in nature strongly impact animal physiology. These interactions shaped by the host immune system, which responds to infections contributes tailor associations with beneficial microorganisms. In many insects, symbiotic not only include gut commensals, but also intracellular bacteria, or endosymbionts. Endosymbionts housed within specialised cells, bacteriocytes, transmitted vertically across generations. Host-endosymbiont co-evolution shapes endosymbiont genome fights against microbial intruders, ensures preservation of endosymbionts control their load location. The cereal weevil Sitophilus spp. is a remarkable model study evolutionary adaptation system endosymbiosis since its binary association unique, relatively recently acquired nutritional endosymbiont, Sodalis pierantonius . This Gram-negative bacterium has experienced size shrinkage observed long-term endosymbioses retained immunogenicity. We focus here on 16 antimicrobial peptides (AMPs) identified oryzae expression patterns different tissues, along development upon challenges, address potential functions defensive response homeostasis insect life cycle.
Язык: Английский
Процитировано
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