Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Oncotarget, Год журнала: 2018, Номер 9(24), С. 17181 - 17198

Опубликована: Март 30, 2018

// Carolina Simioni 1 , Giorgio Zauli Alberto M. Martelli 2 Marco Vitale 3, 4 Gianni Sacchetti 5 Arianna Gonelli and Luca Neri Department of Morphology, Surgery Experimental Medicine, University Ferrara, Italy Biomedical Neuromotor Sciences, Bologna, 3 Medicine Surgery, Parma, CoreLab, Azienda Ospedaliero-Universitaria di Life Sciences Biotechnology, Pharmaceutical Biology Laboratory, Correspondence to: Neri, email: [email protected] Keywords: exercise training; nutraceuticals; flavonoids intake; aging; antioxidant supplementation Received: January 26, 2018      Accepted: March 08, Published: 30, 2018 ABSTRACT Physical is considered to be one the beneficial factors a proper lifestyle nowadays seen as an indispensable element for good health, able lower risk disorders cardiovascular, endocrine osteomuscular apparatus, immune system diseases onset potential neoplasms. A moderate programmed physical has often been reported therapeutic both in adulthood aging, since capable promote fitness. Regular alleviates negative effects caused by free radicals offers many health benefits, including reduced all-cause mortality, sarcopenia skeletal muscle, chronic disease, premature death elderly people. However, performance also known induce oxidative stress, inflammation, muscle fatigue. Many efforts have carried out identify micronutrients natural compounds, nutraceuticals, prevent or attenuate exercise-induced stress inflammation. The aim this review discuss benefits deriving from constant activity intake compounds protect body stress. attention will focused mainly on three antioxidants, which are quercetin, resveratrol curcumin. Their properties described, well their expected increase through years can get favorable activity.

Язык: Английский

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Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

Oxidative Medicine and Cellular Longevity, Год журнала: 2019, Номер 2019, С. 1 - 29

Опубликована: Март 12, 2019

Reactive oxygen species (ROS) are common by-products of normal aerobic cellular metabolism and play important physiological roles in intracellular cell signaling homeostasis. The human body is equipped with antioxidant systems to regulate the levels these free radicals maintain proper function. However, a condition known as oxidative stress (OS) occurs, when ROS overwhelm body’s ability readily detoxify them. Excessive amounts generated under OS conditions cause damage proteins, lipids, nucleic acids, severely compromising health contributing disease development, including cancer. Biomarkers can therefore be exploited tools assessment status humans. In present review, we discuss different approaches used for evaluation clinical samples. described methods limited their reflect on only partially, revealing need more integrative examining both pro- reactions higher sensitivity physiological/pathological alternations. We also provide an overview recent findings patients types Identification biomarkers samples cancer defining carcinogenesis hold great promise promoting development targeted therapeutic diagnostic strategies assessing status. considerable data variability across laboratories makes it difficult draw general conclusions significance biomarkers. To our knowledge, no adequate comparison has yet been performed between methodologies measure them, making conduct meta-analysis from groups. A critical adaptation proposed available literature should undertaken, enable investigators choose most suitable procedure each chosen biomarker.

Язык: Английский

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Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution

Antioxidants, Год журнала: 2024, Номер 13(3), С. 312 - 312

Опубликована: Март 1, 2024

Since the evolution of aerobic metabolism, reactive oxygen species (ROS) have represented significant challenges to diverse life forms. In recent decades, increasing knowledge has revealed a dual role for ROS in cell physiology, showing they serve as major source cellular damage while also functioning important signaling molecules various biological processes. Our understanding homeostasis and ROS-mediated pathways presumed that are ancient highly conserved mechanisms shared by most organisms. However, emerging evidence highlights complexity plasticity signaling, particularly animals evolved extreme environments. this review, we focus on generation, antioxidative systems main influenced ROS. addition, discuss ROS’s responsive transcription regulation how it may been shaped over course evolution.

Язык: Английский

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Advances in phytochemical delivery systems for improved anticancer activity

Biotechnology Advances, Год журнала: 2019, Номер 38, С. 107382 - 107382

Опубликована: Апрель 9, 2019

Язык: Английский

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Saponins in Cancer Treatment: Current Progress and Future Prospects

Pathophysiology, Год журнала: 2021, Номер 28(2), С. 250 - 272

Опубликована: Июнь 5, 2021

Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming nature. Different saponins have been characterized and purified gaining attention in cancer chemotherapy. possess high structural diversity, which linked to anticancer activities. Several studies reported role of mechanism actions, including cell-cycle arrest, antioxidant activity, cellular invasion inhibition, induction apoptosis autophagy. Despite extensive research significant effects saponins, there currently no known FDA-approved saponin-based drugs. This can be attributed a number limitations, toxicities drug-likeness properties. Recent explored options such as combination therapy drug delivery systems ensure increased efficacy decreased toxicity saponin. review discusses current knowledge on different their activity mechanisms action, well promising within last two decades recommendations for future studies.

Язык: Английский

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Review of cadmium toxicity effects on fish: Oxidative stress and immune responses

Environmental Research, Год журнала: 2023, Номер 236, С. 116600 - 116600

Опубликована: Июль 8, 2023

Язык: Английский

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Antimicrobial, Antibiofilm, and Anticancer Activities of Syzygium aromaticum Essential Oil Nanoemulsion

Molecules, Год журнала: 2023, Номер 28(15), С. 5812 - 5812

Опубликована: Авг. 1, 2023

In the current study, clove oil nanoemulsion (CL-nanoemulsion) and emulsion (CL-emulsion) were prepared through an ecofriendly method. The CL-nanoemulsion CL-emulsion characterized using dynamic light scattering (DLS) a transmission electron microscope (TEM), where results illustrated that droplets approximately 32.67 nm in size spherical shape, while 225.8 with shape. antibacterial activity of was carried out microbroth dilution Results revealed preferred had minimal MIC values between 0.31 5 mg/mL. antibiofilm efficacy against S. aureus significantly decreased development biofilm compared CL-emulsion. Furthermore, showed antifungal higher than Moreover, exhibited outstanding efficiency toward Candida albicans, Cryptococcus neoformans, Aspergillus brasiliensis, A. flavus, fumigatus MICs 12.5, 3.12, 0.78, 1.56, 1.56 mg/mL, respectively. Additionally, analyzed for its antineoplastic effects modified MTT assay evaluating apoptotic cytotoxic HepG2 MCF-7 cell lines. breast cancer cells lowest IC50 (3.4-fold) relative to Thus, induces apoptosis by inducing caspase-8 -9 suppressing VEGFR-2. conclusion, antibacterial, antifungal, as well anticancer properties, which can be used different biomedical applications after extensive studies vivo.

Язык: Английский

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Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Сен. 22, 2023

Cancer is a borderless global health challenge that continues to threaten human health. Studies have found oxidative stress (OS) often associated with the etiology of many diseases, especially aging process and cancer. Involved in OS reaction as key transcription factor, Nrf2 pivotal regulator cellular redox state detoxification. can prevent damage by regulating gene expression antioxidant response elements (ARE) promote process. generated an imbalance promotes accumulation mutations genome instability, thus establishment development different cancers. activation regulates plethora processes inducing proliferation, differentiation death, strongly OS-mediated What’s more, also involved anti-inflammatory effects metabolic disorders, neurodegenerative multidrug resistance. highly expressed multiple body parts digestive system, respiratory reproductive system nervous system. In oncology research, has emerged promising therapeutic target. Therefore, certain natural compounds drugs exert anti-cancer through signaling pathway, blocking pathway reduce some types tumor recurrence rates increase sensitivity chemotherapy. However, Nrf2’s dual role controversial impact cancer are inevitable consideration factors when treating this review, we summarized current biological characteristics its mechanism cells, discussed Keap1/Nrf2/ARE downstream genes, elaborated related pathways such AMPK/mTOR NF-κB. Besides, main target strategies using inhibitors or activators, well possible positive negative were reviewed. It be concluded serves important factor formation development, provides basis for targeted therapy

Язык: Английский

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Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

Molecules, Год журнала: 2024, Номер 29(6), С. 1373 - 1373

Опубликована: Март 20, 2024

Epigallocatechin gallate (EGCG) is a catechin, which type of flavonoid found in high concentrations green tea. EGCG has been studied extensively for its potential health benefits, particularly cancer. to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects numerous cancer cell lines animal models. demonstrated the ability interrupt various signaling pathways associated with cellular proliferation division different types. anticancer activity mediated by interfering hallmarks. This article summarize highlight on hallmarks focused impacts these cancer-related The studies discussed this review enrich understanding EGCG’s as therapeutic tool against cancer, offering substantial foundation scientists medical experts advance scientific clinical investigations regarding possibility treatment.

Язык: Английский

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Application of nano/microencapsulated phenolic compounds against cancer

Advances in Colloid and Interface Science, Год журнала: 2020, Номер 279, С. 102153 - 102153

Опубликована: Апрель 4, 2020

Язык: Английский

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