Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 746 - 746
Опубликована: Янв. 16, 2025
Atherosclerosis
is
accompanied
by
inflammation
that
underlies
cardiovascular
disease
(CVD)
and
its
vascular
manifestations,
including
acute
stroke,
myocardial
infarction,
peripheral
artery
disease,
the
leading
causes
of
morbidity/mortality
worldwide.
The
monolayer
endothelial
cells
formed
on
luminal
surface
arteries
veins
regulates
tone
permeability,
which
supports
homeostasis.
Endothelial
dysfunction,
first
step
in
development
atherosclerosis,
caused
mechanical
biochemical
factors
disrupt
homeostasis
induce
inflammation.
Together
with
increased
plasma
levels
low-density
lipoprotein
(LDL),
diabetes,
hypertension,
cigarette
smoking,
infectious
microorganisms,
genetic
factors,
epidemiological
studies
established
dysregulated
metabolism
homocysteine
(Hcy)
causing
hyperhomocysteinemia
(HHcy)
associated
CVD.
Patients
severe
HHcy
exhibit
CVD
die
prematurely
due
to
complications.
Biochemically,
characterized
elevated
Hcy
related
metabolites
such
as
Hcy-thiolactone
N-Hcy-protein,
seen
nutritional
deficiencies
humans
animals.
only
known
source
methionine
released
gut
from
dietary
protein.
generated
S-adenosylhomocysteine
(AdoHcy)
metabolized
cystathionine
β-synthase
(CBS)
methionyl-tRNA
synthetase.
Hcy-thiolactone,
a
chemically
reactive
thioester,
modifies
protein
lysine
residues,
generating
N-homocysteinylated
(N-Hcy)-protein.
N-Hcy-proteins
lose
their
normal
native
function
become
cytotoxic,
autoimmunogenic,
proinflammatory,
prothrombotic,
proatherogenic.
Accumulating
evidence,
discussed
this
review,
shows
these
can
promote
CVD,
stroke
inducing
pro-atherogenic
changes
gene
expression,
upregulating
mTOR
signaling,
inhibiting
autophagy
through
epigenetic
mechanisms
involving
specific
microRNAs,
histone
demethylase
PHF8,
methylated
H4K20me1.
Clinical
studies,
also
show
are
infarction
ischemic
influencing
blood
clotting.
These
findings
contribute
our
understanding
complex
underlying
identify
potential
targets
for
therapeutic
intervention.
Язык: Английский
GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 697 - 697
Опубликована: Июнь 6, 2024
Glutathione
(GSH),
a
prominent
antioxidant
in
organisms,
exhibits
diverse
biological
functions
and
is
crucial
safeguarding
cells
against
oxidative
harm
upholding
stable
redox
milieu.
The
metabolism
of
GSH
implicated
numerous
diseases,
particularly
the
progression
malignant
tumors.
Consequently,
therapeutic
strategies
targeting
regulation
synthesis
to
modulate
levels
represent
promising
avenue
for
future
research.
This
study
aimed
elucidate
intricate
relationship
between
ferroptosis,
highlighting
how
modulation
can
impact
cellular
susceptibility
ferroptosis
consequently
influence
development
tumors
other
diseases.
paper
provides
comprehensive
overview
physiological
GSH,
including
its
structural
characteristics,
physicochemical
properties,
sources,
metabolic
pathways,
as
well
investigate
molecular
mechanisms
underlying
potential
interventions.
Unraveling
role
holds
promise
individuals
afflicted
with
Язык: Английский
A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Neurodegenerative
diseases
represent
a
pressing
global
health
challenge,
and
the
identification
of
novel
mechanisms
underlying
their
pathogenesis
is
utmost
importance.
Ferroptosis,
non-apoptotic
form
regulated
cell
death
characterized
by
iron-dependent
lipid
peroxidation,
has
emerged
as
pivotal
player
in
neurodegenerative
diseases.
This
review
delves
into
discovery
ferroptosis,
critical
players
involved,
intricate
role
neurodegeneration,
with
an
emphasis
on
Alzheimer’s
Parkinson’s
We
critically
appraise
unsolved
mechanistic
links
involved
initiation
propagation
such
signaling
cascade
resulting
de-repression
lipoxygenase
translation
played
mitochondrial
voltage-dependent
anionic
channels
iron
homeostasis.
Particular
attention
given
to
dual
heme
oxygenase
which
may
be
linked
non-specific
activity
P450
reductase
endoplasmic
reticulum.
Despite
limited
knowledge
ferroptosis
progression
Nrf2/Bach1
target
genes
have
crucial
defenders
anti-ferroptotic
pathways.
The
activation
Nrf2
inhibition
Bach1
can
counteract
present
promising
avenue
for
future
therapeutic
interventions
targeting
Язык: Английский
Age-Dependent Changes in Taurine, Serine, and Methionine Release in the Frontal Cortex of Awake Freely-Moving Rats: A Microdialysis Study
Life,
Год журнала:
2025,
Номер
15(2), С. 295 - 295
Опубликована: Фев. 13, 2025
Brain
function
declines
because
of
aging
and
several
metabolites
change
their
concentration.
However,
this
decrease
may
be
a
consequence
or
driver
aging.
It
has
been
described
that
taurine
levels
with
age
supplementation
increases
health
span
in
mice
monkeys,
finding
as
The
frontal
cortex
is
one
the
most
key
areas
studied
to
know
normal
processes
cerebral
aging,
due
its
relevant
role
cognitive
processes,
emotion,
motivation.
In
present
work,
we
analyzed
by
intracerebral
microdialysis
vivo
prefrontal
young
(3
months)
old
(24
awake
rats,
basal-
K+-evoked
release
taurine,
precursors
methionine
serine.
taurine/serine/methionine
(TSM)
ratio
was
also
calculated
an
index
transmethylation
reactions.
No
changes
were
found
basal
serine,
between
aged
animals.
On
contrary,
significant
serine
appeared
rats
when
compared
seen
methionine.
TSM
decreased
both
K+-stimulated
conditions.
Therefore,
related
precursor
animals
under
but
not
conditions,
which
supports
importance
decline
evoked
functions
at
brain
level,
supporting
idea
proposed
other
authors
pharmacological
and/or
nutritional
intervention
restoration.
A
deficit
for
reactions
considered.
Язык: Английский
Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation
Wiley Interdisciplinary Reviews - RNA,
Год журнала:
2025,
Номер
16(2)
Опубликована: Март 1, 2025
ABSTRACT
Transfer
RNA
(tRNA)
is
not
merely
a
passive
carrier
of
amino
acids,
but
an
active
regulator
mRNA
translation
controlling
codon
bias
and
optimality.
The
synthesis
various
tRNA
modifications
regulated
by
many
“writer”
enzymes,
which
utilize
substrates
from
metabolic
pathways
or
dietary
sources.
Metabolic
bioenergetic
pathways,
such
as
one‐carbon
(1C)
metabolism
the
tricarboxylic
acid
(TCA)
cycle
produce
essential
for
synthesis,
S‐Adenosyl
methionine
(SAM),
sulfur
species,
α‐ketoglutarate
(α‐KG).
activity
these
can
directly
impact
decoding
via
regulating
levels.
In
this
review,
we
discuss
complex
interactions
between
diet,
metabolism,
modifications,
translation.
We
how
nutrient
availability,
bioenergetics,
intermediates
modulate
modification
landscape
to
fine‐tune
protein
synthesis.
Moreover,
highlight
dysregulation
metabolic‐tRNA
contributes
disease
pathogenesis,
including
cancer,
disorders,
neurodegenerative
diseases.
also
new
emerging
field
GlycoRNA
biology
drawing
parallels
glycobiology
diseases
guide
future
directions
in
area.
Throughout
our
discussion,
links
specific
their
metabolic/dietary
precursors,
diseases,
emphasizing
importance
metabolism‐centric
view
understanding
pathologies.
Future
research
should
focus
on
uncovering
interplay
cellular
contexts.
Addressing
gaps
will
into
novel
interventions.
Язык: Английский
The role of the gut microbiome in Parkinson’s disease
Future Neurology,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 29, 2025
Язык: Английский
The methionine cycle and its cancer implications
Oncogene,
Год журнала:
2024,
Номер
43(48), С. 3483 - 3488
Опубликована: Окт. 11, 2024
Язык: Английский
Metabolomic changes in children with autism
World Journal of Clinical Pediatrics,
Год журнала:
2024,
Номер
13(2)
Опубликована: Июнь 7, 2024
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
condition
characterized
by
deficits
in
social
communication
and
repetitive
behaviors.
Metabolomic
profiling
has
emerged
as
valuable
tool
for
understanding
the
underlying
metabolic
dysregulations
associated
with
ASD.
Язык: Английский
Ferroptosis: a potential target for acute lung injury
Inflammation Research,
Год журнала:
2024,
Номер
73(10), С. 1615 - 1629
Опубликована: Авг. 17, 2024
Язык: Английский
Formation of CSE-YAP complex drives FOXD3-mediated transition of neurotoxic astrocytes in Parkinson’s disease
Pharmacological Research,
Год журнала:
2024,
Номер
210, С. 107507 - 107507
Опубликована: Ноя. 14, 2024
Astrocytes,
constituting
the
predominant
glial
cells
in
brain,
undergo
significant
morphological
and
functional
transformations
amidst
progression
of
Parkinson's
disease
(PD).
A
majority
these
reactive
astrocytes
display
a
neurotoxic
phenotype,
intensifying
inflammatory
responses.
Nonetheless,
molecular
underpinnings
steering
astrocyte
reactivity
during
PD
remain
mostly
uncharted.
Here,
we
uncover
unique
role
cystathionine
γ-lyase
(CSE)
shaping
reactivity,
primarily
channeling
towards
thereby
escalating
neuroinflammation
PD.
Single-cell
sequencing
data
drawn
from
patients
coupled
with
RNA
MPP
Язык: Английский