Polyphenols and Microbiota Modulation: Insights from Swine and Other Animal Models for Human Therapeutic Strategies
Molecules,
Год журнала:
2024,
Номер
29(24), С. 6026 - 6026
Опубликована: Дек. 20, 2024
High
consumption
of
ultra-processed
foods,
rich
in
sugar
and
unhealthy
fats,
has
been
linked
to
the
onset
numerous
chronic
diseases.
Consequently,
there
a
growing
shift
towards
fiber-rich
diet,
abundant
fruits,
vegetables,
seeds,
nuts,
enhance
longevity
quality
life.
The
primary
bioactive
components
these
plant-based
foods
are
polyphenols,
which
exert
significant
effects
on
modulating
gastrointestinal
microbiota
through
their
antioxidant
anti-inflammatory
activities.
This
modulation
preventive
neurodegenerative,
metabolic,
cardiovascular
diseases,
even
cancer.
antimicrobial
properties
polyphenols
against
pathogenic
bacteria
have
significantly
reduced
need
for
antibiotics,
thereby
lowering
risk
antibiotic
resistance.
paper
advances
field
by
offering
novel
insights
into
beneficial
both
directly
metabolites
produced
during
digestion
indirectly
changes
host’s
microbiota,
uniquely
emphasizing
swine
as
model
highly
relevant
human
health,
topic
that,
our
knowledge,
not
thoroughly
explored
previous
reviews.
review
also
addresses
aspects
related
other
animal
models
(mice,
rabbits,
rats),
humans,
providing
guidelines
future
research
benefits
polyphenol
consumption.
By
linking
agricultural
biomedical
perspectives,
it
proposes
strategies
utilizing
compounds
therapeutic
agents
veterinary
health
sciences.
Язык: Английский
Effects of Resveratrol on Intestinal Flora and Metabolism in Rats With Non‐Steroidal Anti‐Inflammatory Drug‐Induced Intestinal Injury Under Plateau Hypoxia Environment
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(5)
Опубликована: Май 1, 2025
ABSTRACT
The
plateau
hypoxic
environment
is
a
main
habitat
for
human
beings,
which
can
result
in
dysbiosis
of
the
intestinal
flora.
Non‐steroidal
anti‐inflammatory
drugs
(NSAIDs)
are
widely
used
that
cause
damage
with
long‐term
administration.
Moreover,
administration
these
may
exacerbate
damage.
This
study
aimed
to
investigate
therapeutic
effect
resveratrol
(RSV)
on
injury
induced
by
NSAIDs
rats
under
hypoxia.
Aspirin
was
as
inducer
induce
rats.
Rats
were
divided
into
seven
groups:
Ck
(vehicle
group),
HCk
(high‐altitude
control
PAsp
(plain
aspirin‐treated
HAsp
(High‐altitude
RSVL
(low‐dose
resveratrol‐treated
RSVM
(medium‐dose
and
RSVH
(high‐dose
group).
body
weight
recorded
every
7
days
during
experiment.
On
last
day
experiment,
jejunal
tissues
collected
hematoxylin
eosin
staining
(H&E),
feces
analysis
flora
metabolite
analysis.
results
demonstrated
RSV
inhibited
loss
initiated
aspirin
environment.
it
markedly
elevated
expression
levels
interleukin
(IL)‐10
superoxide
dismutase
(SOD)
while
substantially
reducing
TNF‐α,
IL‐1β,
myeloperoxidase
(MPO).
Furthermore,
16SrRNA
gene
sequence
showed
both
altered
composition
structure
rat
gut
microbiomes.
Metabolomics
metabolites
aspirin‐induced
rats,
content
2‐hydroxy‐3‐
(4‐hydroxyphenyl)
protonic
acid
3‐
[(1‐carboxyvinyl)
oxy]
benzoate
increasing
coumaryl,
3‐amino‐4
hydroxybenzoate,
L‐carnitine.
Resveratrol
alleviate
NSAID
(Aspirin)‐induced
regulating
metabolites,
best
group
(50
mg/kg).
Язык: Английский