Breast Cancer Targets and Therapy,
Год журнала:
2024,
Номер
Volume 16, С. 855 - 866
Опубликована: Дек. 1, 2024
Objective:
Triple-negative
breast
cancer
(TNBC)
lacks
effective
targeted,
endocrine
therapeutic
agents
and
the
development
of
novel
is
costly
time-consuming.
The
objective
this
study
was
to
identify
pharmaceuticals
natural
products
utilized
in
clinical
practice
that
have
potential
inhibit
expression
Cellular-myelocytomatosis
oncogene
(c-Myc),
based
on
a
review
current
literature.
aim
assess
effect
specified
drugs
c-Myc
TNBC
cells,
determine
most
potent
inhibitor,
evaluate
its
impact
cell
proliferation,
invasive
migration,
apoptosis,
as
well
estrogen
receptor
(ER),
progesterone
(PR),
human
epidermal
growth
factor
2
(HER-2)
at
both
gene
protein
levels.
Explore
for
treatment
or
adjuvant
therapy
triple-negative
cancer.
Methods:
Quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
Western
blot
were
used
quantify
Flow
cytometry
employed
measure
proliferation
while
Transwell
assay
invasion
migration.
Results:
Harmaline
emerged
strongest
significantly
decreasing
levels
cells.
It
also
inhibited
invasion,
migration
promoting
apoptosis
Additionally,
there
varying
increase
ER
PR
genes
proteins.
While
HER-2
elevated,
no
significant
change
Notably,
phosphorylated
increased.
Conclusion:
found
promote
cells
by
targeting
inhibition
c-Myc.
induced
re-expression
ER,
PR,
genes,
Keywords:
c-Myc,
harmaline,
molecular
typing,
SMYD3
(SET
and
MYND
domain-containing
3)
is
a
histone
lysine
methyltransferase
highly
expressed
in
different
types
of
cancer(s)
promising
epigenetic
target
for
developing
novel
antitumor
therapeutics.
No
selective
inhibitors
this
protein
have
been
developed
cancer
treatment.
Therefore,
the
current
study
describes
characterizing
small
molecule
ZYZ384
screened
synthesized
based
on
structure.
Virtual
screening
was
initially
used
to
identify
lead
compound
followed
up
by
modification
get
molecules.
Several
technologies
were
facilitate
about
these
molecules'
binding
affinities
inhibition
activities
with
protein;
activity
has
assessed
vitro
using
various
cell
lines.
In
addition,
tumor-bearing
nude
mice
model
established,
selected
determined
vivo.
Both
RNA-seq
chip-seq
performed
explore
mechanism.
This
work
identified
targeting
impaired
hepatocellular
carcinoma
tumor
growth
reducing
H3K4
trimethylation
Rac1
promoter
triggering
cycle
arrest
through
AKT
pathway.
Current Cancer Drug Targets,
Год журнала:
2024,
Номер
24(9), С. 930 - 940
Опубликована: Янв. 25, 2024
Small
cell
lung
cancer
(SCLC)
has
a
dismal
prognosis.
In
addition
to
the
inactivation
of
tumor
suppressors
TP53
and
RB1,
tumor-promoting
MYC
paralogs
are
frequently
overexpressed
in
this
neuroendocrine
carcinoma.
SCLC
exhibits
high
resistance
second-line
chemotherapy
all
attempts
novel
drugs
targeted
therapy
have
failed
so
far
achieve
superior
survival.
key
roles
oncogenic
process,
orchestrating
proliferation,
apoptosis,
differentiation,
metabolism.
SCLC,
MYC-L
regulate
dedifferentiation
cells
from
Type
A
(ASCL1
expression)
other
subtypes.
Targeting
suppress
growth
is
difficult
due
lack
suitable
binding
pockets
most
advanced
miniprotein
inhibitor
Omomyc
limited
efficacy.
may
be
indirectly
Danggui
Buxue
(DGBX)
decoction
is
a
classical
prescription
composed
of
Astragali
Radix
(AR)
and
Angelicae
Sinensis
(ASR),
used
to
enrich
blood,
nourish
Qi
in
Chinese
medicine,
with
the
potential
recover
energy
stimulate
metabolism.
Chronic
inflammation
risk
factor
development
inflammatory
bowel
disease
(IBD)-related
colorectal
cancer
(CRC).
More
importantly,
AR
ASR
have
anti-inflammatory
anti-cancer
activities,
as
well
prefiguring
effect
on
inflammation-cancer
transformation.
We,
therefore,
aimed
review
immunometabolism
DGBX
its
components
this
malignant
transformation,
provide
helpful
complement
manage
IBD-CRC.
The
present
study
investigates
multifaceted
roles
entire
ASR,
including
anti-inflammation
effects,
properties,
immune
regulation,
metabolic
regulation.
This
assessment
informed
by
synthesis
scholarly
literature,
more
than
two
hundred
articles
retrieved
from
PubMed,
Web
Science,
Scopus
databases
within
past
decades.
search
strategy
employed
utilized
keywords
such
"Danggui
Buxue",
"Astragali
Radix",
"Angelicae
"Inflammation",
"Metabolism",
alongside
related
synonyms,
particular
emphasis
high-quality
research
studies
yielding
significant
findings.
modulating
holds
promise
for
treatment
IBD-related
CRC.
It
particularly
relevant
given
heterogeneity
CRC
growing
trend
towards
personalized
but
precise
detailed
mechanism
necessitate
further
vivo
validation
extensive
clinical
substantiate
immunometabolic
modulation
delineate
pathways
involved.
Abstract
Inflammation
is
a
crucial
target
for
therapeutic
interventions
in
many
life‐threatening
diseases,
which
sustains
ongoing
interest
the
field
of
inflammation
biology.
Plant‐derived
natural
products,
rich
phytochemicals,
have
been
used
as
healing
agents
several
diseases
since
antiquity.
These
compounds
exhibit
antioxidant,
anti‐inflammatory,
and
immunomodulatory
properties,
well
gut
microbiota
modulation.
They
hold
substantial
potential
promising
candidates
development
novel
strategies
management
inflammation‐associated
diseases.
This
study
presents
comprehensive
overview
benefits
given
from
administrating
products
(e.g.,
phenols,
terpenes,
flavonoids,
saccharides),
with
particular
emphasis
on
vitamin
C‐rich
fruits
based
high
content
bioactive
anti‐inflammatory
properties.
Apart
acts
significant
role
modulating
activation
inflammatory
reaction.
Deviations
its
composition
associated
various
Furthermore,
advancements
machine
learning
contribute
to
enhancing
clinical
outcomes
disease
treatment.
Therefore,
this
work
provided
some
valuable
insights
elaborating
fruits,
probiotics
agents,
utilization
computer‐aided
drug
design
techniques.
Genes & Diseases,
Год журнала:
2024,
Номер
12(4), С. 101435 - 101435
Опубликована: Сен. 17, 2024
MYC
is
dysregulated
in
approximately
70%
of
human
cancers,
strongly
suggesting
its
essential
function
cancer.
regulates
many
biological
processes,
such
as
cell
cycle,
metabolism,
cellular
senescence,
apoptosis,
angiogenesis,
and
immune
escape.
plays
a
central
role
carcinogenesis
key
regulator
tumor
development
drug
resistance.
Therefore,
one
the
most
alluring
therapeutic
targets
for
developing
cancer
drugs.
Although
search
direct
inhibitors
challenging,
cannot
simply
be
assumed
to
undruggable.
Targeting
MYC-MAX
complex
has
been
an
effective
method
directly
targeting
MYC.
Alternatively,
indirect
represents
more
pragmatic
approach,
mainly
including
inhibition
transcriptional
or
translational
processes
MYC,
destabilization
protein,
blocking
genes
that
are
synthetically
lethal
with
overexpression.
In
this
review,
we
delineate
multifaceted
roles
progression,
highlighting
spectrum
strategies
therapy
target
either
indirectly.
