The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species DOI Creative Commons

Yana van de Poll,

Yasmin Cras,

Tommas J. Ellender

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Авг. 30, 2023

The bed nucleus of the stria terminalis (BNST), as part extended amygdala, has become a region increasing interest regarding its role in numerous human stress-related psychiatric diseases, including post-traumatic stress disorder and generalized anxiety amongst others. BNST is sexually dimorphic highly complex structure already evident by anatomy consisting 11 to 18 distinct sub-nuclei rodents. Located ventral forebrain, anatomically functionally connected many other limbic structures, hypothalamic nuclei, basal ganglia, hippocampus. Given this extensive connectivity, thought play central critical integration information on hedonic-valence, mood, arousal states, processing emotional information, general shape motivated stress/anxiety-related behavior. Regarding regulating behavior anterolateral group (BNSTALG) been extensively studied contains wide variety neurons that differ their electrophysiological properties, morphology, spatial organization, neuropeptidergic content input output synaptic organization which activity function. In addition great diversity, further species-specific differences are multiple levels. For example, classic studies performed adult rat brain identified three neuron types (Type I-III) based properties ion channel expression. Whilst similar have animal species, such mice non-human primates macaques, cross-species comparisons revealed intriguing comparative prevalence BNSTALG well morphological differences. tremendous complexity levels, comprehensive elucidation circuitry major challenge. present Review we bring together highlight key structure, functional profiles between species with aim facilitate future important relation disease.

Язык: Английский

A gut-derived metabolite alters brain activity and anxiety behaviour in mice DOI
Brittany D. Needham,

Masanori Funabashi,

Mark D. Adame

и другие.

Nature, Год журнала: 2022, Номер 602(7898), С. 647 - 653

Опубликована: Фев. 14, 2022

Язык: Английский

Процитировано

316
Gene regulation by gonadal hormone receptors underlies brain sex differences DOI Creative Commons
Bruno Gegenhuber, Melody V. Wu, Robert Bronstein

и другие.

Nature, Год журнала: 2022, Номер 606(7912), С. 153 - 159

Опубликована: Май 4, 2022

Abstract Oestradiol establishes neural sex differences in many vertebrates 1–3 and modulates mood, behaviour energy balance adulthood 4–8 . In the canonical pathway, oestradiol exerts its effects through transcription factor oestrogen receptor-α (ERα) 9 Although ERα has been extensively characterized breast cancer, neuronal targets of ERα, their involvement brain differences, remain largely unknown. Here we generate a comprehensive map genomic ERα-binding sites sexually dimorphic circuit that mediates social behaviours. We conclude orchestrates sexual differentiation mouse two mechanisms: establishing male-biased neuron types activating sustained gene expression program. Collectively, our findings reveal are defined by hormonal activation steroid receptors. The molecular identify may underlie on development, disease.

Язык: Английский

Процитировано

146
Amygdala Circuit Substrates for Stress Adaptation and Adversity DOI Creative Commons
Wen-Hua Zhang, Junyu Zhang, Andrew Holmes

и другие.

Biological Psychiatry, Год журнала: 2021, Номер 89(9), С. 847 - 856

Опубликована: Янв. 8, 2021

Brain systems that promote maintenance of homeostasis in the face stress have significant adaptive value. A growing body work across species demonstrates a critical role for amygdala promoting by regulating physiological and behavioral responses to stress. This review focuses on an emerging evidence has begun delineate contribution specific long-range circuits mediating effects After summarizing major anatomical features its connectivity other limbic structures, we discuss recent findings from rodents showing how causes structural functional remodeling neuronal outputs defined cortical subcortical target regions. We also consider some environmental genetic factors been found moderate responds relate preclinical literature current understanding pathophysiology treatment stress-related neuropsychiatric disorders. Future effort translate these clinics may help develop valuable tools prevention, diagnosis, diseases.

Язык: Английский

Процитировано

142
Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior DOI
Guangwei Zhang, Li Shen, Can Tao

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(4), С. 516 - 528

Опубликована: Фев. 1, 2021

Язык: Английский

Процитировано

121
The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network DOI Creative Commons
Gilbert J. Kirouac

Frontiers in Behavioral Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Фев. 24, 2021

The brain anxiety network is composed of a number interconnected cortical regions that detect threats and execute appropriate defensive responses via projections to the shell nucleus accumbens (NAcSh), dorsolateral region bed stria terminalis (BSTDL) lateral central amygdala (CeL). paraventricular thalamus (PVT) anatomically positioned integrate threat- arousal-related signals from cortex hypothalamus then relay these neural circuits in NAcSh, BSTDL, CeL mediate responses. This review describes anatomical connections PVT support view may be critical node network. Experimental findings are reviewed showing arousal peptides orexins (hypocretins) act at promote avoidance potential especially following exposure rats single episode footshocks. Recent experimental discussed which show neurons provide divergent subcortical behaviors projection NAcSh for enhanced social displayed exposed A theoretical model proposed how integrates hypothalamic modulate behavioral associated with other challenging situations.

Язык: Английский

Процитировано

115
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states DOI
Xia Zhu,

Hao-Di Tang,

Wanying Dong

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(4), С. 542 - 553

Опубликована: Март 8, 2021

Язык: Английский

Процитировано

108
The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum DOI
Justin M. Moscarello, Mario A. Penzo

Nature Neuroscience, Год журнала: 2022, Номер 25(8), С. 999 - 1008

Опубликована: Авг. 1, 2022

Язык: Английский

Процитировано

75
Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice DOI Creative Commons
Danyang Chen,

Qian-Qian Lou,

Xiang-Jie Song

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 10, 2024

Abstract Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with to achieve extinction anxiety are not clear. Here we show that restraint causes an increase in activity GABAergic neurons CeA (GABA ) male mice, resulting anxiety-like behaviors 12 hours; meanwhile, elevated GABA neuronal CX3CL1 secretion via MST4 (mammalian sterile-20-like kinase 4)-NF-κB-CX3CL1 signaling consequently activates microglia CeA. Activated turn inhibit engulfment their dendritic spines, ultimately leading induced by stress. These findings reveal dynamic molecular and cellular mechanism which drive negative feedback activity, thus facilitating maintenance brain homeostasis response

Язык: Английский

Процитировано

46
A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety DOI Creative Commons
Matthew B. Pomrenze, Jorge Tovar-Díaz,

Angelo Blasio

и другие.

Journal of Neuroscience, Год журнала: 2018, Номер 39(6), С. 1030 - 1043

Опубликована: Дек. 10, 2018

The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes states of sustained apprehension characterize anxiety, although little known about neural circuitry involved. stress neuropeptide corticotropin releasing factor (CRF) anxiogenic and produced by subpopulations neurons in lateral dorsolateral bed nucleus stria terminalis (dlBST). Here we investigated function these CRF stress-induced anxiety using chemogenetics male rats express Cre recombinase from a Crh promoter. Anxiety-like behavior was mediated projections dlBST depended on activation CRF1 receptors within dlBST. Our identify →CRF circuit generating anxiety-like provide mechanistic support recent human primate data suggesting BST act together generate anxiety. SIGNIFICANCE STATEMENT Anxiety negative emotional state critical survival, but persistent, exaggerated causes substantial morbidity. Identifying brain regions neurotransmitter systems drive can help developing effective treatment. Much evidence rodents indicates (BST) behaviors, more implicate CeA. neuronal are currently subjects intense investigation. show release corticotropin-releasing behaviors via pathway dorsal activates local neurons. Thus, our CeA→BST generates behavior.

Язык: Английский

Процитировано

130
Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation DOI Creative Commons
Juyoen Hur,

Jason F. Smith,

Kathryn A. DeYoung

и другие.

Journal of Neuroscience, Год журнала: 2020, Номер 40(41), С. 7949 - 7964

Опубликована: Сен. 21, 2020

When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain danger—can be debilitating. Uncertain anticipation is a shared feature situations that elicit signs symptoms anxiety across psychiatric disorders, species, assays. Despite the profound significance for human health wellbeing, neurobiology uncertain-threat remains unsettled. Leveraging paradigm adapted from animal research optimized fMRI signal decomposition, we examined neural circuits engaged during temporally certain threat in 99 men women. Results revealed systems recruited are anatomically colocalized frontocortical regions, extended amygdala, periaqueductal gray. Comparison conditions demonstrated this circuitry can fractionated, with regions showing relatively stronger engagement threat, amygdala reverse pattern. Although there widespread agreement bed nucleus stria terminalis dorsal amygdala—the two major subdivisions amygdala—play critical role orchestrating adaptive responses to potential danger, their precise contributions have remained contentious. Follow-up analyses these show statistically indistinguishable anticipation. These observations provide framework conceptualizing fear, understanding functional neuroanatomy humans, accelerating development more effective intervention strategies pathological anxiety. SIGNIFICANCE STATEMENT Anxiety—an emotion associated harm—has public health, yet underlying unclear. novel neuroimaging large sample, identify core circuit responsive both anticipation, fractionated into bias one kind or other. The occupies center stage neuropsychiatric models anxiety, but its architecture has Here demonstrate threat. Collectively, indicate need revise how think about fear.

Язык: Английский

Процитировано

99