Journal of Clinical Biochemistry and Nutrition,
Journal Year:
2024,
Volume and Issue:
76(2), P. 195 - 201
Published: Nov. 6, 2024
Although
we
previously
reported
that
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
has
antioxidant
properties,
its
effect
on
the
skin
remains
unclear.
This
study
aimed
to
investigate
effects
of
beverages
containing
moisture.
enrolled
220
healthy
Japanese
participants
with
dry
who
were
randomly
assigned
test
or
placebo
group
(n
=
110
each).
Each
received
either
a
beverage
for
12
weeks.
The
primary
outcome
was
stratum
corneum
water
content.
Secondary
outcomes
transdermal
loss,
number
blemishes
and
wrinkles,
blood
markers
such
as
biological
potential
diacron-reactive
oxygen
metabolites.
Visual
analog
scale
used
assess
improvement.
Stratum
content
visual
scores
differed
significantly
between
groups.
Water
increased
in
compared
at
4
8
Subjective
symptoms
improved
intake
placebo.
No
other
significant
adverse
observed.
In
conclusion,
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing
consecutive
weeks
increases
findings
could
aid
development
safe
functional
foods
enriched
this
compound.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12793 - 12815
Published: Nov. 1, 2024
Plant-derived
exosome-like
nanovesicles
(PELNs)
from
edible
plants,
isolated
by
ultracentrifugation,
size
exclusion
chromatography
or
other
methods,
were
proved
to
contain
a
variety
of
biologically
active
and
therapeutically
specific
components.
Recently,
investigations
in
the
field
PELN-based
biomedicine
have
been
conducted,
which
positioned
those
as
promising
tools
for
prevention
treatment
several
diseases,
with
their
natural
origin
potentially
offering
superior
biocompatibility
bioavailability.
However,
inadequate
targeting
limited
therapeutic
effects
constrain
utility
clinical
translation
PELNs.
Thus,
strategies
aiming
at
bridging
gap
engineering
PELNs
great
interest.
Those
approaches
include
membrane
hybridization,
physical
chemical
surface
functionalization
encapsulation
payloads.
Herein,
we
provide
comprehensive
overview
biogenesis
composition,
isolation
purification
methods
characterization
PELNs,
well
functions.
Current
knowledge
on
construction
biomedical
application
engineered
reviewed.
Additionally,
future
directions
perspectives
this
discussed
order
further
enrich
expand
prospects
Journal of Clinical Biochemistry and Nutrition,
Journal Year:
2024,
Volume and Issue:
76(2), P. 195 - 201
Published: Nov. 6, 2024
Although
we
previously
reported
that
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
has
antioxidant
properties,
its
effect
on
the
skin
remains
unclear.
This
study
aimed
to
investigate
effects
of
beverages
containing
moisture.
enrolled
220
healthy
Japanese
participants
with
dry
who
were
randomly
assigned
test
or
placebo
group
(n
=
110
each).
Each
received
either
a
beverage
for
12
weeks.
The
primary
outcome
was
stratum
corneum
water
content.
Secondary
outcomes
transdermal
loss,
number
blemishes
and
wrinkles,
blood
markers
such
as
biological
potential
diacron-reactive
oxygen
metabolites.
Visual
analog
scale
used
assess
improvement.
Stratum
content
visual
scores
differed
significantly
between
groups.
Water
increased
in
compared
at
4
8
Subjective
symptoms
improved
intake
placebo.
No
other
significant
adverse
observed.
In
conclusion,
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing
consecutive
weeks
increases
findings
could
aid
development
safe
functional
foods
enriched
this
compound.
