Emergence and Developmental Roles of the Cerebrospinal Fluid System DOI Creative Commons
Ryann M. Fame, Maria K. Lehtinen

Developmental Cell, Год журнала: 2020, Номер 52(3), С. 261 - 275

Опубликована: Фев. 1, 2020

We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function. More than a protective cushion and sink for waste, the CSF is an integral CNS component with dynamic diverse roles emerging in parallel developing CNS. This review examines current understanding about early its maturation during development discusses open questions field. focus on developmental changes ventricular system sources (including neural progenitors choroid plexus). also discuss concepts related to of dynamics including flow, perivascular transport, drainage, barriers.

Язык: Английский

An in vivo model of functional and vascularized human brain organoids DOI
Abed AlFatah Mansour, J. Tiago Gonçalves,

Cooper W Bloyd

и другие.

Nature Biotechnology, Год журнала: 2018, Номер 36(5), С. 432 - 441

Опубликована: Апрель 16, 2018

Язык: Английский

Процитировано

1034

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development DOI Creative Commons
Cleber A. Trujillo, Richard Gao, Priscilla D. Negraes

и другие.

Cell stem cell, Год журнала: 2019, Номер 25(4), С. 558 - 569.e7

Опубликована: Авг. 29, 2019

Язык: Английский

Процитировано

735

Fused cerebral organoids model interactions between brain regions DOI
Joshua A. Bagley, Daniel Reumann, Shan Bian

и другие.

Nature Methods, Год журнала: 2017, Номер 14(7), С. 743 - 751

Опубликована: Май 10, 2017

Язык: Английский

Процитировано

685

The use of brain organoids to investigate neural development and disease DOI
Elizabeth Di Lullo, Arnold R. Kriegstein

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(10), С. 573 - 584

Опубликована: Сен. 7, 2017

Язык: Английский

Процитировано

672

Organoid single-cell genomic atlas uncovers human-specific features of brain development DOI
Sabina Kanton, Michael James Boyle, Zhisong He

и другие.

Nature, Год журнала: 2019, Номер 574(7778), С. 418 - 422

Опубликована: Окт. 16, 2019

Язык: Английский

Процитировано

654

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output DOI
Stefano L. Giandomenico, Susanna B. Mierau,

George M. Gibbons

и другие.

Nature Neuroscience, Год журнала: 2019, Номер 22(4), С. 669 - 679

Опубликована: Март 18, 2019

Язык: Английский

Процитировано

526

Microglia innately develop within cerebral organoids DOI Creative Commons

Paul R. Ormel,

Renata Vieira de Sá, Emma J. van Bodegraven

и другие.

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Окт. 3, 2018

Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human brain. The current consensus is cerebral consist of cells derived from neuroectodermal lineage. This limits their value and applicability, as mesodermal-derived microglia important players in neural development disease. Remarkably, here we show innately develop within a organoid model display characteristic ramified morphology. transcriptome response inflammatory stimulation these organoid-grown closely mimic adult acutely isolated post mortem brain tissue. In addition, mediate phagocytosis synaptic material detected inside them. all, our characterizes microglia-containing represents valuable tool for studying interplay between microglia, macroglia, neurons

Язык: Английский

Процитировано

514

Tissue clearing and its applications in neuroscience DOI Open Access
Hiroki R. Ueda, Ali Ertürk,

Kwanghun Chung

и другие.

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(2), С. 61 - 79

Опубликована: Янв. 2, 2020

Язык: Английский

Процитировано

504

The rise of three-dimensional human brain cultures DOI
Sergiu P. Paşca

Nature, Год журнала: 2018, Номер 553(7689), С. 437 - 445

Опубликована: Янв. 1, 2018

Язык: Английский

Процитировано

437

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection DOI Creative Commons
Momoko Watanabe, Jessie E. Buth, Neda Vishlaghi

и другие.

Cell Reports, Год журнала: 2017, Номер 21(2), С. 517 - 532

Опубликована: Окт. 1, 2017

Язык: Английский

Процитировано

362