Archives of Microbiology, Год журнала: 2025, Номер 207(4)
Опубликована: Март 4, 2025
Язык: Английский
Frontiers in Science, Год журнала: 2024, Номер 2
Опубликована: Апрель 4, 2024
Global warming and climate change have increased the pollen burden frequency intensity of wildfires, sand dust storms, thunderstorms, heatwaves—with concomitant increases in air pollution, heat stress, flooding. These environmental stressors alter human exposome trigger complex immune responses. In parallel, pollutants, allergens, other factors increase risks skin mucosal barrier disruption microbial dysbiosis, while a loss biodiversity reduced exposure to diversity impairs tolerogenic development. The resulting dysregulation is contributing an immune-mediated diseases such as asthma allergic diseases, autoimmune cancer. It now abundantly clear that multisectoral, multidisciplinary, transborder efforts based on Planetary Health One approaches (which consider dependence health environment natural ecosystems) are urgently needed adapt mitigate effects change. Key actions include reducing emissions improving quality (through fossil fuel use), providing safe housing (e.g., weatherization), diets (i.e., diversity) agricultural practices, increasing green spaces. There also pressing need for collaborative, multidisciplinary research better understand pathophysiology context New data science techniques, biomarkers, economic models should be used measure impact disease, inform mitigation adaptation efforts, evaluate their effectiveness. Justice, equity, diversity, inclusion (JEDI) considerations integral these address disparities
Язык: Английский
Процитировано
24
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 139962 - 139962
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3148 - 3148
Опубликована: Март 28, 2025
Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing
Язык: Английский
Процитировано
3
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Фев. 22, 2024
Abstract Intestinal microbiota plays an indispensable role in the host's innate immune system, which may be related to occurrence of many autoimmune diseases. Hashimoto thyroiditis (HT) is one most common diseases, and there plenty evidence indicating that HT genetics environmental triggers, but specific mechanism has not been proven clearly. Significantly, composition abundance intestinal patients with have obvious difference. This phenomenon led us think about whether can affect progress through some mechanisms. By summarizing potential microflora regulating thyroiditis, this article explores possibility improving by summarizes relevant biomarkers as therapeutic targets, provide new ideas for clinical diagnosis treatment thyroiditis.
Язык: Английский
Процитировано
12
Psychiatry Research, Год журнала: 2024, Номер 336, С. 115914 - 115914
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
10
Frontiers in Veterinary Science, Год журнала: 2025, Номер 11
Опубликована: Янв. 10, 2025
The residual black wolfberry fruit (RBWF) is rich in nutrients and contains a diverse range of active substances, which may offer viable alternative to antibiotics. This experiment was conducted investigate the impact varying levels RBWF on growth performance rumen microorganisms fattening sheep, quantify its economic benefits. In this experiment, 40 three-month-old male Duolang sheep with an average weight 29.85 kg, selected for their propensity gain weight, were randomly assigned one four groups, ten each group. To end, group fed different proportion (0%, 2%, 5%, 8%), fluid samples collected detect differences fermentation parameters microbial structure. findings indicate that dry matter intake, OM NDF apparent digestibility H2 found be significantly higher than those observed other groups (P < 0.05). concentration volatile fatty acids (VFAs), including acetate, propionate, iso-butyrate, butyrate iso-valerate, demonstrated linear increase supplementation diet dominant bacteria identified as Prevotella, Christensenellaceae R7 group, NK4A214 Ruminococcus, Rikenellaceae RC9 gut Compared CK relative abundance unclassified Prevotellaceae Lachnospiraceae NK3A20 experimental increased degrees. gross profit groups. conclusion, has been enhance optimise parameters, ultimately profit, 5 % best.
Язык: Английский
Процитировано
2
Food Chemistry, Год журнала: 2025, Номер unknown, С. 143109 - 143109
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Molecular Metabolism, Год журнала: 2023, Номер 77, С. 101797 - 101797
Опубликована: Сен. 12, 2023
Polyphenols have health-promoting effects, such as improving insulin resistance. Isoxanthohumol (IX), a prenylated flavonoid found in beer hops, has been suggested to reduce obesity and resistance; however, the mechanism remains unknown.High-fat diet-fed mice were administered IX. We analyzed glucose metabolism, gene expression profiles histology of liver, epididymal adipose tissue colon. Lipase activity, fecal lipid plasma metabolomic analysis assessed. Fecal 16s rRNA sequencing was obtained selected bacterial species used for vitro studies. microbiota transplantation monocolonization conducted antibiotic-treated or germ-free (GF) mice.The administration IX lowered weight gain, decreased steatohepatitis improved metabolism. Mechanistically, inhibited pancreatic lipase activity absorption by decreasing fatty acid transporter CD36 small intestine, which confirmed increased excretion feces. markers intestinal barrier function, including thickening mucin layer increasing caludin-1, tight-junction related protein In contrast, effects nullified antibiotics. As revealed using 16S sequencing, microbial community structure changed with significant increase abundance Akkermansia muciniphila IX-treated group. An anaerobic chamber study showed that selectively promoted growth A. while exhibiting antimicrobial against some Bacteroides Clostridium species. To further explore direct effect on we monocolonized either thetaiotaomicron GF mice. jejunum levels multiple classes acids determined analysis.Our demonstrated prevents enhances metabolism inhibiting dietary fat absorption. This is linked suppressing shifts composition, notably an muciniphila. These highlight new treatment strategies preventing metabolic syndrome boosting gut food components.
Язык: Английский
Процитировано
19
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 25, 2024
Microplastics (MPs), defined as plastic particles smaller than 5 mm, are increasingly recognized environmental contaminants with potential health risks. These emerge breakdown products of larger plastics and omnipresent in marine, freshwater, terrestrial ecosystems. They primarily composed polymers such polyethylene, polypropylene, polystyrene, additives that enhance their performance. MPs also adsorb harmful chemicals like persistent organic pollutants heavy metals, posing risks to human health. Human exposure occurs mainly through ingestion inhalation, detected food products, water, even the air. have been shown accumulate gastrointestinal tract, disrupting gut microbiome, causing dysbiosis-a imbalance between beneficial bacteria. This disruption has linked various issues, including disorders, systemic inflammation, chronic diseases. Furthermore, gut-brain axis may be affected, neuroinflammatory consequences. As research continues unravel impacts MP exposure, understanding mechanisms accumulation broader implications on is crucial. review highlights effects health, emphasizing impact microbiome. We discuss connections cardiometabolic inflammatory diseases, disorders related Gut-Brain Axis. By synthesizing latest research, this work sheds light silent yet pervasive threat posed by underscores importance further studies understand fully.
Язык: Английский
Процитировано
9
World Journal of Gastroenterology, Год журнала: 2024, Номер 30(16), С. 2249 - 2257
Опубликована: Апрель 26, 2024
This study aimed to identify characteristic gut genera in obese and normal-weight children (8-12 years old) using 16S rDNA sequencing. The research provide insights for mechanistic studies prevention strategies childhood obesity. Thirty thirty age- sex-matched were included. Questionnaires body measurements collected, fecal samples underwent Significant differences mass index (BMI) body-fat percentage observed between the groups. Analysis of microbiota diversity revealed lower α-diversity children. Di-fferences composition found two
Язык: Английский
Процитировано
8