Journal of Neurology,
Год журнала:
2025,
Номер
272(5)
Опубликована: Апрель 17, 2025
Abstract
Background
Cerebellar
disease
may
result
in
Cognitive
Affective
Syndrome
(CCAS)
.
The
CCAS-Scale,
designed
to
screen
for
CCAS,
has
been
validated
English
Hoche
(Brain
141:248–270,
2018)
and
adapted
other
languages.
Methods
Here,
the
German
CCAS-Scale
Thieme
(Neurol
Res
Pract
2:39,
2020)
was
209
patients
with
cerebellar
disorders
232
healthy
controls.
Correction
formulas
outcome
parameters
[failed
test
items
(range:
1–10)
sum
raw
score
0–120)]
were
developed,
controlling
age,
education,
sex
effects.
Diagnostic
accuracy
reliability
assessed.
Results
improved
selectivity
controls,
reducing
false
positives
(failed
items:
40%;
score:
13%
vs.
original
method
2018):
67%),
while
maintaining
moderate
sensitivity
69%;
48%
87%).
Word
fluency
tests
differentiated
best
between
did
not.
Internal
consistency
(α
=
0.71)
acceptable.
Removal
of
word
worsened
it.
Retest
interrater
high
[intraclass
correlation
coefficients
(ICC):
0.77–0.95].
However,
these
ICCs
yielded
a
large
minimal
detectable
change
(MDC;
2.2–2.4
failed
items,
9.5–11.4
points)
patients,
limiting
use
follow-up
examinations.
Conclusion
correction
diagnostic
particularly
score.
Therefore,
we
recommend
using
corrected
evaluation
instead
uncorrected
number
proposed
originally
2018).
Some
however,
not
differentiate
well
controls
MDCs
large,
highlighting
need
refined
CCAS
assessment
instruments
as
progression
or
treatment
outcomes.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 29, 2024
Abstract
Post-COVID-19
syndrome
is
a
serious
complication
following
SARS-CoV-2
infection,
characterized
primarily
by
fatigue
and
cognitive
complaints.
Although
first
metabolic
structural
imaging
alterations
in
have
been
identified,
their
functional
consequences
remain
unknown.
Thus,
we
explored
the
impact
of
on
connectome
brain
providing
deeper
understanding
pathophysiological
mechanisms.
In
cross-sectional
observational
study,
resting-state
magnetic
resonance
data
66
patients
with
after
mild
infection
(mean
age
42.3
years,
57
female)
healthy
controls
42.1
38
mean
time
seven
months
acute
COVID-19
were
analysed
using
graph
theoretical
approach.
Network
features
quantified
measures
including
distance,
nodal
degree,
betweenness
Katz
centrality,
compared
between
both
groups.
Graph
correlated
clinical
quantifying
fatigue,
function,
affective
symptoms
sleep
disturbances.
Alterations
mainly
found
brainstem,
olfactory
cortex,
cingulate
thalamus
cerebellum
average
infection.
Additionally,
strong
correlations
severity,
functioning
daytime
sleepiness
from
scales
observed.
Our
study
confirms
relevance
changes
as
mediating
factors
for
persistent
improves
our
understanding.
Epigenomes,
Год журнала:
2024,
Номер
8(1), С. 4 - 4
Опубликована: Янв. 26, 2024
While
studying
myoblast
methylomes
and
transcriptomes,
we
found
that
CDH15
had
a
remarkable
preference
for
expression
in
both
myoblasts
cerebellum.
To
understand
how
widespread
such
relationship
was
its
epigenetic
biological
correlates,
systematically
looked
genes
with
similar
transcription
profiles
analyzed
their
DNA
methylation
chromatin
state
accessibility
many
different
cell
populations.
Twenty
were
expressed
preferentially
cerebellum
(Myob/Cbl
genes).
Some
shared
hypo-
or
hypermethylated
regions
Particularly
striking
ZNF556,
whose
promoter
is
hypomethylated
expressing
cells
but
highly
methylated
the
populations
do
not
express
gene.
In
reporter
gene
assays,
demonstrated
promoter’s
activity
sensitive.
The
atypical
epigenetics
of
ZNF556
may
have
originated
from
hypomethylation
selective
activation
sperm
progenitors
oocytes.
Five
Myob/Cbl
(KCNJ12,
ST8SIA5,
ZIC1,
VAX2,
EN2)
much
higher
RNA
levels
than
displayed
myoblast-specific
hypermethylation
upstream
and/or
downstream
promoters
downmodulate
expression.
Differential
associated
alternative
usage
MCF2L,
DOK7,
CNPY1,
ANK1.
PAX3,
LBX1,
EN2,
VAX2
encode
sequence-specific
factors,
which
likely
help
drive
specificity
other
genes.
This
study
extends
our
understanding
epigenetic/transcription
associations
related
to
differentiation
elucidate
relationships
between
signatures
muscular
dystrophies
cerebellar-linked
neuropathologies.
Journal of Neurochemistry,
Год журнала:
2024,
Номер
168(11), С. 3663 - 3684
Опубликована: Июль 29, 2024
The
neurotransmitter
glycine
is
an
agonist
at
the
strychnine-sensitive
receptors.
In
addition,
it
has
recently
been
discovered
to
act
two
new
receptors,
excitatory
receptor
and
metabotropic
receptor.
Glycine's
roles
have
most
extensively
investigated
in
spinal
cord,
where
known
play
essential
pain,
itch,
motor
function.
contrast,
less
about
supraspinal
glycinergic
functions,
their
contributions
pain
circuits
are
largely
unrecognized.
As
neurons
absent
from
cortical
regions,
a
clearer
understanding
of
how
modulates
could
reveal
pharmacological
targets.
This
review
aims
synthesize
published
research
on
glycine's
role
adult
brain,
highlighting
regions
signaling
may
modulate
responses.
was
achieved
through
scoping
methodology
identifying
several
key
circuitry
involved.
Therefore,
this
unveils
critical
gaps
for
potential
pain-associated
responses,
encouraging
researchers
consider
neurotransmission
more
widely
when
investigating
neural
mechanisms
pain.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
The
capacity
of
the
brain
to
compensate
for
insults
during
development
depends
on
type
cell
loss,
whereas
consequences
genetic
mutations
in
same
neurons
are
difficult
predict.
We
reveal
powerful
compensation
from
outside
cerebellum
when
excitatory
cerebellar
output
ablated
embryonically
and
demonstrate
that
minimum
requirement
these
is
motor
coordination
not
learning
social
behaviors.
In
contrast,
loss
homeobox
transcription
factors
Engrailed1/2
(EN1/2)
lineage
leads
additional
deficits
adult
spatial
working
memory,
despite
half
being
intact.
Diffusion
MRI
indicates
increased
thalamo-cortico-striatal
connectivity
En1/2
mutants,
showing
remaining
lacking
exert
adverse
effects
extracerebellar
circuits
regulating
select
non-motor
Thus,
an
absence
less
disruptive
than
having
mutations.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
The
advent
of
various
neuroimaging
methodologies
has
greatly
aided
in
the
conceptualization
large-scale
brain
networks
field
cognitive
neuroscience.
However,
there
is
inconsistency
across
studies
both
nomenclature
and
functional
entities
being
described.
There
a
need
for
unifying
framework
which
standardizes
terminology
while
also
bringing
analyses
results
into
same
reference
space.
Here
we
present
whole-brain
atlas
canonical
derived
from
more
than
100k
resting-state
fMRI
datasets.
These
data-driven
are
highly
replicable
datasets
as
well
multiple
spatial
scales.
We
have
organized,
labeled,
described
them
with
terms
familiar
to
fields
affective
neuroscience
order
optimize
their
utility
future
enhance
accessibility
new
findings.
benefits
this
not
limited
template-based
or
reference-guided
analyses,
but
extend
other
approaches
modalities,
such
those
using
blind
independent
component
analysis
(ICA).
Future
utilizing
will
contribute
greater
harmonization
standardization
research.
