Developmental Cell,
Journal Year:
2020,
Volume and Issue:
52(3), P. 261 - 275
Published: Feb. 1, 2020
We
summarize
recent
work
illuminating
how
cerebrospinal
fluid
(CSF)
regulates
brain
function.
More
than
a
protective
cushion
and
sink
for
waste,
the
CSF
is
an
integral
CNS
component
with
dynamic
diverse
roles
emerging
in
parallel
developing
CNS.
This
review
examines
current
understanding
about
early
its
maturation
during
development
discusses
open
questions
field.
focus
on
developmental
changes
ventricular
system
sources
(including
neural
progenitors
choroid
plexus).
also
discuss
concepts
related
to
of
dynamics
including
flow,
perivascular
transport,
drainage,
barriers.
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Oct. 3, 2018
Cerebral
organoids
are
3D
stem
cell-derived
models
that
can
be
utilized
to
study
the
human
brain.
The
current
consensus
is
cerebral
consist
of
cells
derived
from
neuroectodermal
lineage.
This
limits
their
value
and
applicability,
as
mesodermal-derived
microglia
important
players
in
neural
development
disease.
Remarkably,
here
we
show
innately
develop
within
a
organoid
model
display
characteristic
ramified
morphology.
transcriptome
response
inflammatory
stimulation
these
organoid-grown
closely
mimic
adult
acutely
isolated
post
mortem
brain
tissue.
In
addition,
mediate
phagocytosis
synaptic
material
detected
inside
them.
all,
our
characterizes
microglia-containing
represents
valuable
tool
for
studying
interplay
between
microglia,
macroglia,
neurons
