Biology,
Год журнала:
2025,
Номер
14(2), С. 202 - 202
Опубликована: Фев. 14, 2025
Centella
asiatica,
a
traditional
medicinal
plant,
possesses
potent
antioxidant
activity
and
may
therefore
prevent
cellular
aging
exert
antiapoptotic
effects.
However,
these
effects
remain
to
be
fully
elucidated.
This
study
aimed
investigate
the
protective
of
C.
asiatica
extract
against
senescence
apoptosis
caused
by
hydrogen
peroxide
(H2O2)-induced
oxidative
stress
in
human
epidermal
keratinocytes
(HaCaT
cells).
To
evaluate
H2O2
on
HaCaT
cells,
we
measured
cell
viability
as
marker
death;
reactive
oxygen
species
(ROS),
radical
scavenging,
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPx),
catalase
activities
markers
stress;
senescence-associated
β-galactosidase
(SA-β-gal)
senescence;
caspase-3/9
apoptotic
cells
apoptosis.
induced
death
(decreased
viability),
(increased
ROS
activity,
decreased
SOD,
GPx,
activities),
SA-β-gal
activity),
early/late
increased
activities).
significantly
all
H2O2-induced
death,
stress,
senescence,
apoptosis,
suggesting
its
ability
through
activity.
mechanism
action
contribute
prevention
improvement
skin
aging.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(5), С. 2410 - 2410
Опубликована: Фев. 27, 2021
Mesenchymal
stem
cells
(MSCs)
are
multipotent
derived
from
adult
cells.
Primary
MSCs
can
be
obtained
diverse
sources,
including
bone
marrow,
adipose
tissue,
and
umbilical
cord
blood.
Recently,
have
been
recognized
as
therapeutic
agents
for
skin
regeneration
rejuvenation.
The
damaged
by
wounds,
caused
cutting
or
breaking
of
the
burns.
Moreover,
aging
is
a
process
that
occurs
naturally
but
worsened
environmental
pollution,
exposure
to
ultraviolet
radiation,
alcohol
consumption,
tobacco
use,
undernourishment.
healing
capacities
applied
in
aged
skin.
In
regeneration,
increase
cell
proliferation
neovascularization,
decrease
inflammation
injury
lesions.
rejuvenation,
lead
production
collagen
elastic
fibers,
inhibition
metalloproteinase
activation,
promote
protection
radiation-induced
senescence.
this
review,
we
focus
on
how
MSC-derived
molecules
improve
diseased
Additionally,
emphasize
induced
pluripotent
(iPSC)-derived
potentially
advanced
MSCs,
which
suitable
therapy.
Chemistry and Physics of Lipids,
Год журнала:
2021,
Номер
236, С. 105055 - 105055
Опубликована: Фев. 6, 2021
Our
skin
is
the
interface
between
us
and
our
environment
–
a
flexible
barrier
that
has
evolved
for
protection,
immunity,
regulation
sensation.
Once
regarded
as
inert,
we
now
know
it
dynamic
environment.
Skin
lipids
are
crucial
to
structure
function
of
skin.
From
deep
in
hypodermis,
through
ceramide-rich
epidermis,
surface,
there
vast
array
different
with
important
roles
play.
This
review
firstly
discusses
lipid
composition
human
secondly,
changes
have
been
found
diseases.
Further
research
into
facilitated
by
ever-improving
methodologies
will
no
doubt
generate
new
knowledge,
paving
way
diagnosis,
prevention
treatment
disorders
Phytomedicine,
Год журнала:
2023,
Номер
115, С. 154824 - 154824
Опубликована: Апрель 19, 2023
Every
day
the
skin
is
constantly
exposed
to
several
harmful
factors
that
induce
oxidative
stress.
When
cells
are
incapable
maintain
balance
between
antioxidant
defenses
and
reactive
oxygen
species,
no
longer
can
keep
its
integrity
homeostasis.
Chronic
inflammation,
premature
aging,
tissue
damage,
immunosuppression
possible
consequences
induced
by
sustained
exposure
environmental
endogenous
species.
Skin
immune
non-immune
together
with
microbiome
essential
efficiently
trigger
responses
For
this
reason,
an
ever-increasing
demand
for
novel
molecules
capable
of
modulating
functions
in
has
risen
level
their
development,
particularly
field
natural
product-derived
molecules.
In
review,
we
explore
different
classes
showed
evidence
modulate
responses,
as
well
target
receptors
signaling
pathways.
Moreover,
describe
role
polyphenols,
polysaccharides,
fatty
acids,
peptides,
probiotics
treatments
conditions,
including
wound
healing,
infection,
allergies,
aging.
Literature
was
searched,
analyzed,
collected
using
databases,
PubMed,
Science
Direct,
Google
Scholar.
The
search
terms
used
included
"Skin",
"wound
healing",
"natural
products",
"skin
microbiome",
"immunomodulation",
"anti-inflammatory",
"antioxidant",
"infection",
"UV
radiation",
"polyphenols",
"polysaccharides",
"fatty
acids",
"plant
oils",
"peptides",
"antimicrobial
peptides",
"probiotics",
"atopic
dermatitis",
"psoriasis",
"auto-immunity",
"dry
skin",
"aging",
etc.,
combinations
these
keywords.
Natural
products
offer
solutions
conditions.
Significant
anti-inflammatory
activities
were
reported,
followed
ability
skin.
Several
membrane-bound
recognize
diverse
types
natural-derived
molecules,
promoting
improve
Despite
increasing
progress
drug
discovery,
limiting
need
future
clarification.
Understanding
safety,
biological
activities,
precise
mechanisms
action
a
priority
characterization
active
compounds
responsible
that.
This
review
provides
directions
studies
development
new
important
pharmaceutical
cosmeceutical
value.
Abstract
Skin
aging
is
characterized
by
changes
in
its
structural,
cellular,
and
molecular
components
both
the
epidermis
dermis.
Dermal
distinguished
reduced
dermal
thickness,
increased
wrinkles,
a
sagging
appearance.
Due
to
intrinsic
or
extrinsic
factors,
accumulation
of
excessive
reactive
oxygen
species
(ROS)
triggers
series
events,
including
imbalanced
extracellular
matrix
(ECM)
homeostasis,
senescent
fibroblasts,
loss
cell
identity,
chronic
inflammation
mediated
senescence‐associated
secretory
phenotype
(SASP).
These
events
are
regulated
signaling
pathways,
such
as
nuclear
factor
erythroid
2‐related
2
(Nrf2),
mechanistic
target
rapamycin
(mTOR),
transforming
growth
beta
(TGF‐β),
insulin‐like
1
(IGF‐1).
Senescent
fibroblasts
can
induce
accelerate
age‐related
dysfunction
other
skin
cells
may
even
cause
systemic
inflammation.
In
this
review,
we
summarize
role
cutaneous
Moreover,
underlying
mechanisms
which
influence
also
discussed.
Pharmaceutics,
Год журнала:
2021,
Номер
13(12), С. 2012 - 2012
Опубликована: Ноя. 26, 2021
Many
dermatological
conditions,
such
as
eczema
and
psoriasis,
are
treated
with
topical
therapeutic
products.
Instead
of
applying
the
active
drug
directly
onto
skin,
it
is
combined
a
vehicle
to
aid
in
its
delivery
across
stratum
corneum
(SC)
into
deeper
regions
namely
epidermis
dermis.
Absorption
systemic
circulation
minimized.
Topical
vehicles
also
used
cosmetic
moisturizers
(often
termed
emollient
therapy)
ameliorate
dry
which
cornerstone
management
various
including
xerosis,
eczema,
aging.
The
most
common
include
ointments,
creams,
gels,
lotions,
among
others.
It
crucial
that
chosen
based
upon
size
properties
(wet/dry,
mucous/non-mucous,
healthy/diseased)
skin
be
order
optimize
application
contact
product
this
can
have
profound
impacts
on
potency,
efficacy,
patient
compliance.
This
review
examines
for
moisturizers,
their
formulation,
advantages
disadvantages,
effects
skin.
unique
rules
imposed
by
governing
regulatory
bodies
Australia
around
world,
terms
claims,
briefly
examined.
Ageing Research Reviews,
Год журнала:
2021,
Номер
71, С. 101456 - 101456
Опубликована: Сен. 3, 2021
Skin
is
the
largest
organ
of
body
with
important
protective
functions,
which
become
compromised
time
due
to
both
intrinsic
and
extrinsic
ageing
processes.
Cellular
senescence
primary
process
at
cell
level,
associated
loss
proliferative
capacity,
mitochondrial
dysfunction
significantly
altered
patterns
expression
secretion
bioactive
molecules.
Intervention
experiments
have
proven
as
a
relevant
cause
in
many
organs.
In
case
skin,
accumulation
all
major
compartments
well
documented
might
be
responsible
for
most,
if
not
all,
molecular
changes
observed
during
ageing.
Incorporation
senescent
cells
into
in-vitro
skin
models
(specifically
3D
full
thickness
models)
recapitulates
typically
However,
crucial
evidence
still
missing.
A
beneficial
effect
ablation
on
has
so
far
only
been
shown
following
rather
unspecific
interventions
or
transgenic
mouse
models.
We
conclude
that
cellular
highly
suggestive
but
yet
completely
conclusive.
Marine Drugs,
Год журнала:
2021,
Номер
19(3), С. 172 - 172
Опубликована: Март 22, 2021
The
skin
health
benefits
of
seaweeds
have
been
known
since
time
immemorial.
They
are
as
potential
renewable
sources
bioactive
metabolites
that
unique
structural
and
functional
features
compared
to
their
terrestrial
counterparts.
In
addition,
the
consciousness
green,
eco-friendly,
natural
skincare
cosmetics
products,
extracts
compounds
such
fucoidan,
laminarin,
carrageenan,
fucoxanthin,
mycosporine
like
amino
acids
(MAAs)
proven
useful
in
cosmetic
industries.
These
shown
anti-photoaging
properties.
Furthermore,
some
these
clinically
tested
currently
available
market.
this
contribution,
recent
studies
on
properties
derived
from
were
described
discussed.
ACS Nano,
Год журнала:
2022,
Номер
16(10), С. 15627 - 15652
Опубликована: Сен. 19, 2022
Biological
barriers
are
essential
physiological
protective
systems
and
obstacles
to
drug
delivery.
Nanoparticles
(NPs)
can
access
the
paracellular
route
of
biological
barriers,
either
causing
adverse
health
impacts
on
humans
or
producing
therapeutic
opportunities.
This
Review
introduces
structural
functional
influences
NPs
key
components
that
govern
route,
mainly
tight
junctions,
adherens
cytoskeletons.
Furthermore,
we
evaluate
their
interaction
mechanisms
address
influencing
factors
determine
ability
open
which
provides
a
better
knowledge
how
in
safer
more
controllable
way.
Finally,
summarize
limitations
research
models
methodologies
existing
field
provide
future
direction.
demonstrates
in-depth
causes
for
reversible
opening
destruction
integrity
generated
by
NPs;
importantly,
it
contributes
insights
into
design
NP-based
medications
boost
delivery
efficiency.
