Physiological and Molecular Plant Pathology, Год журнала: 2025, Номер unknown, С. 102570 - 102570
Опубликована: Янв. 1, 2025
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(5), С. 504 - 504
Опубликована: Апрель 23, 2024
Despite the significant progress in fields of biology, physiology, molecular medicine, and pharmacology; designation properties nitrogen monoxide regulation life-supporting functions organism; numerous works devoted to this molecule, there are still many open questions field. It is widely accepted that nitric oxide (•NO) a unique molecule that, despite its extremely simple structure, has wide range body, including cardiovascular system, central nervous system (CNS), reproduction, endocrine respiration, digestion, etc. Here, we systematize •NO, contributing conditions physiological norms, as well various pathological processes, mechanisms cytoprotection cytodestruction. Current experimental clinical studies contradictory describing role •NO pathogenesis diseases CNS. We describe cytoprotective action associated with expression antiapoptotic chaperone proteins mitochondrial function. The most prominent cytodestruction—the initiation nitrosative oxidative stresses, production reactive oxygen species, participation apoptosis mitosis. formation endothelial dysfunction also considered. Moreover, focus on ways pharmacological modulation nitroxidergic allow for decrease cytodestructive increase ones.
Язык: Английский
Процитировано
20
Antioxidants, Год журнала: 2025, Номер 14(1), С. 72 - 72
Опубликована: Янв. 9, 2025
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes
Язык: Английский
Процитировано
5
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114046 - 114046
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Maejo 341 Sweet potato (MSP) is a new purple sweet variety cultivated in Northern Thailand, but its health benefits are unknown. This study aimed to investigate antioxidant, anti-inflammatory, and anti-osteoporotic activities, as well anthocyanin content. The peel flesh of MSP were extracted with ethanol water. Compared the extracts, extracts presented greater antioxidant capacity rich phenolics, flavonoids, anthocyanins, namely, cyanidin-3-O-glucoside, peonidin-3-O-glucoside, pelargonidin-3-O-glucoside, cyanidin, peonidin. suppressed lipopolysaccharide-induced inflammation by inhibiting secretion proinflammatory cytokines enzymes, including TNF-α, IL-1β, IL-6, COX-2, iNOS, reducing nitric oxide matrix metalloproteinase-9 secretion. inhibited RANKL-induced NF-κB MAPK pathways downregulated osteoclastogenic marker expression. Under LPS RANKL treatment, notably reduced reactive oxygen species production while increasing gene Furthermore, they increased osteoblast viability slightly raise alkaline phosphatase activity. These findings suggest that could be used functional food alleviate oxidative stress inflammation-related osteoporosis.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 31, 2025
Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, mitochondrial dysfunction. This study evaluated efficacy curcumin nanoparticles (CNPs) mitigating dysfunction senescence induced by rat brain tissues. Four groups male Wistar albino rats (n = 8 per group) were included: (Gr1) control group; (Gr2) CNPs group (healthy receiving oral administration at a dose 10 mg/kg/day, three times week for eight weeks); (Gr3) irradiated (rats exposed to single Gy head irradiation); (Gr4) + (irradiated treated with CNPs). The data obtained demonstrated that weeks attenuated oxidative stress γ-irradiated lowering brain's lipid peroxidation level [malondialdehyde (MDA)] enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), total capacity (TAC)] (P < 0.05). In addition, significantly increased function improving complex I, II, ATP production levels compared group. rats, also showed anti-neuroinflammatory reducing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), nuclear factor-kappa B (NF-ĸB) Moreover, administered β-galactosidase activity expression p53, p21, p16 genes 0.05) while concurrently inducing significant increase AMPK mRNA conclusion, ameliorated neurotoxicity hold promise novel agent delay via their combined antioxidant, anti-inflammatory, mitochondrial-enhancing properties.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12387 - 12387
Опубликована: Ноя. 18, 2024
Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve signaling agents that enhance cell proliferation, migration, resistance to drugs. However, at elevated levels, induce oxidative stress, causing damage biomolecules leading death. cells developed mechanisms manage activating pathways such NRF2, NF-κB, PI3K/Akt. This review explores relationship between cancer, focusing on death like apoptosis, ferroptosis, autophagy, highlighting potential strategies exploit target cells.
Язык: Английский
Процитировано
11
Antioxidants, Год журнала: 2024, Номер 13(10), С. 1158 - 1158
Опубликована: Сен. 25, 2024
Hydrogen sulfide (H
Язык: Английский
Процитировано
10
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6114 - 6114
Опубликована: Июнь 1, 2024
Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized transient effects due their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I III of the electron transport chain (ETC). Subsequent production triggers activation nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH 2), prolonging oxidative signal. This signal then engages kinase cascades such as mitogen-activated protein (MAPK) pathway increases activity REDOX-sensitive transcription factors nuclear factor-kappa B (NF-κB) activator protein-1 (AP-1). To limit overproduction prevent stress, factor erythroid 2-related (Nrf2) antioxidant proteins superoxide dismutases (SODs) finely regulate intensity capable terminating needed. Thus, signals, well-controlled critical for cellular communication.
Язык: Английский
Процитировано
8
Life Sciences, Год журнала: 2025, Номер unknown, С. 123393 - 123393
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 21, 2025
Oxidative stress (OS) refers to the disruption in balance between free radical generation and antioxidant defenses, leading potential tissue damage. Reactive oxygen species (ROS) can interact with biological components, triggering processes like protein oxidation, lipid peroxidation, or DNA damage, resulting of several volatile organic compounds (VOCs). Recently, VOCs provided new insight into cellular metabolism serve as biomarkers. The objective is investigate impact OS on cell by analyzing release alterations headspace differentiated 3T3-L1 adipocytes. An model lines was constructed using hydrogen peroxide (H2O2) treatment. effect analyzed detecting cells solid phase micro extraction (SPME) gas chromatography-mass spectrometry (GCMS). Our findings indicate that H2O2 concentrations exceeding 300 µM induce significant OS, adipocyte apoptosis, evidenced various assays. Of twenty identified, ten were upregulated cells. such diphenyl ether, 1,3,5-trioxane, 5-methyl tridecane, 2-ethyl-1-hexanol, 2,4-di-tert-butyl phenol emerged biomarkers for OS. This study demonstrates elevated alters VOC profiles adipocytes, providing insights effects adipose identifying
Язык: Английский
Процитировано
1