Emerging biomarkers for non-invasive diagnosis and treatment of cancer: a systematic review

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 26, 2024

Cancer remains a global health challenge, necessitating continuous advancements in diagnostic and treatment strategies. This review focuses on the utility of non-invasive biomarkers cancer diagnosis treatment, their role early detection, disease monitoring, personalized therapeutic interventions. Through systematic literature, we identified 45 relevant studies that highlight potential these across various types, such as breast, prostate, lung, colorectal cancers. The discussed include liquid biopsies, epigenetic markers, non-coding RNAs, exosomal cargo, metabolites. Notably, particularly those based circulating tumour DNA (ctDNA), have emerged most promising method for early, detection due to ability provide comprehensive genetic information from easily accessible blood samples. demonstrates how can facilitate accurate subtyping, tailored strategies, thereby improving patient outcomes. It underscores transformative oncology, highlighting application enhancing survival rates, precision care.

Language: Английский

The role of SRC-3 in prostate cancer progression and implications for therapeutic targeting: A systematic review

Journal of Pharmacy & Pharmacognosy Research, Journal Year: 2024, Volume and Issue: 12(5), P. 994 - 1007

Published: May 23, 2024

Context: Prostate cancer remains a significant global health concern, and understanding the molecular drivers of this disease is crucial for developing effective diagnostic therapeutic strategies. Steroid receptor coactivator-3 (SRC-3), member SRC family, has emerged as key player in prostate pathogenesis. Aims: To examine role SRC-3 cancer, encompassing mechanisms, clinical implications, opportunities. Methods: A systematic literature search following PRISMA guidelines was conducted PubMed, PMC, other relevant databases to identify studies that investigate cancer. Results: 785 articles were retrieved from using specific keywords MeSH terms related Cancer. After removing 461 duplicates, 260 excluded based on title abstract review. Subsequently, comprehensive screening by three researchers resulted 47 Evidence suggests expression correlates with aggressiveness, recurrence, poor patient outcomes. Its potential biomarker target if explored, offers insights into personalized medicine approaches. Conclusions: plays pivotal influencing progression Understanding intricacies new opportunities precision innovative This review provides overview SRC-3's involvement emphasizing its relevance target, ultimately contributing improved care era oncology.

Language: Английский

The Association of Steroid 5-alpha Reductase Type-II Gene Polymorphisms (A49T and V89L) with Prostate Cancer Risk in African Population: A Systematic Review and Meta-analysis

Scientific African, Journal Year: 2024, Volume and Issue: 26, P. e02370 - e02370

Published: Sept. 15, 2024

Language: Английский