Russian Bulletin of Obstetrician-Gynecologist, Год журнала: 2024, Номер 24(2), С. 30 - 30
Опубликована: Янв. 1, 2024
Язык: Английский
Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066
Опубликована: Апрель 11, 2023
Язык: Английский
Процитировано
205
Journal of Ovarian Research, Год журнала: 2024, Номер 17(1)
Опубликована: Май 31, 2024
Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.
Язык: Английский
Процитировано
15
Animal Reproduction Science, Год журнала: 2024, Номер 264, С. 107458 - 107458
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
10
Human Reproduction Update, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Ovarian aging occurs earlier than the of many other organs and has a lasting impact on women's overall health well-being. However, effective interventions to slow ovarian remain limited, primarily due an incomplete understanding underlying molecular mechanisms drug targets. Recent advances in omics data resources, combined with innovative computational tools, are offering deeper insight into complexities aging, paving way for new opportunities discovery development. This review aims synthesize expanding multi-omics data, spanning genome, transcriptome, proteome, metabolome, microbiome, related from both tissue-level single-cell perspectives. We will specially explore how analysis these emerging datasets can be leveraged identify novel targets guide therapeutic strategies slowing reversing aging. conducted comprehensive literature search PubMed database using range relevant keywords: age at natural menopause, premature insufficiency (POI), diminished reserve (DOR), genomics, transcriptomics, epigenomics, DNA methylation, RNA modification, histone proteomics, metabolomics, lipidomics, single-cell, genome-wide association studies (GWAS), whole-exome sequencing, phenome-wide (PheWAS), Mendelian randomization (MR), epigenetic target, machine learning, artificial intelligence (AI), deep multi-omics. The was restricted English-language articles published up September 2024. Multi-omics have uncovered key driving including damage repair deficiencies, inflammatory immune responses, mitochondrial dysfunction, cell death. By integrating researchers critical regulatory factors across various biological levels, leading potential Notable examples include genetic such as BRCA2 TERT, like Tet FTO, metabolic sirtuins CD38+, protein BIN2 PDGF-BB, transcription FOXP1. advent cutting-edge technologies, especially technologies spatial provided valuable insights guiding treatment decisions become powerful tool aimed mitigating or As technology advances, integration AI models holds more accurately predict candidate convergence offers promising avenues personalized medicine precision therapies, tailored Not applicable.
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2025, Номер 13(3), С. 730 - 730
Опубликована: Март 17, 2025
Background: Epigenetic modifications have an important role in controlling ovarian function, modulating response and implantation success Assisted Reproductive Technologies (ART). The alterations, such as DNA methylation non-coding RNA control, been identified key variables regulating physiology reproductive outcomes. This systematic review investigates the significance of epigenetic pathways with emphasis on their effect ART rates. Methods: A thorough search PubMed, Scopus, EMBASE databases was performed to find articles published between 2015 2024 that investigated connection changes function patients. Studies examined miRNA expression, methylation, histone follicular fluid, granulosa cells, embryos were included. study followed PRISMA recommendations guarantee scientific rigor repeatability. data combined into a markers linked aging, reserve, success. Results: total 15 studies satisfied inclusion criteria, substantial relationships found distinct function. Changes expression patterns fluid cells associated oocyte maturation, potential. Women low reserve polycystic ovary syndrome (PCOS) different patterns. MiR-27a-3p miR-15a-5p shown be involved cell malfunction poor response, whereas global hypomethylation aging results. Conclusions: alterations affect via control hormone signaling, development, Further is needed determine practical applicability biomarkers predicting effectiveness enhancing patient treatment procedures.
Язык: Английский
Процитировано
1
Protein & Cell, Год журнала: 2023, Номер 15(5), С. 364 - 384
Опубликована: Дек. 21, 2023
The ovary is indispensable for female reproduction, and its age-dependent functional decline the primary cause of infertility. However, molecular basis ovarian aging in higher vertebrates remains poorly understood. Herein, we apply spatiotemporal transcriptomics to benchmark architecture organization as well cellular determinants young primate ovaries compare these aged ovaries. From a global view, somatic cells within non-follicle region undergo more pronounced transcriptional fluctuation relative those follicle region, likely constituting hostile microenvironment that facilitates aging. Further, uncovered inflammation, senescent-associated secretory phenotype, senescence, fibrosis are contributors (PCOA). Of note, identified spatial co-localization between PCOA-featured spot an unappreciated MT2 (Metallothionein 2) highly expressing (MT2high) characterized by high levels potentially serving hotspot ovary. Moreover, with advanced age, subpopulation MT2high accumulates, disseminating amplifying senescent signal outward. Our study establishes first transcriptomic atlas, advancing our understanding mechanistic underpinning unraveling potential biomarkers therapeutic targets age-associated human disorders.
Язык: Английский
Процитировано
19
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13144 - 13144
Опубликована: Дек. 6, 2024
The efficacy of assisted reproductive technologies (ARTs) in older women remains constrained, largely due to an incomplete understanding the underlying pathophysiology. This review aims consolidate current knowledge on age-associated mitochondrial alterations and their implications for ovarian aging, with emphasis causes DNA (mtDNA) mutations, repair mechanisms, future therapeutic directions. Relevant articles published up 30 September 2024 were identified through a systematic search electronic databases. free radical theory proposes that reactive oxygen species (ROS) inflict damage mtDNA impair function essential ATP generation oocytes. Oocytes face prolonged pressure persisting five decades. MtDNA exhibits limited capacity double-strand break repair, heavily depending poly ADP-ribose polymerase 1 (PARP1)-mediated single-strand breaks. process depletes nicotinamide adenine dinucleotide (NAD⁺) ATP, creating detrimental cycle where continued further compromises oocyte functionality. Interventions interrupt this destructive may offer preventive benefits. In conclusion, cumulative burden mutations demands can lead depletion elevate risk aneuploidy, ultimately contributing ART failure women.
Язык: Английский
Процитировано
9
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4680 - 4680
Опубликована: Апрель 25, 2024
The decline in female fecundity is linked to advancing chronological age. ovarian reserve diminishes quantity and quality as women age, impacting reproductive efficiency the aging process rest of body. NAD+ an essential coenzyme cellular energy production, metabolism, cell signaling, survival. It involved various age-related conditions. Hallmarks associated with aging, diseases, metabolic dysfunctions can significantly affect fertility by disturbing delicate relationship between metabolism reproduction. Enzymes such sirtuins, PARPs, CD38 play roles biology, which actively consume their enzymatic activities. In recent years, has gained much attention for its role diseases like cancer, Alzheimer’s, cardiovascular neurodegenerative disorders, highlighting involvement pathophysiological processes. However, impact on reproduction not well understood. This review aims bridge this knowledge gap comprehensively exploring complex interplay biology providing valuable information that could help develop plans improve women’s health prevent issues.
Язык: Английский
Процитировано
4
Russian Bulletin of Obstetrician-Gynecologist, Год журнала: 2025, Номер 25(1), С. 44 - 44
Опубликована: Фев. 20, 2025
Objective. In infertile women with and without ovarian endometriosis, according to preimplantation genetic testing for aneuploidy, the ploidic status of embryos generated from mature oocytes (MII oocytes) a visually detectable division spindle should be clarified. Material methods. Using polarizing optical system OCTAX PolarAID, state was studied in 345 younger than 36 years healthy gonads (control group) 219 same age suffering endometriosis (main group). The influence presence/absence MII on frequency their correct fertilization, blastulation resulting evaluated. Preimplantation aneuploidy performed by Next Generation Sequencing (NGS). Results. cohort blastocysts that were obtained an unvisualized fission spindle, embryonic 2—3 times higher among normal state. This pattern reliable manifested itself extent endometriosis. Conclusion. When performing embryological stage IVF programs gonads, it is advisable clarify, using polarization microscopy, presence all isolated adult subsequently check pre-implantation testing, eggs undefined spindle.
Язык: Английский
Процитировано
0
Life, Год журнала: 2024, Номер 14(5), С. 541 - 541
Опубликована: Апрель 24, 2024
The aim of this study was to investigate the molecular composition follicular fluid (FF) extracellular vesicles (EVs) in women different reproductive ages and its possible relationship sperm fertilizing ability. FF EVs were obtained by differential centrifugation. concentration size distribution analyzed nanoparticle tracking analysis. lipidome proteome liquid chromatography–mass spectrometry. isolated had a variety shapes sizes; their did not differ significantly between age groups. In younger than 35 years, vesicular progesterone 6.6 times higher older total levels main lipid classes increased women. A proteomic analysis revealed that only EV-specific proteins, but also proteins involved activation present. New data on EVs, confirming importance as indicators age-related changes female system. addition, these results shed light interaction groups male germ cells. Therefore, studying transcriptomic metabolomic profile may be crucial approach evaluate efficacy ART.
Язык: Английский
Процитировано
3