Fungal secondary metabolism: regulation, function and drug discovery

Nature Reviews Microbiology, Год журнала: 2018, Номер 17(3), С. 167 - 180

Опубликована: Дек. 10, 2018

Язык: Английский

---

Aspergillus fumigatus and Aspergillosis in 2019

Clinical Microbiology Reviews, Год журнала: 2019, Номер 33(1)

Опубликована: Ноя. 12, 2019

Aspergillus fumigatus is a saprotrophic fungus; its primary habitat the soil. In ecological niche, fungus has learned how to adapt and proliferate in hostile environments. This capacity helped resist survive against human host defenses and, further, be responsible for one of most devastating lung infections terms morbidity mortality.

Язык: Английский

---

The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

Frontiers in Plant Science, Год журнала: 2022, Номер 13

Опубликована: Дек. 12, 2022

The global environment is dominated by various small exotic substances, known as secondary metabolites, produced plants and microorganisms. Plants fungi are particularly plentiful sources of these molecules, whose physiological functions, in many cases, remain a mystery. Fungal metabolites (SM) diverse group substances that exhibit wide range chemical properties generally fall into one four main family groups: Terpenoids, polyketides, non-ribosomal peptides, or combination the latter two. They incredibly varied their functions often related to increased fitness respective fungus its environment, competing with other microbes interacting plant species. Several have essential roles biological control diseases beneficial microorganisms used for crop protection biofertilization worldwide. Besides direct toxic effects against phytopathogens, natural can promote root shoot development and/or disease resistance activating host systemic defenses. ability synthesize store biologically active potent source novel compounds agriculture becoming top priority SM research. In this review, we will discuss fungal-plant antifungal role signaling molecules induced acquired activities. Additionally, fungal mimic promotion such auxins, gibberellins, abscisic acid, which modulate growth under biotic stress. Moreover, present new trend regarding phytoremediation applications using achieve sustainable food production microbial diversity an eco-friendly environment.

Язык: Английский

---

Fungal spores: Highly variable and stress-resistant vehicles for distribution and spoilage

Food Microbiology, Год журнала: 2018, Номер 81, С. 2 - 11

Опубликована: Ноя. 21, 2018

Язык: Английский

---

Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments

Nature Microbiology, Год журнала: 2021, Номер 6(8), С. 1066 - 1081

Опубликована: Июнь 28, 2021

Язык: Английский

---

Molecular regulation of fungal secondary metabolism

World Journal of Microbiology and Biotechnology, Год журнала: 2023, Номер 39(8)

Опубликована: Май 20, 2023

Язык: Английский

---

Re-Evaluating Botryosphaeriales: Ancestral State Reconstructions of Selected Characters and Evolution of Nutritional Modes

Journal of Fungi, Год журнала: 2023, Номер 9(2), С. 184 - 184

Опубликована: Янв. 29, 2023

Botryosphaeriales (Dothideomycetes, Ascomycota) occur in a wide range of habitats as endophytes, saprobes, and pathogens. The order has not been subjected to evaluation since 2019 by Phillips co-authors using phylogenetic evolutionary analyses. Subsequently, many studies introduced novel taxa into the revised several families separately. In addition, no ancestral character have conducted for this order. Therefore, study, we re-evaluated evolution taxonomic placements species based on evolution, divergence time estimation, relationships, including all that so far. Maximum likelihood, maximum parsimony, Bayesian inference analyses were combined LSU ITS sequence alignment. Ancestral state reconstruction was carried out conidial colour, septation, nutritional mode. Divergence times estimates revealed originated around 109 Mya early epoch Cretaceous period. All six evolved late period (66–100 Mya), during which Angiosperms also appeared, rapidly diversified became dominant land. Families Paleogene Neogene periods Cenozoic era. comprises Aplosporellaceae, Botryosphaeriaceae, Melanopsaceae, Phyllostictaceae, Planistromellaceae Saccharataceae. Furthermore, current study assessed two hypotheses; first one being “All endophytes then switched saprobes when their hosts died or pathogens under stress”; second hypothesis states “There is link between colour mode botryosphaerialean taxa”. pathogenic/saprobic character. However, could provide strong evidence mainly due significantly low number reporting endophytic taxa. Results showed hyaline aseptate conidia characters supported relationship pigmentation pathogenicity species.

Язык: Английский

---

The fungal spore and food spoilage

Current Opinion in Food Science, Год журнала: 2017, Номер 17, С. 68 - 74

Опубликована: Окт. 1, 2017

Язык: Английский

---

Thymol Induces Conidial Apoptosis in Aspergillus flavus via Stimulating K⁺ Eruption

Journal of Agricultural and Food Chemistry, Год журнала: 2018, Номер 66(32), С. 8530 - 8536

Опубликована: Июль 25, 2018

Aspergillus flavus is a notorious foodborne fungus, posing significant risk to humans in the form of hepatocellular carcinoma or aspergillosis. Thymol, as food preservative, could efficiently kill conidia A. flavus. However, underlying mechanisms by which thymol kills are not completely understood. With specific fluorescent dyes, we detected several apoptotic hallmarks, including chromatin condensation, phosphatidylserine externalization, DNA damage, mitochondrial depolarization, and caspase 9 activation exposed 200 μg/mL thymol, indicating that induced caspase-dependent conidial apoptosis Chemical–protein interactome (CPI) autodock analyses showed KCNAB, homologue β-subunit voltage-gated potassium channel (Kv) aldo-keto reductase, was potential target thymol. Following studies demonstrated activate reductase activity KCNAB vitro stimulate transient K+ efflux conidia, determined using Port-a-Patch. Blocking eruption 4-aminopyridine (a universal inhibitor Kv) significantly alleviate thymol-mediated apoptosis, Kv responsible for apoptosis. Taken together, our results revealed efflux-mediated pathway flavus, greatly contributed development an alternative strategy control this pathogen.

Язык: Английский

---

The most heat‐resistant conidia observed to date are formed by distinct strains of Paecilomyces variotii

Environmental Microbiology, Год журнала: 2019, Номер 22(3), С. 986 - 999

Опубликована: Авг. 24, 2019

Summary Fungi colonize habitats by means of spores. These cells are stress‐resistant compared with growing fungal cells. Fungal conidia, asexual spores, formed cosmopolitan genera like Penicillium , Aspergillus and Peacilomyces dispersed air. They present in places where food products stored as a result, they cause spoilage. Here, we determined the heterogeneity heat resistance conidia between within strains Paecilomyces variotii spoiler foods such margarine, fruit juices, canned fruits non‐carbonized sodas. Out 108 strains, 31 isolates showed conidial survival >10% after 10‐min‐heat treatment at 59°C. Three different were selected for further phenotyping. Conidia DTO 212‐C5 032‐I3 0.3% 2.6% screening respectively, while 217‐A2 was >10%. The decimal reduction times these 60°C ( D 60 value) 3.7 ± 0.08, 5.5 0.35 22.9 2.00 min respectively. Further in‐depth analysis revealed that three differences morphology, spore size distributions, compatible solute compositions growth under salt stress. most heat‐resistant reported so far. ecological consequences this resistance, including spoilage, discussed.

Язык: Английский

---