Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1871(2), С. 167546 - 167546
Опубликована: Окт. 31, 2024
Язык: Английский
Viruses, Год журнала: 2024, Номер 16(7), С. 1161 - 1161
Опубликована: Июль 19, 2024
Mitochondria are key orchestrators of antiviral responses that serve as platforms for the assembly and activation innate immune-signaling complexes. In response to viral infection, mitochondria can be triggered release immune-stimulatory molecules boost interferon production. These same released by damaged induce pathogenic, antiviral-like immune in absence infection. This review explores how members tripartite motif-containing (TRIM) protein family, which recognized their roles defense, regulate mitochondria-based activation. TRIMs essential components signal transduction pathways function directly acting restriction factors. carry out conceptually similar activities when controlling related mitochondria. First, they modulate activated mitochondrial molecules. Second, co-ordinate direct removal associated immune-activating factors through mitophagy. insights broaden scope TRIM actions immunity may implicate diseases with mitochondria-derived inflammation.
Язык: Английский
Процитировано
3
Cells, Год журнала: 2025, Номер 14(4), С. 304 - 304
Опубликована: Фев. 18, 2025
The IκB kinase (IKK) complex plays a central role in many signaling pathways that activate NF-κB, which turns on battery of genes important for immune response, inflammation, and cancer development. Ubiquitination is one the most prevalent post-translational modifications proteins best known targeting substrates proteasomal degradation. investigations NF-κB pathway primed unveiling non-degradative roles protein ubiquitination. NF-κB-essential modulator (NEMO) IKK regulatory subunit essential activation by diverse intrinsic extrinsic stimuli. studies centered NEMO as polyubiquitin-binding have remarkably advanced understandings how transmits signals to laid foundation determining molecular events demonstrating ubiquitination major driving element activation. Furthermore, these largely solved enigma can be activated employ distinct sets intermediaries transmitting signals. NEMO-related include optineurin, ABIN1, ABIN2, ABIN3, CEP55, ubiquitin chain receptors, play key sensing embodied different topologies polyubiquitin chains variety cellular processes body responses. Studies multifaceted promoted understanding about functions intracellular signaling, trafficking, proteostasis, DNA damage cell cycle control. In this review, I will also discuss dysfunction family protein-mediated associated with various diseases, including disorders, neurodegenerative cancer, microbial virulence factors target induce pathogenesis or manipulate host response. A profound bases valuable developing tailored approaches therapeutic purposes.
Язык: Английский
Процитировано
0
BIOspektrum, Год журнала: 2025, Номер 31(1), С. 32 - 35
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5110 - 5110
Опубликована: Май 26, 2025
Penaeus vannamei hemocyanin (PvHMC) exhibits multifunctional roles in immunity, often mediated by various post-translational modifications. While linear ubiquitination catalyzed LUBAC mammals regulates immune signaling, its role crustacean immunity remains unclear. Here, we investigated the regulatory mechanism of PvHMC an E3 ligase PvLUBEL (a HOIP homolog), with emphasis on shrimp defending against diverse pathogens. We detected multiple tissues, including hemocytes and hepatopancreas. During Vibrio parahaemolyticus infection, expression level were suppressed, whereas infection white spot syndrome virus (WSSV) led to their upregulation. Structural analyses revealed that PvLUBEL, which shares a conserved RING-IBR-RING (RBR) domain mammalian HOIP, serves as catalytic subunit. Notably, inhibition via HOIPIN-1 covalent inhibitor) or RNA interference (RNAi) significantly reduced ubiquitination, thereby increasing pathogen proliferation decreasing host survival. These findings unveil novel PvLUBEL-mediated underpins response aquaculture
Язык: Английский
Процитировано
0
Cell Stress and Chaperones, Год журнала: 2023, Номер 28(6), С. 811 - 820
Опубликована: Авг. 29, 2023
The experimental myocardial infarction (MI) model originating from isoproterenol (ISO) is frequently preferred in research due to its similarity MI-induced damage humans. Beneficial effects of L-arginine (L-Arg), a semi-essential amino acid, cardiovascular diseases have been shown many studies. This study was carried out determine whether L-Arg pre-intervention has protective on heart tissue the MI model. 28 rats used were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion all applications, cardiac markers serum biochemical, histopathological, immunohistochemical examinations tissues performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, apoptosis increased In addition, administration ISO deregulated OTULIN levels mitochondrial dynamics tissue. However, showed significant effect against changes ISO-induced MI. supplementation with cardioprotective may reduce risks possible pathophysiological processes
Язык: Английский
Процитировано
6
Cell Reports, Год журнала: 2024, Номер 43(8), С. 114545 - 114545
Опубликована: Июль 23, 2024
Язык: Английский
Процитировано
2
Medicine, Год журнала: 2023, Номер 102(32), С. e34540 - e34540
Опубликована: Авг. 11, 2023
Hyperuricemia nephropathy, also known as gouty refers to renal damage induced by hyperuricemia caused excessive production of serum uric acid or low excretion acid. the persistence symptoms will lead changes in tubular phenotype and accelerate progress fibrosis. The existence progressive aggravation bring a heavy burden patients, their families society, affect quality life reduce well-being. With increase reports on importance related signal pathways pathogenesis nephropathy is becoming more obvious, but most studies are limited upper lower mediating relationship between 1 2 pathways. research comprehensiveness breadth crosstalk limited. By synthesizing results recent years, this paper explore specific mechanism provide new ideas methods for treatment based variety pathway personal prospects.
Язык: Английский
Процитировано
4
Journal of Trace Elements in Medicine and Biology, Год журнала: 2024, Номер 84, С. 127455 - 127455
Опубликована: Апрель 15, 2024
Язык: Английский
Процитировано
1
Reproductive Sciences, Год журнала: 2024, Номер 31(8), С. 2433 - 2446
Опубликована: Апрель 24, 2024
Abstract One of the adverse effects antineoplastic drug cisplatin (CS) is damage to testicular tissue. This study aimed examine potential therapeutic effect thymoquinone (TQ), a strong antioxidant, against caused by CS. In experiment, 28 rats were used, and randomly divided into four groups: control ( n = 7), CS + TQ 7). The experiment was called off after all treatments finished on day 15. Blood serum tissues utilized for biochemical, histological, immunohistochemical, mRNA expression, gene protein investigations. testosterone level decreased oxidative stress, histopathological damage, dysregulation in mitochondrial dynamics, inflammation apoptotic cells increased tissue due administration. supplementation showed anti-inflammatory, anti-apoptotic response CS-induced damage. addition, contributed reduction toxic regulating TNF-α/OTULIN/NF-κB pathway. may be strategy axis, inhibiting inflammation, apoptosis.
Язык: Английский
Процитировано
1
Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)
Опубликована: Ноя. 28, 2023
Abstract Linear ubiquitination is a distinct type of that involves attaching head-to-tail polyubiquitin chain to substrate protein. Early studies found linear ubiquitin chains are essential for the TNFα- and IL-1-mediated NF-κB signaling pathways. However, recent have discovered at least sixteen substrates, which exhibit broader activity than expected mediate many other pathways beyond signaling. Dysregulation in these has been linked types cancers, such as lymphoma, liver cancer, breast cancer. Since discovery ubiquitin, extensive effort made delineate molecular mechanisms how dysregulation causes tumorigenesis cancer development. In this review, we highlight newly ubiquitination-mediated pathways, advances role different development inhibitors.
Язык: Английский
Процитировано
3