Polyphenols and Microbiota Modulation: Insights from Swine and Other Animal Models for Human Therapeutic Strategies

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6026 - 6026

Published: Dec. 20, 2024

High consumption of ultra-processed foods, rich in sugar and unhealthy fats, has been linked to the onset numerous chronic diseases. Consequently, there a growing shift towards fiber-rich diet, abundant fruits, vegetables, seeds, nuts, enhance longevity quality life. The primary bioactive components these plant-based foods are polyphenols, which exert significant effects on modulating gastrointestinal microbiota through their antioxidant anti-inflammatory activities. This modulation preventive neurodegenerative, metabolic, cardiovascular diseases, even cancer. antimicrobial properties polyphenols against pathogenic bacteria have significantly reduced need for antibiotics, thereby lowering risk antibiotic resistance. paper advances field by offering novel insights into beneficial both directly metabolites produced during digestion indirectly changes host’s microbiota, uniquely emphasizing swine as model highly relevant human health, topic that, our knowledge, not thoroughly explored previous reviews. review also addresses aspects related other animal models (mice, rabbits, rats), humans, providing guidelines future research benefits polyphenol consumption. By linking agricultural biomedical perspectives, it proposes strategies utilizing compounds therapeutic agents veterinary health sciences.

Language: Английский

Effects of Resveratrol on Intestinal Flora and Metabolism in Rats With Non‐Steroidal Anti‐Inflammatory Drug‐Induced Intestinal Injury Under Plateau Hypoxia Environment

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

ABSTRACT The plateau hypoxic environment is a main habitat for human beings, which can result in dysbiosis of the intestinal flora. Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely used that cause damage with long‐term administration. Moreover, administration these may exacerbate damage. This study aimed to investigate therapeutic effect resveratrol (RSV) on injury induced by NSAIDs rats under hypoxia. Aspirin was as inducer induce rats. Rats were divided into seven groups: Ck (vehicle group), HCk (high‐altitude control PAsp (plain aspirin‐treated HAsp (High‐altitude RSVL (low‐dose resveratrol‐treated RSVM (medium‐dose and RSVH (high‐dose group). body weight recorded every 7 days during experiment. On last day experiment, jejunal tissues collected hematoxylin eosin staining (H&E), feces analysis flora metabolite analysis. results demonstrated RSV inhibited loss initiated aspirin environment. it markedly elevated expression levels interleukin (IL)‐10 superoxide dismutase (SOD) while substantially reducing TNF‐α, IL‐1β, myeloperoxidase (MPO). Furthermore, 16SrRNA gene sequence showed both altered composition structure rat gut microbiomes. Metabolomics metabolites aspirin‐induced rats, content 2‐hydroxy‐3‐ (4‐hydroxyphenyl) protonic acid 3‐ [(1‐carboxyvinyl) oxy] benzoate increasing coumaryl, 3‐amino‐4 hydroxybenzoate, L‐carnitine. Resveratrol alleviate NSAID (Aspirin)‐induced regulating metabolites, best group (50 mg/kg).

Language: Английский