Evaluation of serum levels of homocysteine and C-reactive protein in patients with ischemic stroke DOI Creative Commons

Liu Yang,

Bing Xu

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(7), С. 56 - 62

Опубликована: Июль 31, 2022

Stroke is the third most common cause of death in world. Plasma homocysteine an emerging risk factor for stroke. Also, previous studies have shown that serum levels C-reactive protein (CRP) are significantly associated with mortality and function patients ischemic In present study, we examined CRP This descriptive-analytical study was performed on 100 Blood samples were taken first 24 hours a stroke to measure CRP. The Axis ELISA kit (IBL, Germany) measured plasma homocysteine. Doppler ultrasound cerebral arteries also five days. Independent chi-square, ANOVA, t-tests used analyze data. It observed NIHSS mean not different from age (P = 0.876). Significant relationship between level HTN (p 0.070), HLP 0.103), DM 0.999), history CVA 0.946), MI 0.262), smoking 0.109), number factors 0.383). Data analysis showed hypertension 0.021). There significant location internal carotid artery stenosis 0.015) middle 0.006). general, this increased high range has frequency. more whose high. finding suggests abnormal may be some arteries.

Язык: Английский

Determining the frequency of Streptococcus pneumoniae carriers and its microbial resistance in children DOI Creative Commons

Langhuan Lei,

Xingyong Wang

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(2), С. 203 - 207

Опубликована: Фев. 28, 2022

Streptococcus pneumoniae is a common cause of bacterial infections the respiratory system, middle ear infection, bacteremia, meningitis, and pneumonia, especially in children. Due to lack information about frequency resistance antibiotics, present study was performed determine carriers its microbial For this purpose, current descriptive cross-sectional conducted from November March 2020 on 554 children aged 2-12 years kindergartens schools. This collected samples with sterile swab nasopharyngeal region, transported them laboratory by transport medium, then cultured an agar culture medium. After isolation, confirmatory tests antibiotic susceptibility were performed. The results analyzed using SPSS16 software interpreted according Mann Whitney U Chi-Square Tests. pneumoniaewas found 15% samples, isolates antibiotics azithromycin, amoxicillin, rifampicin, amoxicillin-clavulanic acid, trimethoprim/Sulfamethoxazole, ceftriaxone 63.9%, 56.6%, 41%, 37.3%, 3.6%, respectively. Also, 31.1% not resistant any antibiotics. According results, excessive use has led high amoxicillin/clavulanic which indicates increased risk refractory infectious diseases. reason, it necessary adequately educate physicians general public overuse

Язык: Английский

Процитировано

2
Comparison of pulpal vitalization and root canal therapy in symptomatic immature permanent molars DOI Creative Commons

Jianxia Guang,

Junke Li,

Shiling Guo

и другие.

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(2), С. 178 - 182

Опубликована: Фев. 28, 2022

Endodontic treatment of immature permanent teeth has various problems. Today, the primary goal in such is to preserve life pulp so that roots can develop entirely and naturally. If vital therapy treat these teeth, will be simpler less expensive. Therefore, this study compared (including calcium-enriched mixture (CEM) cement MTA methods) root canal (RCT) symptomatic molars. Also, expression TLR-2 TLR-4 was evaluated gingival tissue patients for further evaluation. In clinical trial study, 615 randomly received three treatments: pulpotomy with CEM (205 cases), (207 (203 cases). The presence periapical lesion radiographically at three-time points: start, six months, 12 months after treatment. also by Real-time PCR technique. one-year follow-up index shows six-month groups MTA, CEM, RCT equals 14 cases (8%), 7 (4%), 40 (22%). (7%), 9 (5%), 33 (18%), respectively. gene results showed no statistical difference between (CEM, RCT). Still, one year treatment, there a statistically different (CEM MTA) (P<0.05). terms before general, using two biomaterials, more successful than

Язык: Английский

Процитировано

2
Evaluating serum level of granulocyte, macrophage and granulocyte-macrophage colony-stimulating factors in patients with breast tumor DOI Creative Commons

Xin Liu,

Zhiyuan Xu

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(5), С. 146 - 152

Опубликована: Май 31, 2022

Colony-stimulating factors (CSFs) are glycoproteins that stimulate the proliferation and differentiation of hematopoietic progenitor cells in bone marrow. But numerous studies have shown these can non-hematopoietic cells, including cancer cells. Hence, this study, Macrophage-CSF (M-CSF), macrophage-granulocyte CSF (GM-CSF), granulocyte-SCF (G-CSF) were evaluated serum patients with breast tumors their relationship pathological paraclinical parameters disease. In 62 who had not received any treatment 54 healthy women matched age group patient included as a control group. After obtaining informed consent, 5ml peripheral blood was taken from both groups, isolated. Serum levels studied cytokines measured by cytokine-bead array method. Data analyzed using SPSS18 software significance level 0.05. The mean M-CSF, G-CSF, GM-CSF growth 63.48, 16.13, 6.11pg/ml, respectively. Although statistical analysis did show significant difference between groups (p <0.05), further showed increasing disease stages I to III, significantly. Decreases = 0.016). Overall, results study indicated antitumor role cancer. However, confirmation requires more complete larger sample sizes.

Язык: Английский

Процитировано

2
Expression of LATS1 in head and neck squamous cell carcinoma and its effect on tumor cell proliferation and invasion DOI Creative Commons

Wuhanhui Wan,

Baochun Sun,

Shuzhi Yang

и другие.

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(5), С. 135 - 140

Опубликована: Май 31, 2022

Nowadays, the incidence and mortality of head neck tumors are gradually increasing. Head malignant (such as laryngeal cancer, hypopharyngeal oral nasopharyngeal oropharyngeal other malignancies) more common among systemic tumors. The most pathological tumor type is squamous cell carcinoma, accounting for about 90%. In this study, immunohistochemical methods were used to collect normal epithelial tissues neck, atypical hyperplasia tissues, carcinomas on a tissue chip detection. recombinant LATS1 overexpression plasmid was prepared transferred into B88 cells. Western blotting, MTT, Transwell chamber detect effects proliferation, migration, overexpression. experimental results showed that in expression protein decreased from 59.3% 11.3%. At same time, inhibited invasion cells also epithelium- Interstitial transformation exerts its suppressor effect, indicating may play effect gene. An in-depth study role mechanism occurrence carcinoma provide new opportunities treatment future.

Язык: Английский

Процитировано

2
Evaluation of serum levels of homocysteine and C-reactive protein in patients with ischemic stroke DOI Creative Commons

Liu Yang,

Bing Xu

Cellular and Molecular Biology, Год журнала: 2022, Номер 68(7), С. 56 - 62

Опубликована: Июль 31, 2022

Stroke is the third most common cause of death in world. Plasma homocysteine an emerging risk factor for stroke. Also, previous studies have shown that serum levels C-reactive protein (CRP) are significantly associated with mortality and function patients ischemic In present study, we examined CRP This descriptive-analytical study was performed on 100 Blood samples were taken first 24 hours a stroke to measure CRP. The Axis ELISA kit (IBL, Germany) measured plasma homocysteine. Doppler ultrasound cerebral arteries also five days. Independent chi-square, ANOVA, t-tests used analyze data. It observed NIHSS mean not different from age (P = 0.876). Significant relationship between level HTN (p 0.070), HLP 0.103), DM 0.999), history CVA 0.946), MI 0.262), smoking 0.109), number factors 0.383). Data analysis showed hypertension 0.021). There significant location internal carotid artery stenosis 0.015) middle 0.006). general, this increased high range has frequency. more whose high. finding suggests abnormal may be some arteries.

Язык: Английский

Процитировано

2