Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 26, 2024
Cancer
remains
a
global
health
challenge,
necessitating
continuous
advancements
in
diagnostic
and
treatment
strategies.
This
review
focuses
on
the
utility
of
non-invasive
biomarkers
cancer
diagnosis
treatment,
their
role
early
detection,
disease
monitoring,
personalized
therapeutic
interventions.
Through
systematic
literature,
we
identified
45
relevant
studies
that
highlight
potential
these
across
various
types,
such
as
breast,
prostate,
lung,
colorectal
cancers.
The
discussed
include
liquid
biopsies,
epigenetic
markers,
non-coding
RNAs,
exosomal
cargo,
metabolites.
Notably,
particularly
those
based
circulating
tumour
DNA
(ctDNA),
have
emerged
most
promising
method
for
early,
detection
due
to
ability
provide
comprehensive
genetic
information
from
easily
accessible
blood
samples.
demonstrates
how
can
facilitate
accurate
subtyping,
tailored
strategies,
thereby
improving
patient
outcomes.
It
underscores
transformative
oncology,
highlighting
application
enhancing
survival
rates,
precision
care.
Язык: Английский
Updates on SPOP Gene Mutations in Prostate Cancer and Computational Insights From TCGA cBioPortal Database
Scientifica,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Speckle‐type
pox
virus
and
zinc
finger
protein
(SPOP)
has
emerged
as
a
key
focus
in
prostate
cancer
research
due
to
its
critical
role
regulating
the
androgen
receptor
(AR)
signaling
pathway.
This
review
aims
comprehensively
summarize
current
knowledge
on
SPOP
gene
mutations
cancer,
emphasizing
their
importance
disease
characterization
identification
of
therapeutic
targets.
A
systematic
literature
search
was
conducted
across
multiple
databases,
including
PubMed,
Web
Science,
Scopus,
Google
Scholar.
In
addition,
this
study
uses
computational
approaches
data
from
TCGA
cBioPortal
database
explore
landscape
cancer.
After
screening
682
articles
following
selection
steps,
56
high‐quality
were
included.
Computational
analysis
revealed
mutation
prevalence
5%‐6%,
along
with
significant
alterations
AR
epigenetic
regulation.
disrupt
substrate
recognition,
leading
dysregulation
downstream
pathways
such
chromatin
remodeling.
Notably,
SPOP‐mutant
cancers
are
mutually
exclusive
TMPRSS2‐ERG
fusions
enriched
for
Wnt
pathway
alterations.
Patients
demonstrate
prolonged
responses
deprivation
therapy
(ADT),
although
concurrent
TP53
or
DNA
repair
genes
negatively
impact
outcomes.
While
prognostic
significance
continues
evolve,
highlights
potential
The
clinical
implications
substantial,
they
linked
variations
treatment
response
progression,
thus
serving
valuable
biomarkers
risk
stratification
prognosis.
Язык: Английский
The role of SRC-3 in prostate cancer progression and implications for therapeutic targeting: A systematic review
Journal of Pharmacy & Pharmacognosy Research,
Год журнала:
2024,
Номер
12(5), С. 994 - 1007
Опубликована: Май 23, 2024
Context:
Prostate
cancer
remains
a
significant
global
health
concern,
and
understanding
the
molecular
drivers
of
this
disease
is
crucial
for
developing
effective
diagnostic
therapeutic
strategies.
Steroid
receptor
coactivator-3
(SRC-3),
member
SRC
family,
has
emerged
as
key
player
in
prostate
pathogenesis.
Aims:
To
examine
role
SRC-3
cancer,
encompassing
mechanisms,
clinical
implications,
opportunities.
Methods:
A
systematic
literature
search
following
PRISMA
guidelines
was
conducted
PubMed,
PMC,
other
relevant
databases
to
identify
studies
that
investigate
cancer.
Results:
785
articles
were
retrieved
from
using
specific
keywords
MeSH
terms
related
Cancer.
After
removing
461
duplicates,
260
excluded
based
on
title
abstract
review.
Subsequently,
comprehensive
screening
by
three
researchers
resulted
47
Evidence
suggests
expression
correlates
with
aggressiveness,
recurrence,
poor
patient
outcomes.
Its
potential
biomarker
target
if
explored,
offers
insights
into
personalized
medicine
approaches.
Conclusions:
plays
pivotal
influencing
progression
Understanding
intricacies
new
opportunities
precision
innovative
This
review
provides
overview
SRC-3's
involvement
emphasizing
its
relevance
target,
ultimately
contributing
improved
care
era
oncology.
Язык: Английский
The Association of Steroid 5-alpha Reductase Type-II Gene Polymorphisms (A49T and V89L) with Prostate Cancer Risk in African Population: A Systematic Review and Meta-analysis
Scientific African,
Год журнала:
2024,
Номер
26, С. e02370 - e02370
Опубликована: Сен. 15, 2024
Язык: Английский