Co-occurrence of Hyperacusis Accelerates With Tinnitus Burden Over Time and Requires Medical Care DOI Creative Commons
Fatma Refat,

Jakob Wertz,

Pauline Hinrichs

и другие.

Frontiers in Neurology, Год журнала: 2021, Номер 12

Опубликована: Март 18, 2021

Although tinnitus represents a major global burden, no causal therapy has yet been established. Ongoing controversies about the neuronal pathophysiology of hamper efforts in developing advanced therapies. Hypothesizing that unnoticed co-occurrence hyperacusis and differences duration may possibly differentially influence neural correlate tinnitus, we analyzed 33 patients without (T-group) 20 with (TH-group). We found crucial between T-group TH-group increase annoyance, complaints, loudness, central gain as function duration. Hearing thresholds did not differ TH-group. In TH-group, complaints (total score) were significantly greater from early on intensity distinctly increased over time ca. 12 to 17 dB when persisted more than 5 years, while annoyance responses normal sound remained nearly constant. contrast, constant, although declined 27 down 15 beyond years persistence. This was explained through gradually time, shown by questionnaire. Parallel shift mainly unilateral (only 17% bilateral) completely bilateral (100%) percept occurred T-group, dominated start (75%). Over ABR wave V amplitudes (and V/I ratios) reduced delayed. By especially III III/I ratio) continued be enhanced shortened response high-level stimuli. Interestingly, line signs an also slightly T-group. The findings disclose undiagnosed main cause distress time. To achieve urgently needed personalized therapies, using objective tools offered here, systematic sub-classification is recommended.

Язык: Английский

Hyperacusis and Tinnitus DOI
Martin Schecklmann, Laure Jacquemin, David Baguley

и другие.

Springer eBooks, Год журнала: 2024, Номер unknown, С. 501 - 513

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

6
Neuroanatomical alterations in middle frontal gyrus and the precuneus related to tinnitus and tinnitus distress DOI Creative Commons
Stephanie Rosemann, Josef P. Rauschecker

Hearing Research, Год журнала: 2022, Номер 424, С. 108595 - 108595

Опубликована: Авг. 1, 2022

Tinnitus is the phantom perception of sound when there no external auditory input. This mostly perceived as a ringing, whistling or buzzing in ear. There evidence neural changes both central regions well other brain areas like prefrontal cortex and limbic system. However, morphological studies assessing gray matter volume cortical thickness have shown inconsistent results. We here investigated neuroanatomical alterations tinnitus related to along with distress cognitive abilities. Twenty patients 20 control participants matched age, sex hearing loss participated study. They underwent magnetic resonance imaging audiometric assessments. Our results demonstrate increased middle frontal gyrus pole compared participants. Moreover, we found precuneus associated an interaction between group assessment scores gyrus, indicating higher better controls lower patients. These findings indicate that awareness annoyance reflected structural precuneus, may also implications on general

Язык: Английский

Процитировано

19
Neuron Compatibility and Antioxidant Activity of Barium Titanate and Lithium Niobate Nanoparticles DOI Open Access
Mariarita Candito, Edi Simoni, Erica Gentilin

и другие.

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1761 - 1761

Опубликована: Фев. 3, 2022

The biocompatibility and the antioxidant activity of barium titanate (BaTiO3) lithium niobate (LiNbO3) were investigated on a neuronal cell line, PC12, to explore possibility using piezoelectric nanoparticles in treatment inner ear diseases, avoiding damage neurons, most delicate sensitive human cells. cytocompatibility compounds was verified by analysing viability, morphology, apoptotic markers, oxidative stress neurite outgrowth. results showed that BaTiO3 LiNbO3 do not affect morphological features, cytochrome c distribution production reactive oxygen species (ROS) PC12 cells, stimulate branching. These data suggest nanoparticles, they could be suitable candidates improve efficiency new implantable hearing devices without damaging

Язык: Английский

Процитировано

18
Current and Emerging Therapies for Chronic Subjective Tinnitus DOI Open Access
Ki Wan Park, Peter Kullar, Charvi Malhotra

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(20), С. 6555 - 6555

Опубликована: Окт. 16, 2023

Importance: Chronic subjective tinnitus, the perception of sound without an external source for longer than six months, may be a greatly debilitating condition some people, and is associated with psychiatric comorbidities high healthcare costs. Current treatments are not beneficial all patients there large need new therapies tinnitus. Observations: Unlike rarer cases objective chronic tinnitus often has no obvious etiology diverse pathophysiology. In absence testing, diagnosis heavily based on clinical assessment. Management strategies include hearing aids, masking, retraining therapy, cognitive behavioral emerging including transcranial magnetic stimulation electrical stimulation. Conclusions relevance: Although current limited, diagnostics provide promising avenues management symptoms.

Язык: Английский

Процитировано

10
Distinct profiles of tinnitus and hyperacusis in intensity deviant responses and auditory evoked potentials DOI Creative Commons
Ekaterina A Yukhnovich, Kai Alter, William Sedley

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 3, 2024

Abstract ERPs in response to intensity deviant stimuli are assessed four age and hearing matched groups of various combinations tinnitus hyperacusis (both conditions, one the neither condition). Distinct profiles for shown, as well additional more nuanced interactions. This not only moves our understanding each condition, but also speaks directly possible mechanistic subtypes (and hyperacusis) which might be disentangled through cheap available technique that is single-channel EEG. The current findings may explain some discrepant past literature.

Язык: Английский

Процитировано

4
Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis DOI Creative Commons
Feifan Chen, Fei Zhao, Nadeem Mahafza

и другие.

Frontiers in Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Дек. 20, 2021

Noise-induced cochlear synaptopathy (CS) is defined as a permanent loss of synapses in the auditory nerve pathway following noise exposure. Several studies using brainstem response (ABR) have indicated presence CS and increased central gain tinnitus patients with normal hearing thresholds (TNHT), but results were inconsistent. This meta-analysis aimed to review evidence its pathological changes system TNHT. Published ABR study TNHT reviewed. PubMed, EMBASE, Scopus databases selected search for relevant literature. Studies (489) retrieved, 11 included meta-analysis. The supported significantly reduced wave I amplitude TNHT, whereas alternations V inconsistent among studies. Consistently V/I ratio noise-induced enhancement. hearing. However, may be explained by that failure triggers neural and/or necessary generate not maintain tinnitus.

Язык: Английский

Процитировано

21
Tinnitus reduction in patients with single-sided deafness: the effect of cochlear implantation, bone conduction devices, and contralateral routing of sound hearing aids investigated in a randomized controlled trial DOI Creative Commons
Anne W. Wendrich, Kelly K. S. Assouly, Jan A. A. van Heteren

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Июль 23, 2024

Objectives Single-sided deafness (SSD) is often accompanied by tinnitus, resulting in a decreased quality of life. Currently, there lack high level evidence studies comparing different treatment options for SSD regarding tinnitus reduction. This randomized controlled trial (RCT) evaluated the effect cochlear implant (CI), bone conduction device (BCD), contralateral routing sound (CROS), and no on outcomes patients, with follow-up extending to 24 months. Methods A total 120 adult patients were three groups: CI, period first BCD headband, then CROS, or vice versa. After periods, opted BCD, treatment. At start follow-up, 28 implanted 25 34 had 26 chose The Tinnitus Handicap Inventory (THI), Questionnaire (TQ), Visual Analog Scale (VAS), Hospital Anxiety Depression (HADS) completed at baseline 3, 6, 12, months follow-up. Results CI groups showed significantly impact scores. group largest decrease, which was already observed 3 Compared baseline, median THI score 23 points, TQ 17 VAS 60 points In group, 9 HADS anxiety depression subscale indication nor months, all groups. Conclusion this RCT, treated an overall decrease scores up compared baseline. reported stable Cochlear implants appear be superior achieving partial complete resolution SSD. Clinical registration Netherlands Trial Register, www.onderzoekmetmensen.nl/nl/trial/26952 , NTR4457, CINGLE trial.

Язык: Английский

Процитировано

3
SoundModVR: Sound Modifications in Virtual Reality to Support People who are Deaf and Hard of Hearing DOI
Xinyun Cao, Dhruv Jain

Опубликована: Окт. 20, 2024

Язык: Английский

Процитировано

3
Enhancing balance and auditory function in bilateral vestibulopathy through otolithic vestibular stimulation: insights from a pilot study on cochlea-vestibular implant efficacy DOI Creative Commons
Ángel Ramos de Miguel, Morgana Sluydts, Juan C. Suárez‐Falcón

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Янв. 30, 2025

Introduction This study evaluates cochleovestibular implants (CVI) for improving auditory and vestibular function in patients with bilateral vestibulopathy severe-to-profound hearing loss. CVI uniquely combines stimulation, offering a potential solution dual impairments balance. Methods Ten underwent implantation. Auditory was assessed pure-tone audiometry (PTA) speech recognition at baseline, 3, 9 months post-implantation. Vestibular measured using the Dynamic Gait Index (DGI), Sensory Organization Test (SOT), posturography, Dizziness Handicap Inventory (DHI). Placebo-controlled tests verified stimulation specificity. Results outcomes showed PTA improvements from 78 dB HL preoperatively to 34 3 36 months, alongside gains. included significant DGI ( p < 0.05) SOT score increases (33% 68%, 0.05). DHI scores reflected reduced dizziness-related disability. Residual balance gains after device deactivation suggest neural adaptation, placebo confirmed Discussion effectively restores function, hearing, balance, quality of life. Neural plasticity likely supports long-term benefits. Future research should refine design protocols enhance further.

Язык: Английский

Процитировано

0
Candidate Key Proteins in Tinnitus—A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus DOI Open Access

Johann Gross,

Marlies Knipper, Birgit Mazurek

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1831 - 1831

Опубликована: Фев. 20, 2025

Proteins involved in synaptic transmission normal hearing, acoustic stimulation, and tinnitus were identified using protein–protein interaction (PPI) networks. The gene list for was compiled from the GeneCards database keywords “synaptic transmission” AND “inferior colliculus” “tinnitus” (Tin). For comparison, two lists built “auditory perception” (AP) “acoustic stimulation” (AS). STRING Cytoscape data analyzer used to identify top high-degree proteins (HDPs) corresponding high-score (HSIP). top1 key of AP AS processes are BDNF receptor NTRK2; top2 process PVALB, together with GAD1, CALB1, CALB2, which important balance excitation inhibition. In process, FOS, CREB1, EGR1, MAPK1, reflecting an activated state. Tin BDNF, NTRK3, NTF3; these associated proliferation differentiation neurons indicate remodeling IC. GFAP S100B, indicating a role astrocytes modulation transmission.

Язык: Английский

Процитировано

0