Биохимия,
Год журнала:
2023,
Номер
88(1), С. 47 - 67
Опубликована: Янв. 15, 2023
The
plasticity
of
tumor
cells
due
to
the
multiplicity
molecular
regulation
allows
evade
cytocidal
effects
chemo-
and/or
radiation
therapy.
Metabolic
adaptation
survived
is
based
on
transcriptional
reprogramming.
Because
similarities
with
natural
cell
aging,
specific
features
comprise
phenotype
therapy
induced
senescence.
Most
importantly,
senescent
differ
from
parental
since
they
become
less
responsive
drugs
and
form
aggressive
progeny.
importance
problem
explained
by
general
biological
significance
reprogramming
as
a
mechanism
stress,
emerging
perspective
its
pharmacological
targeting.
We
analyze
mechanisms
senescence,
well
new
drug
combinations
prevent
this
clinically
unfavorable
phenomenon.
Cells,
Год журнала:
2024,
Номер
13(13), С. 1081 - 1081
Опубликована: Июнь 22, 2024
Successful
pregnancy
depends
on
precise
molecular
regulation
of
uterine
physiology,
especially
during
the
menstrual
cycle.
Deregulated
oxidative
stress
(OS),
often
influenced
by
inflammatory
changes
but
also
environmental
factors,
represents
a
constant
threat
to
this
delicate
balance.
Oxidative
induces
reciprocally
regulated
nuclear
factor
erythroid
2-related
2/peroxisome
proliferator-activated
receptor-gamma
(Nrf2/PPARγ)
pathway.
However,
increased
PPARγ
activity
appears
be
double-edged
sword
in
endometrial
physiology.
Activated
attenuates
inflammation
and
OS
restore
redox
homeostasis.
it
interferes
with
physiological
processes
cycle,
such
as
hormonal
signaling
angiogenesis.
This
review
provides
an
elucidation
mechanisms
that
support
interplay
between
OS.
Additionally,
offers
fresh
perspectives
Nrf2/PPARγ
pathway
concerning
receptivity
its
potential
implications
for
infertility.
Molecules and Cells,
Год журнала:
2023,
Номер
46(11), С. 664 - 671
Опубликована: Ноя. 1, 2023
The
proper
maintenance
of
mRNA
quality
that
is
regulated
by
diverse
surveillance
pathways
essential
for
cellular
homeostasis
and
highly
conserved
among
eukaryotes.Here,
we
review
findings
regarding
the
role
control
in
aging
longevity
Caenorhabditis
elegans,
an
outstanding
model
research.We
discuss
recently
discovered
functions
regulation
nonsense-mediated
decay,
ribosome-associated
control,
splicing
C.
elegans.We
describe
how
contributes
to
conferred
various
regimens,
including
inhibition
insulin/insulin-like
growth
factor
1
(IGF-1)
signaling,
dietary
restriction,
reduced
mechanistic
target
rapamycin
signaling.This
provides
valuable
information
relationship
between
which
may
lead
insights
into
healthy
complex
organisms,
humans.
Molecules and Cells,
Год журнала:
2024,
Номер
47(9), С. 100102 - 100102
Опубликована: Июль 23, 2024
Cellular
senescence
is
a
crucial
biological
process
associated
with
organismal
aging
and
many
chronic
diseases.
Here,
we
present
brief
guide
to
mammalian
assays,
including
the
measurement
of
cell
cycle
arrest,
change
in
cellular
morphology,
senescence-associated
β-galactosidase
(SA-β-gal)
staining,
expression
secretory
phenotype
(SASP).
This
work
will
be
useful
for
biologists
minimum
expertise
assays.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 28, 2023
Background:
Colon
adenocarcinoma
(COAD)
is
a
heterogeneous
tumor
and
senescence
crucial
in
the
occurrence
of
cancer.
This
study
aimed
to
identify
senescence-based
subtypes
construct
prognostic
signature
predict
prognosis
guide
immunotherapy
or
chemotherapy
decisions
for
COAD
patients.
Methods:
Based
on
single-cell
RNA
sequencing
(scRNA-seq)
data
13
samples
from
Gene
Expression
Omnibus
(GEO)
database,
we
assessed
cellular
characteristics.
Transcriptome
data,
copy
number
variations
(CNVs)
single
nucleotide
(SNVs)
were
obtained
The
Cancer
Genome
Atlas
(TCGA)
database.
GSE39582
GSE17537
used
validation.
Senescence
identified
using
unsupervised
consensus
clustering
analysis,
was
developed
univariate
Cox
analysis
least
absolute
shrinkage
selection
operator
(LASSO).
Response
risk
groups
predicted
half-maximal
inhibitory
concentration
(IC50)
values.
We
further
analyzed
relationship
between
gene
expression
methylation
level.
prediction
performance
by
nomogram.
Results:
Senescence-related
pathways
highly
enriched
malignant
cells
bulk
RNA-seq
verified
senescence.
Three
identified,
which
patients
clust3
had
poorest
higher
T
stage,
accompanied
with
mutation
burden
(TMB)
mutations,
activated
inflammatory
response,
more
immune
cell
infiltration,
escape
tendency.
A
11
genes
(MFNG,
GPRC5B,
TNNT1,
CCL22,
NOXA1,
PABPC1L,
PCOLCE2,
MID2,
CPA3,
HSPA1A,
CALB1)
established,
accurately
lower
high
Its
robustness
validated
external
cohort.
Low
sensitive
small
molecule
drugs
including
Erlotinib,
Sunitinib,
MG-132,
CGP-082996,
AZ628,
Sorafenib,
VX-680,
Z-LLNle-CHO.
Risk
score
an
independent
factor
nomogram
confirmed
its
reliability.
Four
(CALB1,
TNNT1)
significant
positive
correlation
their
level,
while
six
(CCL22,
MFNG,
PCOLCE2)
negatively
correlated
Conclusion:
provides
novel
understanding
heterogeneity
perspective
senescence,
develops
signatures
COAD.
Molecules and Cells,
Год журнала:
2024,
Номер
47(4), С. 100047 - 100047
Опубликована: Март 18, 2024
Aging
is
accompanied
by
the
gradual
deregulation
of
transcriptome.
However,
whether
age-dependent
changes
in
transcriptome
are
evolutionarily
conserved
or
diverged
remains
largely
unexplored.
Here,
we
performed
a
meta-analysis
examining
using
publicly
available
datasets
eleven
representative
metazoans,
ranging
from
Caenorhabditis
elegans
to
human.
To
identify
transcriptomic
associated
with
aging,
analyzed
various
aspects
transcriptome,
including
genome
composition,
RNA
processing,
and
functional
consequences.
The
use
introns
novel
splice
sites
tended
increase
age,
particularly
brain.
In
addition,
our
analysis
suggests
that
accumulation
premature
termination
codon-containing
transcripts
common
feature
aging
across
multiple
animal
species.
Using
C.
as
test
model,
showed
several
splicing
factors
age-dependently
downregulated
were
required
maintain
normal
lifespan.
Thus,
aberrant
processing
appears
be
short
lifespan
