Journal of Clinical Biochemistry and Nutrition,
Год журнала:
2024,
Номер
76(2), С. 195 - 201
Опубликована: Ноя. 6, 2024
Although
we
previously
reported
that
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
has
antioxidant
properties,
its
effect
on
the
skin
remains
unclear.
This
study
aimed
to
investigate
effects
of
beverages
containing
moisture.
enrolled
220
healthy
Japanese
participants
with
dry
who
were
randomly
assigned
test
or
placebo
group
(n
=
110
each).
Each
received
either
a
beverage
for
12
weeks.
The
primary
outcome
was
stratum
corneum
water
content.
Secondary
outcomes
transdermal
loss,
number
blemishes
and
wrinkles,
blood
markers
such
as
biological
potential
diacron-reactive
oxygen
metabolites.
Visual
analog
scale
used
assess
improvement.
Stratum
content
visual
scores
differed
significantly
between
groups.
Water
increased
in
compared
at
4
8
Subjective
symptoms
improved
intake
placebo.
No
other
significant
adverse
observed.
In
conclusion,
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing
consecutive
weeks
increases
findings
could
aid
development
safe
functional
foods
enriched
this
compound.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4857 - 4857
Опубликована: Май 19, 2025
Exosomes,
nanoscale
vesicles
involved
in
intercellular
communication,
have
garnered
significant
attention
for
their
potential
drug
delivery
and
therapeutic
applications.
This
review
provides
a
comparative
analysis
of
mammalian-derived
exosomes,
particularly
milk-derived
plant-derived
exosome-like
nanoparticles
(PDENs).
It
explores
biogenesis,
bioactivities,
functional
similarities,
including
roles
cellular
immune
modulation,
disease
therapy.
While
exosomes
exhibit
promising
biocompatibility
stability
targeted
delivery,
PDENs
offer
distinct
advantages,
such
as
scalability
inherent
derived
from
plant
sources.
Despite
similarities
structure
cargo,
differ
lipid
composition
protein
profiles,
reflecting
plant-specific
functions.
Emerging
research
highlights
the
managing
inflammation,
oxidative
stress,
other
diseases,
emphasizing
utility
food
components
nanocarriers.
However,
challenges
related
to
chemical
large-scale
production
require
further
investigation.
underscores
need
advanced
studies
fully
harness
these
natural
nanocarriers
drug-delivery
systems
interventions.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12793 - 12815
Опубликована: Ноя. 1, 2024
Plant-derived
exosome-like
nanovesicles
(PELNs)
from
edible
plants,
isolated
by
ultracentrifugation,
size
exclusion
chromatography
or
other
methods,
were
proved
to
contain
a
variety
of
biologically
active
and
therapeutically
specific
components.
Recently,
investigations
in
the
field
PELN-based
biomedicine
have
been
conducted,
which
positioned
those
as
promising
tools
for
prevention
treatment
several
diseases,
with
their
natural
origin
potentially
offering
superior
biocompatibility
bioavailability.
However,
inadequate
targeting
limited
therapeutic
effects
constrain
utility
clinical
translation
PELNs.
Thus,
strategies
aiming
at
bridging
gap
engineering
PELNs
great
interest.
Those
approaches
include
membrane
hybridization,
physical
chemical
surface
functionalization
encapsulation
payloads.
Herein,
we
provide
comprehensive
overview
biogenesis
composition,
isolation
purification
methods
characterization
PELNs,
well
functions.
Current
knowledge
on
construction
biomedical
application
engineered
reviewed.
Additionally,
future
directions
perspectives
this
discussed
order
further
enrich
expand
prospects
Journal of Clinical Biochemistry and Nutrition,
Год журнала:
2024,
Номер
76(2), С. 195 - 201
Опубликована: Ноя. 6, 2024
Although
we
previously
reported
that
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
has
antioxidant
properties,
its
effect
on
the
skin
remains
unclear.
This
study
aimed
to
investigate
effects
of
beverages
containing
moisture.
enrolled
220
healthy
Japanese
participants
with
dry
who
were
randomly
assigned
test
or
placebo
group
(n
=
110
each).
Each
received
either
a
beverage
for
12
weeks.
The
primary
outcome
was
stratum
corneum
water
content.
Secondary
outcomes
transdermal
loss,
number
blemishes
and
wrinkles,
blood
markers
such
as
biological
potential
diacron-reactive
oxygen
metabolites.
Visual
analog
scale
used
assess
improvement.
Stratum
content
visual
scores
differed
significantly
between
groups.
Water
increased
in
compared
at
4
8
Subjective
symptoms
improved
intake
placebo.
No
other
significant
adverse
observed.
In
conclusion,
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing
consecutive
weeks
increases
findings
could
aid
development
safe
functional
foods
enriched
this
compound.
