Novel hormone therapies for advanced prostate cancer: understanding and countering drug resistance
Journal of Pharmaceutical Analysis,
Год журнала:
2025,
Номер
unknown, С. 101232 - 101232
Опубликована: Фев. 1, 2025
Язык: Английский
Developing glycoproteomics reveals the role of posttranslational glycosylation in the physiological and pathological processes of male reproduction
iMetaOmics.,
Год журнала:
2024,
Номер
1(1)
Опубликована: Июль 1, 2024
Abstract
Glycosylation
plays
a
pivotal
role
in
the
physiological
and
pathological
processes
of
male
reproduction.
It
impacts
thousands
proteins
is
actively
ongoing
through
all
stages
reproduction,
including
spermatogenesis,
maturation,
capacitation,
fertilization.
However,
our
grasp
on
glycosylation
within
reproductive
remains
limited,
largely
due
to
technical
hurdles.
Recent
advancements
have
seen
mapping
glycoproteome
human
semen,
utilizing
cutting‐edge
glycoproteomic
technologies.
This
breakthrough
lays
groundwork
for
in‐depth
research
into
influence
system
related
disorders.
Nevertheless,
field
faces
numerous
challenges
that
necessitate
further
methodologies.
In
this
analysis,
we
evaluated
potential
applications
advanced
techniques
study
reproduction
summarized
detailed
profiling
semen
glycome
glycoproteome.
Our
current
understanding
glycosylation's
alongside
recent
progress
glycoproteomics
may
equip
biologists
with
comprehensive
insight.
Furthermore,
analysis
brought
together
findings
abnormal
its
link
disorders
view
glycomics
glycoproteomics.
can
facilitate
clinical
application
glyco‐related
biomarkers
targets
treatment
infertility.
Язык: Английский
Triple role of exosomes in lung transplantation
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 11, 2025
Exosomes
are
tiny
vesicles
secreted
by
the
vast
majority
of
cells
and
play
an
important
role
in
physiological
as
well
pathological
processes
body.
Circulating
exosomes
Lung
Transplant
Recipients
(LTxR)
undergoing
rejection
contain
mismatched
Human
Leukocyte
Antigens
(HLA)
lung-associated
autoantigens
(e.g.,
K-alpha1
microtubule
protein
collagen
V),
which
may
induce
autoantibodies,
circulating
trigger
immune
response
that
results
lung
transplant
recipient.
This
article
discusses
transplantation
from
three
perspectives:
a
biomarker
for
after
transplantation;
mechanism
exosome-mediated
activation
response;
potential
therapeutic
strategy.
Язык: Английский
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer
Clinical Proteomics,
Год журнала:
2025,
Номер
22(1)
Опубликована: Апрель 15, 2025
Exosomes
play
important
role
in
biological
functions,
including
both
normal
and
disease
process.
Multiple
cell
types
can
secret
exosomes,
which
act
as
message
carriers.
Increased
evidences
reveal
that
exosomes
are
promising
diagnosis
biomarkers
malignant
tumors.
In
this
study,
we
enrolled
78
participants,
20
lung
adenocarcinoma
(LUAD),
18
squamous
carcinoma
(LUSC),
benign
diseases
(LUBN)
healthy
controls
(NL)
performed
parallel
reaction-monitoring
(PRM)-mass
spectrometry
to
screening
the
proteomic
variation
by
label
free
analysis
from
all
groups,
has
been
widely
used
quantify
detect
target
proteins.
Total
14
protein
were
identified
candidate
biomarkers,
complement
components
C9,
apolipoprotein
B
(APOB),
filamin
A
(FLNA),
guanine
nucleotide
binding
G
subunit
2
(GNB2),
fermitin
family
homolog
3
(FERMT3)
showed
significantly
differentiation
total
cancer
(LUAD
LUSC
together),
then
obtained
combination
of
5
proteins
area
under
curve
(AUC),
sensitivity
(SN)
specificity
(SP)
63.0%,
65.0%,
75.0%,
respectively,
comparison
NL
group.
And
LUAD
panel,
peroxiredoxin
6
(PRDX6),
integrin
alpha-IIb
(ITGA2B)
hemoglobin
delta
(HBD)
revealed
AUC
was
95.0%,
SN
90.0%
SP
95.0%
controls.
analysis,
fibronectin
1
(FN1),
pregnancy
zone
(PZP)
C1q
tumor
necrosis
factor
related
(C1QTNF3)
88.1%,
100%
paralleled
with
Finally
FLNA,
PZP
overexpressed
H1299
A549
lines
results
indicated
C9
acted
oncogenic
increasing
proliferation,
migration
invasion
cells,
while
FLNA
played
tumor-suppression
inhibition
functions
cells.
Taken
together,
our
study
multiple
exosomal
could
be
applied
cancer.
Язык: Английский
Emerging Combination of Hydrogel and Electrochemical Biosensors
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Electrochemical
sensors
are
among
the
most
promising
technologies
for
biomarker
research,
with
outstanding
sensitivity,
selectivity,
and
rapid
response
capabilities
that
make
them
important
in
medical
diagnostics
prognosis.
Recently,
hydrogels
have
gained
attention
domain
of
electrochemical
biosensors
because
their
superior
biocompatibility,
excellent
adhesion,
ability
to
form
conformal
contact
diverse
surfaces.
These
features
provide
distinct
advantages,
particularly
advancement
wearable
biosensors.
This
review
examines
contemporary
utilization
sensing,
explores
strategies
optimization
prospective
development
trajectories,
highlights
distinctive
advantages.
The
objective
is
an
exhaustive
overview
foundational
principles
sensing
systems,
analyze
compatibility
hydrogel
properties
methodologies,
propose
potential
healthcare
applications
further
illustrate
applicability.
Despite
significant
advances
hydrogel‐based
biosensors,
challenges
persist,
such
as
improving
material
fatigue
resistance,
interfacial
maintaining
balanced
water
content
across
various
environments.
Overall,
immense
flexible
exciting
opportunities.
However,
resolving
current
obstacles
will
necessitate
additional
research
efforts.
Язык: Английский
Profiling Plasma Extracellular Vesicle Metabotypes and miRNAs: An Unobserved Clue for Predicting Relapse in Patients with Early-Stage NSCLC
Cancers,
Год журнала:
2024,
Номер
16(22), С. 3729 - 3729
Опубликована: Ноя. 5, 2024
Lung
cancer,
the
second
most
prevalent
cancer
globally,
poses
significant
challenges
in
early
detection
and
prognostic
assessment.
Despite
advancements
targeted
therapies
immunotherapy,
timely
identification
of
relapse
remains
elusive.
Blood-based
liquid
biopsy
biomarkers,
including
circulating
tumor
cells
(CTCs),
cell-free
DNA
(cfDNA),
(ctDNA),
circulating-free
RNAs
(cfRNAs),
extracellular
vesicles
(EVs)/exosomes,
offer
promise
for
non-invasive
monitoring.
Язык: Английский