Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Авг. 30, 2023
The
bed
nucleus
of
the
stria
terminalis
(BNST),
as
part
extended
amygdala,
has
become
a
region
increasing
interest
regarding
its
role
in
numerous
human
stress-related
psychiatric
diseases,
including
post-traumatic
stress
disorder
and
generalized
anxiety
amongst
others.
BNST
is
sexually
dimorphic
highly
complex
structure
already
evident
by
anatomy
consisting
11
to
18
distinct
sub-nuclei
rodents.
Located
ventral
forebrain,
anatomically
functionally
connected
many
other
limbic
structures,
hypothalamic
nuclei,
basal
ganglia,
hippocampus.
Given
this
extensive
connectivity,
thought
play
central
critical
integration
information
on
hedonic-valence,
mood,
arousal
states,
processing
emotional
information,
general
shape
motivated
stress/anxiety-related
behavior.
Regarding
regulating
behavior
anterolateral
group
(BNSTALG)
been
extensively
studied
contains
wide
variety
neurons
that
differ
their
electrophysiological
properties,
morphology,
spatial
organization,
neuropeptidergic
content
input
output
synaptic
organization
which
activity
function.
In
addition
great
diversity,
further
species-specific
differences
are
multiple
levels.
For
example,
classic
studies
performed
adult
rat
brain
identified
three
neuron
types
(Type
I-III)
based
properties
ion
channel
expression.
Whilst
similar
have
animal
species,
such
mice
non-human
primates
macaques,
cross-species
comparisons
revealed
intriguing
comparative
prevalence
BNSTALG
well
morphological
differences.
tremendous
complexity
levels,
comprehensive
elucidation
circuitry
major
challenge.
present
Review
we
bring
together
highlight
key
structure,
functional
profiles
between
species
with
aim
facilitate
future
important
relation
disease.
Nature,
Год журнала:
2022,
Номер
606(7912), С. 153 - 159
Опубликована: Май 4, 2022
Abstract
Oestradiol
establishes
neural
sex
differences
in
many
vertebrates
1–3
and
modulates
mood,
behaviour
energy
balance
adulthood
4–8
.
In
the
canonical
pathway,
oestradiol
exerts
its
effects
through
transcription
factor
oestrogen
receptor-α
(ERα)
9
Although
ERα
has
been
extensively
characterized
breast
cancer,
neuronal
targets
of
ERα,
their
involvement
brain
differences,
remain
largely
unknown.
Here
we
generate
a
comprehensive
map
genomic
ERα-binding
sites
sexually
dimorphic
circuit
that
mediates
social
behaviours.
We
conclude
orchestrates
sexual
differentiation
mouse
two
mechanisms:
establishing
male-biased
neuron
types
activating
sustained
gene
expression
program.
Collectively,
our
findings
reveal
are
defined
by
hormonal
activation
steroid
receptors.
The
molecular
identify
may
underlie
on
development,
disease.
Biological Psychiatry,
Год журнала:
2021,
Номер
89(9), С. 847 - 856
Опубликована: Янв. 8, 2021
Brain
systems
that
promote
maintenance
of
homeostasis
in
the
face
stress
have
significant
adaptive
value.
A
growing
body
work
across
species
demonstrates
a
critical
role
for
amygdala
promoting
by
regulating
physiological
and
behavioral
responses
to
stress.
This
review
focuses
on
an
emerging
evidence
has
begun
delineate
contribution
specific
long-range
circuits
mediating
effects
After
summarizing
major
anatomical
features
its
connectivity
other
limbic
structures,
we
discuss
recent
findings
from
rodents
showing
how
causes
structural
functional
remodeling
neuronal
outputs
defined
cortical
subcortical
target
regions.
We
also
consider
some
environmental
genetic
factors
been
found
moderate
responds
relate
preclinical
literature
current
understanding
pathophysiology
treatment
stress-related
neuropsychiatric
disorders.
Future
effort
translate
these
clinics
may
help
develop
valuable
tools
prevention,
diagnosis,
diseases.
Frontiers in Behavioral Neuroscience,
Год журнала:
2021,
Номер
15
Опубликована: Фев. 24, 2021
The
brain
anxiety
network
is
composed
of
a
number
interconnected
cortical
regions
that
detect
threats
and
execute
appropriate
defensive
responses
via
projections
to
the
shell
nucleus
accumbens
(NAcSh),
dorsolateral
region
bed
stria
terminalis
(BSTDL)
lateral
central
amygdala
(CeL).
paraventricular
thalamus
(PVT)
anatomically
positioned
integrate
threat-
arousal-related
signals
from
cortex
hypothalamus
then
relay
these
neural
circuits
in
NAcSh,
BSTDL,
CeL
mediate
responses.
This
review
describes
anatomical
connections
PVT
support
view
may
be
critical
node
network.
Experimental
findings
are
reviewed
showing
arousal
peptides
orexins
(hypocretins)
act
at
promote
avoidance
potential
especially
following
exposure
rats
single
episode
footshocks.
Recent
experimental
discussed
which
show
neurons
provide
divergent
subcortical
behaviors
projection
NAcSh
for
enhanced
social
displayed
exposed
A
theoretical
model
proposed
how
integrates
hypothalamic
modulate
behavioral
associated
with
other
challenging
situations.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 10, 2024
Abstract
Anxiety-associated
symptoms
following
acute
stress
usually
become
extinct
gradually
within
a
period
of
time.
However,
the
mechanisms
underlying
how
individuals
cope
with
to
achieve
extinction
anxiety
are
not
clear.
Here
we
show
that
restraint
causes
an
increase
in
activity
GABAergic
neurons
CeA
(GABA
)
male
mice,
resulting
anxiety-like
behaviors
12
hours;
meanwhile,
elevated
GABA
neuronal
CX3CL1
secretion
via
MST4
(mammalian
sterile-20-like
kinase
4)-NF-κB-CX3CL1
signaling
consequently
activates
microglia
CeA.
Activated
turn
inhibit
engulfment
their
dendritic
spines,
ultimately
leading
induced
by
stress.
These
findings
reveal
dynamic
molecular
and
cellular
mechanism
which
drive
negative
feedback
activity,
thus
facilitating
maintenance
brain
homeostasis
response
Journal of Neuroscience,
Год журнала:
2018,
Номер
39(6), С. 1030 - 1043
Опубликована: Дек. 10, 2018
The
central
amygdala
(CeA)
is
important
for
fear
responses
to
discrete
cues.
Recent
findings
indicate
that
the
CeA
also
contributes
states
of
sustained
apprehension
characterize
anxiety,
although
little
known
about
neural
circuitry
involved.
stress
neuropeptide
corticotropin
releasing
factor
(CRF)
anxiogenic
and
produced
by
subpopulations
neurons
in
lateral
dorsolateral
bed
nucleus
stria
terminalis
(dlBST).
Here
we
investigated
function
these
CRF
stress-induced
anxiety
using
chemogenetics
male
rats
express
Cre
recombinase
from
a
Crh
promoter.
Anxiety-like
behavior
was
mediated
projections
dlBST
depended
on
activation
CRF1
receptors
within
dlBST.
Our
identify
→CRF
circuit
generating
anxiety-like
provide
mechanistic
support
recent
human
primate
data
suggesting
BST
act
together
generate
anxiety.
SIGNIFICANCE
STATEMENT
Anxiety
negative
emotional
state
critical
survival,
but
persistent,
exaggerated
causes
substantial
morbidity.
Identifying
brain
regions
neurotransmitter
systems
drive
can
help
developing
effective
treatment.
Much
evidence
rodents
indicates
(BST)
behaviors,
more
implicate
CeA.
neuronal
are
currently
subjects
intense
investigation.
show
release
corticotropin-releasing
behaviors
via
pathway
dorsal
activates
local
neurons.
Thus,
our
CeA→BST
generates
behavior.
Journal of Neuroscience,
Год журнала:
2020,
Номер
40(41), С. 7949 - 7964
Опубликована: Сен. 21, 2020
When
extreme,
anxiety—a
state
of
distress
and
arousal
prototypically
evoked
by
uncertain
danger—can
be
debilitating.
Uncertain
anticipation
is
a
shared
feature
situations
that
elicit
signs
symptoms
anxiety
across
psychiatric
disorders,
species,
assays.
Despite
the
profound
significance
for
human
health
wellbeing,
neurobiology
uncertain-threat
remains
unsettled.
Leveraging
paradigm
adapted
from
animal
research
optimized
fMRI
signal
decomposition,
we
examined
neural
circuits
engaged
during
temporally
certain
threat
in
99
men
women.
Results
revealed
systems
recruited
are
anatomically
colocalized
frontocortical
regions,
extended
amygdala,
periaqueductal
gray.
Comparison
conditions
demonstrated
this
circuitry
can
fractionated,
with
regions
showing
relatively
stronger
engagement
threat,
amygdala
reverse
pattern.
Although
there
widespread
agreement
bed
nucleus
stria
terminalis
dorsal
amygdala—the
two
major
subdivisions
amygdala—play
critical
role
orchestrating
adaptive
responses
to
potential
danger,
their
precise
contributions
have
remained
contentious.
Follow-up
analyses
these
show
statistically
indistinguishable
anticipation.
These
observations
provide
framework
conceptualizing
fear,
understanding
functional
neuroanatomy
humans,
accelerating
development
more
effective
intervention
strategies
pathological
anxiety.
SIGNIFICANCE
STATEMENT
Anxiety—an
emotion
associated
harm—has
public
health,
yet
underlying
unclear.
novel
neuroimaging
large
sample,
identify
core
circuit
responsive
both
anticipation,
fractionated
into
bias
one
kind
or
other.
The
occupies
center
stage
neuropsychiatric
models
anxiety,
but
its
architecture
has
Here
demonstrate
threat.
Collectively,
indicate
need
revise
how
think
about
fear.