Co-morbidity of PTSD and immune system dysfunction: opportunities for treatment

Current Opinion in Pharmacology, Год журнала: 2016, Номер 29, С. 104 - 110

Опубликована: Июль 30, 2016

Язык: Английский

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Posttraumatic stress disorder symptoms in newly diagnosed patients with head and neck cancer and their partners

Head & Neck, Год журнала: 2014, Номер 37(9), С. 1282 - 1289

Опубликована: Май 12, 2014

Background Head and neck cancer is a life-threatening illness requiring aversive treatments. Despite clear potential for posttraumatic stress disorder (PTSD) symptoms in both patients their partners, research scant. Methods Newly diagnosed partners (number of dyads = 42) completed questionnaires to assess PTSD, anxiety, depression, as well demographic, medical, attitudinal variables. Results Partners had higher average levels PTSD than (p .023). More (28.6%) met criteria estimated caseness did (11.9%). There were no significant differences other anxiety or depression symptoms. Perceived threat disease appeared be stronger correlate symptom medical variables partners. Conclusion A diagnosis head elicits patients, even among Identified correlates distress, including perceived disease, are intervention targets. © 2014 Wiley Periodicals, Inc. Neck 37: 1282–1289, 2015

Язык: Английский

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Medically Related Post-traumatic Stress in Children and Adolescents with Congenital Heart Defects

Frontiers in Pediatrics, Год журнала: 2017, Номер 5

Опубликована: Фев. 13, 2017

Children and adolescents with a congenital heart defect (ConHD) frequently undergo painful or frightening medical procedures hospitalizations. They often need multiple invasive at very young age require regular checkups during their entire life. From other pediatric populations it is known that these kind of experiences can result in acute stress reactions even posttraumatic disorder (PTSD) the long-term. PTSD also subthreshold lead to serious (psychosocial) impairment. However, limited information available about children ConHD. Therefore, aim this review provide summary current literature on ConHD describing prevalence its predictors/correlates. This indicates range 12-31% undergoing cardiac surgery develops PTSD. A 12-14% shows elevated symptoms (PTSS). These findings are comparable those hospitalized without Noteworthy, most studies used varying self-report questionnaires measure only one study semi-structured interview. Although all point same direction PTSS, systematic research necessary be able draw firm conclusions. At present, as far we know, clinics treating patients there no screening for In reviewed literature, strong consensus PTSS (preventive) psychological care urgently needed

Язык: Английский

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Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain

Molecular Pain, Год журнала: 2016, Номер 12

Опубликована: Янв. 1, 2016

The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess inflammatory immune activities in hippocampus involved progression both pain. Considering microglia are substrates initiation propagation neuroimmune response, we hypothesized stress-induced activation hippocampal may contribute to pathogenesis disorder-pain comorbidity. We showed rats exposed single prolonged stress, established model, exhibited persistent mechanical allodynia anxiety-like behavior, which were accompanied by increased secretion pro-inflammatory cytokines hippocampus. Correlation analyses was significantly correlated with behavior. Our data also intraperitoneal intra-hippocampal injection minocycline suppressed accumulation hippocampus, attenuated Taken together, present study suggests serve as a critical mechanistic link comorbid relationship between novel concept introduces possibility cotreating disorder.

Язык: Английский

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Childhood trauma, the stress response and metabolic syndrome: A focus on DNA methylation

European Journal of Neuroscience, Год журнала: 2021, Номер 55(9-10), С. 2253 - 2296

Опубликована: Июнь 25, 2021

Childhood trauma (CT) is well established as a potent risk factor for the development of mental disorders. However, potential adverse early experiences to exert chronic and profound effects on physical health, including aberrant metabolic phenotypes, has only been more recently explored. Among these consequences syndrome (MetS), which characterised by at least three five related cardiometabolic traits: hypertension, insulin resistance/hyperglycaemia, raised triglycerides, low high-density lipoprotein central obesity. The deleterious CT health outcomes may be partially attributable dysregulation hypothalamic-pituitary-adrenal (HPA) axis, coordinates response stress, consequent fostering pro-inflammatory environment. Epigenetic tags, such DNA methylation, are sensitive environmental influences provide means whereby can biologically embedded persist into adulthood affect well-being. methylome regulates transcription genes involved in stress response, metabolism inflammation. This narrative review examines evidence methylation MetS order identify shared neuroendocrine immune correlates that mediate increased following exposure. Our specifically highlights differential FKBP5, gene encodes FK506-binding protein 51 pleiotropic responding, inflammation energy metabolism, candidate understand molecular aetiology underlying CT-associated risk.

Язык: Английский

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Stress-induced pro- and anti-inflammatory cytokine concentrations in female PTSD and depressive patients

Translational Psychiatry, Год журнала: 2022, Номер 12(1)

Опубликована: Апрель 14, 2022

Alterations of the hypothalamus pituitary-axis on one hand and heightened rates somatic diseases mortality other are consistently found for PTSD MDD patients. A possible link between these factors might be immune system, in particular pro- anti-inflammatory cytokines. 'low-grade inflammation' patients was found, whereas influence acute stress role cytokines rarely examined. In this study, 17 female participated Trier social test while serum cytokine levels (IL-6, IL-10) were assessed. Cytokine compared with depressive (n = 18) healthy controls 18). Group differences assessed using a 3 (group) x 8 (time: -15, -1, +1, +10, +20, +30, +45, +60 min) ANCOVA repeated measures baseline values as covariates. There no group difference regarding IL-6 (p 0.920) but showed significantly higher IL-10 < 0.001, d 0.16) 0.38). Under stress, did not show widely elevated an increase IL-10. Therefore, seems to promote imbalance indicate hyperreactive response. This should considered future studies further understand system response diseases.

Язык: Английский

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PTSD in solid organ transplant recipients: Current understanding and future implications

Pediatric Transplantation, Год журнала: 2015, Номер 20(1), С. 23 - 33

Опубликована: Дек. 9, 2015

Abstract PTSS are quite prevalent in transplant recipients, although full‐scale PTSD may not be that common. Those symptoms have been linked to poor outcomes, perhaps owing non‐adherence medications and other recommendations, brought about by the avoidance dimension of / construct (patients avoid taking their because they serve as reminder emotionally traumatic event—the transplant). It is possible treat via specific psychotherapeutic techniques, treatment has shown safe likely effective populations. Therefore, practitioners who recipients should familiar with presentation those symptoms. This manuscript provides a systematic literature review pediatric setting, synthesis available research findings, suggestions for current care future research.

Язык: Английский

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Trauma training: Competencies, initiatives, and resources.

Psychotherapy, Год журнала: 2019, Номер 56(3), С. 409 - 421

Опубликована: Июль 8, 2019

Traumatic stress is currently not a required component of the standard curricula in graduate-level education clinical and counseling psychology. However, due to high prevalence trauma its potentially deleterious physical mental health effects general populations, it imperative that psychology graduate students practitioners understand relevance their clients' lives impact research. A comprehensive model trauma-focused empirically informed competencies (knowledge, skills, attitudes) was developed at national consensus conference 2013 approved by American Psychological Association 2015 as part organization's training policy. These predated Association's Posttraumatic Stress Disorder Guidelines, provided about scientific, theoretical, ethical, professional foundational knowledge, attitudes for all trauma-informed practice, solely treatment. The two endeavors are related synergistic, but separate. Intended guide programs' curriculum development psychologists' self-monitoring, serve aspirational goals psychologists. Training issues these other discussed. Perhaps, most importantly, scientific literature on constantly evolving, thus embracing an ever-evolving lifelong-learning approach essential. (PsycINFO Database Record (c) 2019 APA, rights reserved).

Язык: Английский

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COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Март 15, 2021

Abstract Psychiatric symptoms are seen in some COVID-19 patients, as direct or indirect sequelae, but it is unclear whether SARS-CoV-2 infection interacts with underlying neuronal psychiatric susceptibilities. Such interactions might arise from immune responses, of neurons themselves may reflect social-psychological causes. To clarify this we sought the key gene expression pathways altered also affected bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia, since identify interaction that could be treatment targets. We performed large scale comparisons whole transcriptome data factor transcript peripheral blood mononuclear cells (PBMC) patients disorders. analysed genome-wide association study (GWAS) for symptomatic comparing GWAS whole-genome sequence PTSD schizophrenia patients. These studies revealed signalling ontology shared by three Finally, co-expression network analyses identified clusters common to conditions. had system profiles overlapped those From identified, were most highly correlated COVID-19, perhaps consistent stress-immune PTSD. inflammatory exacerbate disorders, which support usage anti-inflammatory medications these It highlights potential clinical application multi-level dataset difficult-to-treat disorders pandemic.

Язык: Английский

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Spinal activation of alpha7-nicotinic acetylcholine receptor attenuates posttraumatic stress disorder-related chronic pain via suppression of glial activation

Neuroscience, Год журнала: 2016, Номер 344, С. 243 - 254

Опубликована: Дек. 28, 2016

Язык: Английский

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