Current Biology,
Год журнала:
2023,
Номер
33(16), С. 3436 - 3451.e7
Опубликована: Авг. 1, 2023
During
reward-based
learning
tasks,
animals
make
orofacial
movements
that
globally
influence
brain
activity
at
the
timings
of
reward
expectation
and
acquisition.
These
are
not
explicitly
instructed
typically
appear
along
with
goal-directed
behaviors.
Here,
we
show
reinforcing
optogenetic
stimulation
dopamine
neurons
in
ventral
tegmental
area
(oDAS)
mice
is
sufficient
to
induce
whiskers
nose
without
accompanying
Pavlovian
conditioning
a
sensory
cue
oDAS
elicited
cue-locked
oDAS-aligned
movements,
which
were
distinguishable
by
machine-learning
model.
Inhibition
or
knockout
D1
receptors
nucleus
accumbens
inhibited
oDAS-induced
motion
but
spared
motion,
suggesting
differential
regulation
these
two
types
motions.
In
contrast,
inactivation
whisker
primary
motor
cortex
(wM1)
abolished
both
movements.
We
found
specific
neuronal
populations
wM1
representing
either
Notably,
successfully
replicated
Our
results
thus
suggest
accumbal
D1-receptor-dependent
-independent
signals
converge
for
facilitating
distinct
uninstructed
during
task.
Fluctuations
in
arousal,
controlled
by
subcortical
neuromodulatory
systems,
continuously
shape
cortical
state,
with
profound
consequences
for
information
processing.
Yet,
how
arousal
signals
influence
population
activity
detail
has
so
far
only
been
characterized
a
few
selected
brain
regions.
Traditional
accounts
conceptualize
as
homogeneous
modulator
of
neural
across
the
cerebral
cortex.
Recent
insights,
however,
point
to
higher
specificity
effects
on
different
components
and
Here,
we
provide
comprehensive
account
relationships
between
fluctuations
neuronal
human
brain.
Exploiting
established
link
pupil
size
central
performed
concurrent
magnetoencephalographic
(MEG)
pupillographic
recordings
large
number
participants,
pooled
three
laboratories.
We
found
cascade
relative
peak
timing
spontaneous
dilations:
Decreases
low-frequency
(2–8
Hz)
temporal
lateral
frontal
cortex,
followed
increased
high-frequency
(>64
mid-frontal
regions,
monotonic
inverted
U
intermediate
frequency-range
(8–32
occipito-parietal
Pupil-linked
also
coincided
widespread
changes
structure
aperiodic
component
activity,
indicative
excitation-inhibition
balance
underlying
microcircuits.
Our
results
novel
basis
studying
modulation
cognitive
computations
circuits.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Июнь 13, 2019
Abstract
During
navigation,
rodents
continually
sample
the
environment
with
their
whiskers.
How
locomotion
modulates
neuronal
activity
in
somatosensory
cortex,
and
how
it
is
integrated
whisker-touch
remains
unclear.
Here,
we
compared
layer
2/3
(L2/3)
L5
of
barrel
cortex
using
calcium
imaging
mice
running
a
tactile
virtual
reality.
Both
layers
increase
during
concomitant
whisking,
absence
touch.
Fewer
neurons
are
modulated
by
whisking
alone.
Whereas
respond
transiently
to
wall-touch
running,
L2/3
show
sustained
activity.
Consistently,
encoding
running-with-touch
more
abundant
they
encode
run-speed
better
Few
across
were
also
sensitive
abrupt
perturbations
flow
running.
In
summary,
significantly
enhances
mainly
reporting
changes
touch
conditions
integrating
stimuli
PLoS Biology,
Год журнала:
2019,
Номер
17(10), С. e3000511 - e3000511
Опубликована: Окт. 11, 2019
Cognitive
processes
are
almost
exclusively
investigated
under
highly
controlled
settings
during
which
voluntary
body
movements
suppressed.
However,
recent
animal
work
suggests
differences
in
sensory
processing
between
movement
states
by
showing
drastically
changed
neural
responses
early
visual
areas
locomotion
and
stillness.
Does
also
modulate
cortical
activity
humans,
what
the
perceptual
consequences?
Our
study
shows
that
walking
increased
contrast-dependent
influence
of
peripheral
input
on
central
input.
This
increase
is
prevalent
stimulus-locked
electroencephalogram
(EEG)
(steady-state
evoked
potential
[SSVEP])
alongside
performance.
Ongoing
alpha
oscillations
(approximately
10
Hz)
further
positively
correlated
with
walking-induced
changes
SSVEP
amplitude,
indicating
involvement
an
altered
inhibitory
process
walking.
The
results
predicted
leads
to
A
second
indeed
showed
contrast
sensitivity
for
compared
stimuli
when
subjects
were
complementary
neurophysiological
behavioural
evidence
corroborating
findings
a
change
neuronal
humans.
That
modulation
due
linked
specific
extends
existing
work.
Annual Review of Neuroscience,
Год журнала:
2021,
Номер
44(1), С. 517 - 546
Опубликована: Апрель 29, 2021
The
mouse,
as
a
model
organism
to
study
the
brain,
gives
us
unprecedented
experimental
access
mammalian
cerebral
cortex.
By
determining
cortex's
cellular
composition,
revealing
interaction
between
its
different
components,
and
systematically
perturbing
these
we
are
obtaining
mechanistic
insight
into
some
of
most
basic
properties
cortical
function.
In
this
review,
describe
recent
advances
in
our
understanding
how
circuits
neurons
implement
computations,
revealed
by
mouse
primary
visual
Further,
discuss
studying
has
broadened
range
computations
performed
Finally,
address
future
approaches
will
fulfill
promise
elucidating
fundamental
operations
Current Biology,
Год журнала:
2020,
Номер
30(24), С. 4944 - 4955.e7
Опубликована: Окт. 23, 2020
In
many
behavioral
tasks,
cortex
enters
a
desynchronized
state
where
low-frequency
fluctuations
in
population
activity
are
suppressed.
The
precise
correlates
of
desynchronization
and
its
global
organization
unclear.
One
hypothesis
holds
that
enhances
stimulus
coding
the
relevant
sensory
cortex.
Another
reflects
arousal,
such
as
task
engagement.
Here,
we
trained
mice
on
tasks
engagement
could
be
distinguished
from
accuracy.
Using
widefield
calcium
imaging,
found
performance-related
was
correlated
better
with
than
Consistent
this
link
between
engagement,
rewards
had
long-lasting
desynchronizing
effect.
To
determine
whether
engagement-related
changes
depended
modality,
visual
auditory
both
cases
global,
including
regions
somatomotor
We
conclude
variations
predominately
related
to
Neuron,
Год журнала:
2022,
Номер
110(19), С. 3064 - 3075
Опубликована: Июль 20, 2022
Sensory
areas
are
spontaneously
active
in
the
absence
of
sensory
stimuli.
This
spontaneous
activity
has
long
been
studied;
however,
its
functional
role
remains
largely
unknown.
Recent
advances
technology,
allowing
large-scale
neural
recordings
awake
and
behaving
animal,
have
transformed
our
understanding
activity.
Studies
using
these
discovered
high-dimensional
patterns,
correlation
between
behavior,
dissimilarity
sensory-driven
patterns.
These
findings
supported
by
evidence
from
developing
animals,
where
a
transition
toward
characteristics
is
observed
as
circuit
matures,
well
mature
animals
across
species.
newly
revealed
call
for
formulation
new
computation.
Neuron,
Год журнала:
2022,
Номер
110(13), С. 2124 - 2138.e8
Опубликована: Май 6, 2022
Flexible
mapping
between
activity
in
sensory
systems
and
movement
parameters
is
a
hallmark
of
motor
control.
This
flexibility
depends
on
the
continuous
comparison
short-term
postural
dynamics
longer-term
goals
an
animal,
thereby
necessitating
neural
mechanisms
that
can
operate
across
multiple
timescales.
To
understand
how
such
body-brain
interactions
emerge
timescales
to
control
movement,
we
performed
whole-cell
patch
recordings
from
visual
neurons
involved
course
Drosophila.
We
show
leg
mechanosensory
cells,
propagating
via
specific
ascending
neurons,
critical
for
stride-by-stride
steering
adjustments
driven
by
circuit,
and,
at
longer
timescales,
it
provides
information
about
moving
body's
state
flexibly
recruit
circuit
Thus,
our
findings
demonstrate
presence
elegant
stride-based
mechanism
operating
context-dependent
propose
this
functions
as
general
basis
adaptive
locomotion.
