Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 25, 2024

Abstract Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices transmodal association cortices. Here, we investigate hypothesis development functional connectivity during childhood through adolescence conforms hierarchy defined by axis. We tested this pre-registered in four large-scale, independent datasets (total n = 3355; ages 5–23 years): Philadelphia Neurodevelopmental Cohort ( 1207), Nathan Kline Institute-Rockland Sample 397), Connectome Project: Development 625), and Healthy Brain Network 1126). Across datasets, systematically varied Connectivity regions increased, whereas declined, refining reinforcing hierarchy. These consistent generalizable results establish encodes dominant pattern development.

Язык: Английский

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Hierarchical functional system development supports executive function

Trends in Cognitive Sciences, Год журнала: 2022, Номер 27(2), С. 160 - 174

Опубликована: Ноя. 24, 2022

Язык: Английский

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Neighborhood poverty during childhood prospectively predicts adolescent functional brain network architecture

Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 64, С. 101316 - 101316

Опубликована: Окт. 14, 2023

Family poverty has been associated with altered brain structure, function, and connectivity in youth. However, few studies have examined how disadvantage within the broader neighborhood may influence functional network organization. The present study leveraged a longitudinal community sample of 538 twins living low-income neighborhoods to evaluate prospective association between exposure during childhood (6-10 y) architecture adolescence (8-19 y). Using resting-state task-based fMRI, we generated two latent measures that captured intrinsic organization across whole-brain levels - segregation segregation-integration balance. While age was positively balance overall sample, these associations were moderated by poverty. Specifically, positive observed only youth from more, but not less, disadvantaged neighborhoods. Moreover, greater predicted reduced early, middle or late, adolescence. These effects detected both system as well specific networks, including fronto-parietal, default mode, salience, subcortical systems. findings indicate where children live exert long-reaching on development adolescent brain.

Язык: Английский

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Visual word processing engages a hierarchical, distributed, and bilateral cortical network

iScience, Год журнала: 2024, Номер 27(2), С. 108809 - 108809

Опубликована: Янв. 6, 2024

Highlights•The visual word processing network is modulated bilaterally by textual stimulus type•The composed of three clusters arrayed on the posterior-anterior brain axis•VWFA emerges as a mediator between early vision and language clusters•Region-level stimulus-mediated modulation, but network-level stability, observedSummaryAlthough Visual Word Form Area (VWFA) in left temporal cortex considered pre-eminent region processing, other regions are also implicated. We examined entire text-selective circuit, using functional MRI. Ten interest (ROIs) per hemisphere were defined, which, based clustering, grouped into vision, high-level clusters. analyzed responses ROIs to words, inverted consonant strings univariate, multivariate, connectivity measures. Bilateral modulation condition was evident, with stronger effect regions. Last, graph theory, we observed that VWFA equivalently connected both hemispheres, reflecting its role circuit. Although individual flexibly altered nature input, stability held at level global circuit connectivity, complex hierarchical distributed system serving text perception.Graphical abstract

Язык: Английский

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The Development of Executive Function: Mechanisms of Change and Functional Pressures

Journal of Cognition and Development, Год журнала: 2023, Номер 24(2), С. 172 - 190

Опубликована: Янв. 5, 2023

This developmental account of executive function (EF) argues that domain-general analogical processes build a functional hierarchy skills, which vary on continuum abstraction, and become increasingly differentiated over time. The paper begins by showing how can capture important aspects EF development, including incrementalism, partial differentiation, shift from reactive to proactive control. It then details children construct this in they make analogies between similar problems, bottom-up incremental fashion. results structure becomes into components are more suited solving some goal-directed problems than others. implications eventually acquire task-general EFs while also retaining goal-specific skills sensitive wider beliefs, values, norms, preferences, relevant motor, procedural, embodied knowledge. There is discussion approach different existing accounts, it relates broader issues training transfer, group individual differences, overlapping functions learning. mechanisms advocated under intentionally draw neuropsychological, learning cognitive have been demonstrated other domains, so theory benefit the lessons learned elsewhere integrated with areas cognition.

Язык: Английский

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Prenatal environment is associated with the pace of cortical network development over the first three years of life

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 11, 2024

Язык: Английский

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Canonical neurodevelopmental trajectories of structural and functional manifolds

Опубликована: Янв. 13, 2025

Organisational gradients refer to a continuous low-dimensional embedding of brain regions and can quantify core organisational principles complex systems like the human brain. Mapping how these are altered or refined across development phenotypes is essential understanding relationship between behaviour. Taking developmental approach leveraging longitudinal cross-sectional data from two multi-modal neuroimaging datasets, spanning full neurotypical-neurodivergent continuum, we charted variability structural (N = 887) functional 728) gradients, childhood adolescence (6-19 years old). Across despite differing phenotypes, observe highly similar gradients. These principles, stable development, with exact same ordering early into mid-adolescence. However, there substantial change in strength within those gradients: by modelling trajectories as non-linear splines, show that exhibit sensitive periods development. Specifically, gradually contract space networks become more integrated, whilst manifold expands, indexing specialisation. The coupling follows unimodal-association axis varies individuals, effects concentrated plastic higher-order networks. Importantly, on coupling, networks, attenuated neurodivergent sample. Finally, mapped structure-function onto dimensions psychopathology cognition demonstrate robust predictor cognition, such working memory, but not psychopathology. In summary, clinical community samples, consistent organisation, progressive integration segregation. established life, through their memory.

Язык: Английский

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Canonical neurodevelopmental trajectories of structural and functional manifolds

Опубликована: Янв. 13, 2025

Organisational gradients refer to a continuous low-dimensional embedding of brain regions and can quantify core organisational principles complex systems like the human brain. Mapping how these are altered or refined across development phenotypes is essential understanding relationship between behaviour. Taking developmental approach leveraging longitudinal cross-sectional data from two multi-modal neuroimaging datasets, spanning full neurotypical-neurodivergent continuum, we charted variability structural (N = 887) functional 728) gradients, childhood adolescence (6-19 years old). Across despite differing phenotypes, observe highly similar gradients. These principles, stable development, with exact same ordering early into mid-adolescence. However, there substantial change in strength within those gradients: by modelling trajectories as non-linear splines, show that exhibit sensitive periods development. Specifically, gradually contract space networks become more integrated, whilst manifold expands, indexing specialisation. The coupling follows unimodal-association axis varies individuals, effects concentrated plastic higher-order networks. Importantly, on coupling, networks, attenuated neurodivergent sample. Finally, mapped structure-function onto dimensions psychopathology cognition demonstrate robust predictor cognition, such working memory, but not psychopathology. In summary, clinical community samples, consistent organisation, progressive integration segregation. established life, through their memory.

Язык: Английский

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Fiber Length Distribution Characterizes the Brain Network Maturation during Early School-age

NeuroImage, Год журнала: 2025, Номер unknown, С. 121066 - 121066

Опубликована: Янв. 1, 2025

Environmental and social changes during early school age have a profound impact on brain development. However, it remains unclear how the brains of typically-developing children adjust white matter to optimize network topology this period. This study aims propose fiber length distribution as novel nodal metric capture continuous maturation network. We scanned dMRI among N=30 in their first year primary one-year follow up. assessed longitudinal distribution, characterized by median connected fibers for each region. The was positively correlated with degree betweenness centrality, while negatively clustering coefficient local efficiency. From ages 7 8, we observed significant decreases temporal, superior parietal, anterior cingulate, medial prefrontal cortex, accompanied reduction long-range connections an increase short-range connections. Meta-analytic decoding revealed that widespread decrease occurred regions responsible sensory processing, whereas more localized involved memory cognitive control. Finally, simulations test healthy adults further support connection contributed increased segregation integration, respectively. Our results suggest dual process short- reflects cost-efficient strategy optimizing organization critical developmental stage.

Язык: Английский

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An uniformity index for random geometric graphs

Statistics, Год журнала: 2025, Номер unknown, С. 1 - 21

Опубликована: Март 24, 2025

Язык: Английский

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